Neural Cell News Volume 15.33 | Aug 25 2021

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    2021-08-25 | NCN 15.33


    Neural Cell News by STEMCELL Technologies
    Vol. 15.33 – 25 August, 2021
    TOP STORY

    A Human Forebrain Organoid Model of Fragile X Syndrome Exhibits Altered Neurogenesis and Highlights New Treatment Strategies

    Researchers developed a fragile X syndrome human forebrain organoid model and observed that the loss of fragile X mental retardation protein led to dysregulated neurogenesis, neuronal maturation and neuronal excitability.
    [Nature Neuroscience]

    Abstract| Press Release

    Return to your lab safely and efficiently with these guides and resources so that you can focus more on moving your research goals forward.
    PUBLICATIONSRanked by the impact factor of the journal

    Identification of Neural Oscillations and Epileptiform Changes in Human Brain Organoids

    Scientists demonstrated highly abnormal and epileptiform-like activity in organoids derived from induced pluripotent stem cells from individuals with Rett syndrome.
    [Nature Neuroscience]

    Abstract| Press Release

    Ten-Eleven Translocation 1 Mediated-DNA Hydroxymethylation Is Required for Myelination and Remyelination in the Mouse Brain

    Researchers identified a genome-wide and locus-specific DNA hydroxymethylation landscape shift during differentiation of oligodendrocyte-progenitor cells.
    [Nature Communications]

    Full Article

    Treatment during a Developmental Window Prevents NF1-Associated Optic Pathway Gliomas by Targeting Erk-Dependent Migrating Glial Progenitors

    Scientists provided the proof-of-concept evidence for preventing pediatric low-grade gliomas before tumor-associated neurological damage entered an irreversible phase.
    [Developmental Cell]

    Full ArticleGraphical Abstract

    α-Synuclein-Induced Dysregulation of Neuronal Activity Contributes to Murine Dopamine Neuron Vulnerability

    Researchers employed molecular biology, electrophysiology, and live-cell imaging to investigate how excessive α-synuclein expression altered multiple characteristics of dopaminergic neuronal dynamics and dopamine transmission in cultured dopamine neurons conditionally expressing GCaMP6f.
    [npj Parkinson’s Disease]

    Full Article

    Generation of Multipotential NG2 Progenitors from Mouse Embryonic Stem Cell-Derived Neural Stem Cells

    Investigators developed a simple method to generate homogeneous immature oligodendrocyte lineage cells from mouse embryonic stem cells-derived neural stem cell.
    [Frontiers in Cell and Developmental Biology]

    Full Article

    Discovery of Novel MIF Inhibitors That Attenuate Microglial Inflammatory Activation by Structures-Based Virtual Screening and In Vitro Bioassays

    Twelve compounds with better bioactivity than the prototypical migration inhibitory factor-inhibitor ISO-1 were identified by an in vitro enzymatic activity assay.
    [Acta Pharmacologica Sinica]

    Abstract

    Benzimidazoles Induce Concurrent Apoptosis and Pyroptosis of Human Glioblastoma Cells via Arresting Cell Cycle

    By analyzing the hub genes of glioblastoma multiforme (GBM) via weighted gene co-expression network analysis of the cancer genome atlas dataset, and using the connectivity map platform for drug repurposing, scientists found that multiple azole compounds had potential anti-GBM activity.
    [Acta Pharmacologica Sinica]

    Abstract

    Sustained Postsynaptic Kainate Receptor Activation Downregulates AMPA Receptor Surface Expression and Induces Hippocampal LTD

    Researchers reported that sustained activation of GluK2 subunit-containing Kainate receptors leads to AMPA receptor endocytosis and induce long-term depression of AMPARs in hippocampal neurons.
    [iScience]

    AbstractGraphical Abstract

    Scientific resources to support your organoids research. Learn More!
    REVIEWS

    Microglia as Hackers of the Matrix: Sculpting Synapses and the Extracellular Space

    Scientists provide an overview of the microglial regulation of synapses, perisynaptic matrix, and perineuronal nets, propose candidate mechanisms by which these structures may be modified, and present the implications of such modifications in normal brain homeostasis and in disease.
    [Cellular & Molecular Immunology]

    Full Article

    The Prefrontal Cortex and (Uniquely) Human Cooperation: A Comparative Perspective

    The authors highlight a medial prefrontal network common to nonhuman primates and humans supporting a foundational process in cooperative decision-making: valuing outcomes for oneself and others.
    [Neuropsychopharmacology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Tabula Rasa and Hesperos Receive $1.9M National Institutes of Health Award for Research Focused on Preventable Drug-Induced Alzheimer’s Disease

    Tabula Rasa HealthCare, Inc.®, and Hesperos Inc.® in vitro systems, have been awarded $1.9 million in funding from the National Institutes of Health to investigate drug-induced dementia and develop new models that will drive Alzheimer’s research.
    [Tabula Rasa HealthCare, Inc.®]

    Press Release

    FEATURED EVENT

    Brain Cancer

    October 21 – 24, 2021
    Portland, Oregon, United States

    > See All Events

    JOB OPPORTUNITIES

    Associate Director – Data Science, Neurology

    Eisai Inc. – Woodcliff Lake, New Jersey, United States

    Postdoctoral Research Associate – In Vitro Electrophysiology

    University of Pittsburgh – Pittsburgh, Pennsylvania, United States

    Research Fellow – Neurology

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Researcher – Neuroimmunology of Brain Repair

    MSH Medical School Hamburg – Hamburg, Germany

    Postdoctoral Researcher – Electrophysiology of Neural Circuits with Gene Therapy

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    > See All Jobs

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