 | | Vol. 15.34 – 1 September, 2021 |
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| Scientists tested the hypothesis that the spatial propagation of microglial activation and tau accumulation colocalized in a Braak-like pattern in the living human brain.
[Nature Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators generated a induced pluripotent stem cell Alzheimer’s disease model using human derived cells, which showed signs of Aβ plaques, dystrophic neurites around plaques, synapse loss, dendrite retraction, axon fragmentation, phospho-Tau induction, and neuronal cell death in one model.
[Nature Communications] |
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| Researchers generated cortical organoids from skin fibroblasts of patients with 16p11.2 copy number varient to investigate impacted neurodevelopmental processes and showed that organoid size recapitulated macrocephaly and microcephaly phenotypes observed in the patients with 16p11.2 deletions and duplications.
[Molecular Psychiatry] |
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| The exact role of SOX10 in human neural crest development and the underlying molecular mechanisms of SOX10-related human diseases remain poorly understood due to the lack of appropriate human model systems. Researchers successfully generated SOX10-knockout human induced pluripotent stem cells by the CRISPR-Cas9 gene editing tool.
[Cell Death & Disease] |
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| Genetic and pharmacological inhibition of dihydroorotate dehydrogenase suppressed the proliferation and tumorigenicity of MYCN-amplified neuroblastoma cell lines.
[Cell Death & Disease] |
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| The experiments used a novel flow cytometry assay to quantify depolarization of synaptosomes by KCl after loading with FM2–10, which induced a fluorescence reduction associated with synaptic vesicle release; the degree of reduction in cryopreserved human samples equaled that seen in fresh mouse synaptosomes.
[Laboratory Investigation] |
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| Monospecific antibodies were generated that recognized the neo-epitope predicted to be generated by cleavage after Asp121. These antibodies were used to localize cleavage events at Asp121 in post-mortem CADASIL and control brain tissue and to investigate factors that regulate cleavage at Asp121.
[Scientific Reports] |
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| Researchers showed that astrocyte elevated gene-1 (AEG-1) was overexpressed in glioma tissues and associated with a worse subtype and a poor prognosis.
[Scientific Reports] |
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| Scientists demonstrated that genomic integration of expression cassettes for a pyrrolysyl-tRNA synthetase, pyrrolysyl-tRNA and the target protein of interest enables site-specific incorporation of a non-canonical amino acid in response to amber stop codons.
[Chembiochem] |
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| Scientists discuss recent findings regarding how neural crest cells may have evolved during the course of deuterostome evolution.
[Nature Reviews Neuroscience] |
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| Teva Pharmaceuticals, and MedinCell announced that the New Drug Application for TV-46000/mdc-IRM for the treatment of schizophrenia has been accepted by the US FDA.
[Teva Pharmaceuticals, Ltd. (BusinessWire, Inc.)] |
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| November 29 – December 1, 2021
Barcelona, Spain |
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| University of Maryland, College Park – College Park, Maryland, United States |
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| Eisai Inc. – Woodcliff Lake, New Jersey, United States |
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| University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| MSH Medical School Hamburg – Hamburg, Germany |
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