Neural Cell News Volume 16.17 | May 4 2022

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    2022-05-05 | NCN 16.17


    Neural Cell News by STEMCELL Technologies
    Vol. 16.17 – 4 May, 2022
    TOP STORY

    Modulation of the Crosstalk between Schwann Cells and Macrophages for Nerve Regeneration: A Therapeutic Strategy Based on Multifunctional Tetrahedral Framework Nucleic Acids System
    Investigators adopted an innovative approach to establish a multifunctional tetrahedral framework nucleic acids system, denoted MiDs, which could integrate the powerful programmability, permeability, and structural stability of tFNAs.
    [Advanced Materials]
    Abstract
    Explore neural organoid technologies with this free wallchart from STEMCELL and Nature Neuroscience
    PUBLICATIONSRanked by the impact factor of the journal

    Axonal Transport of Late Endosomes and Amphisomes Is Selectively Modulated by Local Ca2+ Efflux and Disrupted by PSEN1 Loss of Function
    Dysfunction and mistrafficking of organelles in autophagy- and endosomal-lysosomal pathways are implicated in neurodegenerative diseases. Scientists revealed selective vulnerability of maturing degradative organelles to disease-relevant local calcium dysregulation.
    [Science Advances]
    Full Article

    Transcription Factor 4 Loss-of-Function Is Associated with Deficits in Progenitor Proliferation and Cortical Neuron Content
    The authors showed that neural progenitors bearing mutations in transcription factor 4 had reduced proliferation and impaired capacity to differentiate into neurons.
    [Nature Communications]
    Full ArticlePress Release

    Versican Promotes T Helper 17 Cytotoxic Inflammation and Impedes Oligodendrocyte Precursor Cell Remyelination
    Researchers correlated high versican-V1 expression in MS lesions with deficient premyelinating oligodendrocytes and highlighted its selective upregulation amongst chondroitin sulfate proteoglycans members in experimental autoimmune encephalomyelitis lesions modeling MS.
    [Nature Communications]
    Full Article

    Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma
    In patient-derived isocitrate dehydrogenase wildtype glioblastoma multiforme tumors in vitro and in vivo, co-treatment of branched-chain amino acid transaminase 1 (BCAT1) inhibitor gabapentin and AKG resulted in synthetic lethality.
    [Cancer Research]
    Abstract

    Loss-of-Function Variants in the Schizophrenia Risk Gene SETD1A Alter Neuronal Network Activity in Human Neurons through the cAMP/PKA Pathway
    Using CRISPR-Cas9, the authors generated excitatory/inhibitory neuronal networks from human induced pluripotent stem cells with a SETD1A heterozygous loss-of-function mutation.
    [Cell Reports]
    Full ArticleGraphical Abstract

    The Dual Role of Glioma Exosomal microRNAs: Glioma Eliminates Tumor Suppressor miR-1298-5p via Exosomes to Promote Immunosuppressive Effects of MDSCs
    In order to study the biological function and characterization of exosomal miRNAs, researchers performed whole-transcriptome sequencing in 59 patients’ whole-course cerebrospinal fluid small extracellular vesicles and matched glioma tissue samples.
    [Cell Death & Disease]
    Full Article

    Rho Family GTPase 1 (RND1), a Novel Regulator of p53, Enhances Ferroptosis in Glioblastoma
    Scientists found that RND1, a novel controller of p53 protein and a positive regulator of p53 signaling pathway, enhanced the ferroptosis in glioblastoma.
    [Cell & Bioscience]
    Full Article

    rhEPO Upregulates the PPARγ Pathway in Long-term Cultured Primary Nerve Cells via PI3K/Akt to Delay Cell Senescence
    Researchers explored the relationship between recombinant human erythropoietin (rhEPO) and the proliferator-activated receptors γ (PPARγ) pathway at the cellular level. Primary nerve cells were used to simulate the natural aging process of nerve cells.
    [Journal of Molecular Neuroscience]
    Abstract
    Return to your lab safely and efficiently with these guides and resources so that you can focus more on moving your research goals forward.
    REVIEWS

    Bioactive Human Alzheimer Brain Soluble Aβ: Pathophysiology and Therapeutic Opportunities
    Investigators review updated knowledge on the extraction and characterization of bioactive human Alzheimer’s disease brain oligomers of amyloid-β protein (Aβ) and the mechanisms by which they cause hippocampal synaptic dysfunction.
    [Molecular Psychiatry]
    Abstract

    Neuroplasticity Related to Chronic Pain and Its Modulation by Microglia
    Scientists highlight the mechanisms underlying neuroplasticity that occur in the somatosensory circuit of the spinal dorsal horn, thalamus, and cortex associated with chronic pain following injury to the peripheral nervous system or central nervous system.
    [Inflammation and Regeneration]
    Full Article

    Microtubule Dynamics Following Central and Peripheral Nervous System Axotomy
    The authors discuss the microtubule (MT) dynamics post axotomy in the central nervous system and peripheral nervous system, and factors that can directly influence MT stability in various diseases.
    [ACS Chemical Neuroscience]
    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Denali Therapeutics Announces Achievement of RIPK1 Milestone for Phase II Clinical Trial Initiation in ALS by Sanofi
    Denali Therapeutics, Inc. announced that its partner Sanofi has commenced dosing in a Phase II study, named HIMALAYA, of SAR443820 in individuals with ALS.
    [Denali Therapeutics, Inc.]
    Press Release

    Vaxxinity Receives FDA Fast Track Designation for UB-311 for Treatment of Alzheimer’s Disease
    Vaxxinity, Inc. announced that UB-311, an anti-amyloid beta immunotherapeutic vaccine, has been granted Fast Track designation by the US FDA for the treatment of Alzheimer’s disease.
    [Vaxxinity, Inc.]
    Press Release
    FEATURED EVENT

    European Association for Cancer Research (EACR) 2022: Innovative Cancer Science
    June 20 – 23, 2022
    Sevilla, Spain

    > See All Events
    JOB OPPORTUNITIES

    Postdoctoral Position – Parental Diet and Neuronal Development
    Helmholtz Munich – Neuherberg, Germany

    PhD Position – Neuroepithelial Circuits
    Philipps-University Marburg – Marburg, Germany

    Postdoctoral Research Assistant – Protein Phosphorylation and Ubiquitylation
    University of Dundee – Dundee, Scotland, United Kingdom

    Faculty Positions – Neuroscience
    The Hong Kong University of Science and Technology – Guangzhou, China

    Postdoctoral Fellow – Leptin Signaling Lab
    Pennington Biomedical Research Center – Baton Rouge, Louisiana, United States

    > See All Jobs

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