Neural Cell News Volume 16.17 | May 4 2022

May 4, 2022

2022-05-05 | NCN 16.17

Neural Cell News by STEMCELL Technologies

Vol. 16.17 – 4 May, 2022

TOP STORY

Modulation of the Crosstalk between Schwann Cells and Macrophages for Nerve Regeneration: A Therapeutic Strategy Based on Multifunctional Tetrahedral Framework Nucleic Acids System

Investigators adopted an innovative approach to establish a multifunctional tetrahedral framework nucleic acids system, denoted MiDs, which could integrate the powerful programmability, permeability, and structural stability of tFNAs.
[Advanced Materials]

Abstract

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PUBLICATIONSRanked by the impact factor of the journal

Axonal Transport of Late Endosomes and Amphisomes Is Selectively Modulated by Local Ca²⁺ Efflux and Disrupted by PSEN1 Loss of Function

Dysfunction and mistrafficking of organelles in autophagy- and endosomal-lysosomal pathways are implicated in neurodegenerative diseases. Scientists revealed selective vulnerability of maturing degradative organelles to disease-relevant local calcium dysregulation.
[Science Advances]

Full Article

Transcription Factor 4 Loss-of-Function Is Associated with Deficits in Progenitor Proliferation and Cortical Neuron Content

The authors showed that neural progenitors bearing mutations in transcription factor 4 had reduced proliferation and impaired capacity to differentiate into neurons.
[Nature Communications]

Full Article Press Release

Versican Promotes T Helper 17 Cytotoxic Inflammation and Impedes Oligodendrocyte Precursor Cell Remyelination

Researchers correlated high versican-V1 expression in MS lesions with deficient premyelinating oligodendrocytes and highlighted its selective upregulation amongst chondroitin sulfate proteoglycans members in experimental autoimmune encephalomyelitis lesions modeling MS.
[Nature Communications]

Full Article

Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma

In patient-derived isocitrate dehydrogenase wildtype glioblastoma multiforme tumors in vitro and in vivo, co-treatment of branched-chain amino acid transaminase 1 (BCAT1) inhibitor gabapentin and AKG resulted in synthetic lethality.
[Cancer Research]

Abstract

Loss-of-Function Variants in the Schizophrenia Risk Gene SETD1A Alter Neuronal Network Activity in Human Neurons through the cAMP/PKA Pathway

Using CRISPR-Cas9, the authors generated excitatory/inhibitory neuronal networks from human induced pluripotent stem cells with a SETD1A heterozygous loss-of-function mutation.
[Cell Reports]

Full Article Graphical Abstract

The Dual Role of Glioma Exosomal microRNAs: Glioma Eliminates Tumor Suppressor miR-1298-5p via Exosomes to Promote Immunosuppressive Effects of MDSCs

In order to study the biological function and characterization of exosomal miRNAs, researchers performed whole-transcriptome sequencing in 59 patients’ whole-course cerebrospinal fluid small extracellular vesicles and matched glioma tissue samples.
[Cell Death & Disease]

Full Article

Rho Family GTPase 1 (RND1), a Novel Regulator of p53, Enhances Ferroptosis in Glioblastoma

Scientists found that RND1, a novel controller of p53 protein and a positive regulator of p53 signaling pathway, enhanced the ferroptosis in glioblastoma.
[Cell & Bioscience]

Full Article

rhEPO Upregulates the PPARγ Pathway in Long-term Cultured Primary Nerve Cells via PI3K/Akt to Delay Cell Senescence

Researchers explored the relationship between recombinant human erythropoietin (rhEPO) and the proliferator-activated receptors γ (PPARγ) pathway at the cellular level. Primary nerve cells were used to simulate the natural aging process of nerve cells.
[Journal of Molecular Neuroscience]

Abstract

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REVIEWS

Bioactive Human Alzheimer Brain Soluble Aβ: Pathophysiology and Therapeutic Opportunities

Investigators review updated knowledge on the extraction and characterization of bioactive human Alzheimer’s disease brain oligomers of amyloid-β protein (Aβ) and the mechanisms by which they cause hippocampal synaptic dysfunction.
[Molecular Psychiatry]

Abstract

Neuroplasticity Related to Chronic Pain and Its Modulation by Microglia

Scientists highlight the mechanisms underlying neuroplasticity that occur in the somatosensory circuit of the spinal dorsal horn, thalamus, and cortex associated with chronic pain following injury to the peripheral nervous system or central nervous system.
[Inflammation and Regeneration]

Full Article

Microtubule Dynamics Following Central and Peripheral Nervous System Axotomy

The authors discuss the microtubule (MT) dynamics post axotomy in the central nervous system and peripheral nervous system, and factors that can directly influence MT stability in various diseases.
[ACS Chemical Neuroscience]

Abstract Graphical Abstract

INDUSTRY AND POLICY NEWS

Denali Therapeutics Announces Achievement of RIPK1 Milestone for Phase II Clinical Trial Initiation in ALS by Sanofi

Denali Therapeutics, Inc. announced that its partner Sanofi has commenced dosing in a Phase II study, named HIMALAYA, of SAR443820 in individuals with ALS.
[Denali Therapeutics, Inc.]

Press Release

Vaxxinity Receives FDA Fast Track Designation for UB-311 for Treatment of Alzheimer’s Disease

Vaxxinity, Inc. announced that UB-311, an anti-amyloid beta immunotherapeutic vaccine, has been granted Fast Track designation by the US FDA for the treatment of Alzheimer’s disease.
[Vaxxinity, Inc.]

Press Release

FEATURED EVENT

Neural Cell News Volume 16.17 | May 4 2022

Modulation of the Crosstalk between Schwann Cells and Macrophages for Nerve Regeneration: A Therapeutic Strategy Based on Multifunctional Tetrahedral Framework Nucleic Acids System

Axonal Transport of Late Endosomes and Amphisomes Is Selectively Modulated by Local Ca²⁺ Efflux and Disrupted by PSEN1 Loss of Function

Transcription Factor 4 Loss-of-Function Is Associated with Deficits in Progenitor Proliferation and Cortical Neuron Content

Versican Promotes T Helper 17 Cytotoxic Inflammation and Impedes Oligodendrocyte Precursor Cell Remyelination

Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma

Loss-of-Function Variants in the Schizophrenia Risk Gene SETD1A Alter Neuronal Network Activity in Human Neurons through the cAMP/PKA Pathway

The Dual Role of Glioma Exosomal microRNAs: Glioma Eliminates Tumor Suppressor miR-1298-5p via Exosomes to Promote Immunosuppressive Effects of MDSCs

Rho Family GTPase 1 (RND1), a Novel Regulator of p53, Enhances Ferroptosis in Glioblastoma

rhEPO Upregulates the PPARγ Pathway in Long-term Cultured Primary Nerve Cells via PI3K/Akt to Delay Cell Senescence

Bioactive Human Alzheimer Brain Soluble Aβ: Pathophysiology and Therapeutic Opportunities

Neuroplasticity Related to Chronic Pain and Its Modulation by Microglia

Microtubule Dynamics Following Central and Peripheral Nervous System Axotomy

Denali Therapeutics Announces Achievement of RIPK1 Milestone for Phase II Clinical Trial Initiation in ALS by Sanofi

Vaxxinity Receives FDA Fast Track Designation for UB-311 for Treatment of Alzheimer’s Disease

European Association for Cancer Research (EACR) 2022: Innovative Cancer Science

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