 | | Vol. 16.11 – 23 March, 2022 |
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| Researchers analyzed bulk exome and single-cell genome and transcriptome profiles of 12 IDH wild-type GBMs, including two recurrent tumors, and of patient-derived explants and gliomasphere lines derived from these tumors.
[Cancer Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors reported that FOXG1 was expressed in the main adult neurogenic niches in mice, i.e. the hippocampal dentate gyrus and the subependymal zone/olfactory bulb system, where neurogenesis of glutamatergic and GABAergic neurons persisted into adulthood.
[Molecular Psychiatry] |
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| Scientists established DamID- and HiC-based methodologies to generate accurate genome-wide maps of nucleolar associated domains in ESCs and neural progenitor cells, revealing layers of genome compartmentalization with distinct, repressive chromatin states.
[Nature Communications] |
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| Depletion of glycosyltransferase 8 domain containing 1 (GLT8D1) inhibited self-renewal of glioma stem cells in vitro and repressed tumor growth in glioma mouse models.
[Cell Death & Differentiation] |
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| The authors suggested that hepatocyte nuclear factor 4 alpha antisense RNA 1 (HNF4A-AS1)-encoded small 51-amino acid peptide promoted self-renewal and aggressive features of neuroblastoma stem cells by eEF1A1-repressed SMAD family member 4 (SMAD4) transactivation.
[Oncogene] |
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| RNA was isolated from the retinas of wild-type mice and mice deficient in Jun, Ddit3, and both Jun and Ddit3 three days after mechanical optic nerve crush injury.
[Cell Death & Disease] |
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| Investigators showed that adipose stem cell-derived extracellular vesicles exerted antiapoptotic effects by inhibiting endoplasmic reticulum (ER) stress in corticosterone-induced cortical neurons.
[Stem Cell Research & Therapy] |
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| Cultured Fbxo41 null mutant neurons had normal morphology and showed no signs of degeneration. Single cell electrophysiology showed a lower synaptic vesicle release probability in excitatory neurons.
[iScience] |
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| By promoting matrix-supported active cell reaggregation, researchers engineered multiregional cerebral tissues with intact 3D neuronal networks and functional interconnectivity characteristic of brain networks.
[Communications Biology] |
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| Considering sphingolipids as a trigger mechanism for learning and memory under physiological and pathological conditions, a principally new class of lipid-based preventive and therapeutic approaches to target cognitive impairments and dementias is emerging.
[Progress in Lipid Research] |
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| The authors summarize important discussion points with emphasis on the research areas that are most innovative and promising in the treatment of neurodegeneration yet require further development.
[Molecular Neurodegeneration] |
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| On March 15, 2022, President Biden signed into law the $1.5 trillion fiscal year 2022 omnibus federal spending bill which includes a $10 million increase in Down syndrome research funding at the National Institutes of Health (NIH) above last fiscal year’s funding level.
[Global Down Syndrome Foundation] |
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| April 7 – April 9
Rome, Italy & Virtual |
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| | McGill University – Montreal, Quebec, Canada |
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| | Flanders Institute for Biotechnology – Antwerp, Belgium |
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| | University of Bern – Bern, Switzerland |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | Baylor College of Medicine – Houston, TX, United States |
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