 | | Vol. 16.31 – 10 August, 2022 |
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| Scientists employed CRISPR-edited induced pluripotent stem cells to dissect the impact of apolipoprotein E4 (APOE4) in neuron-microglia communication.
[Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors demonstrated that high doses of nicotine, which induced aversion-related behavior in mice, caused biphasic inhibitory and excitatory responses in VTA dopamine neurons that could be dissociated by distinct projections to lateral and medial nucleus accumben subregions, respectively.
[Neuron] |
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| Whole neuron reconstructions from mice infected with parasites that triggered neuron green fluorescent protein expression only after full invasion revealed that ~50% of these T. gondii-invaded neurons no longer harbored parasites.
[Nature Communications] |
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| To tie OTU deubiquitinase 7A (OTUD7A) loss-of-function (LoF) with any schizophrenia-relevant cellular phenotypes, researchers modeled the OTUD7A LoF mutation, rs757148409, in human induced pluripotent stem cell (hiPSC)-derived induced excitatory neurons by CRISPR-Cas9 engineering.
[American Journal of Human Genetics] |
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| Scientists found that during a critical developmental window for establishing postmitotic neuronal identity, newly generated cortical excitatory neurons substantially accumulate the histone H3 variant H3.3.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators induced the differentiation of cortical neurons from dual-reporter human induced pluripotent stem cells, successfully visualizing cell-fate conversion in 2D culture and 3D organoids.
[Stem Cell Reports] |
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| The authors evaluated and compared the therapeutic effects of neural stem cell (NSC) and glibenclamide (GBC) therapies post-cardiac arrest. In in vitro studies, BV2 cells underwent oxygen–glucose deprivation for three hours and were then treated with GBC or co-cultured with human NSCs.
[Translational Stroke Research] |
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| Scientists found that treatment with a standard dose of propofol promoted glioma growth in nude mice compared with control or low-dose propofol. Propofol-treated glioma stem cells also led to larger tumor growth in nude mice than did vector-treated tumors.
[Stem Cell Research & Therapy] |
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| Researchers found that R-loops in neural stem/progenitor cells undergoing mild replication stress were present primarily in early-replicating, transcribed regions and in genes with promoter GC skewed that were associated with cell lineage-specific processes.
[Scientific Reports] |
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| With high-density CMOS microelectrode arrays and shank electrodes, we captured spontaneous extracellular activity from brain organoids derived from human induced pluripotent stem cells.
[Nature Commmunications] |
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| MiR‑124‑3p was selected according to previous studies by the authors, and the effects of the delivery of miR‑124‑3p to glioma cells by neural stem cell‑exosomes in vitro and in vivo were evaluated.
[International Journal of Oncology] |
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| Scientists review recent advances made in understanding the multifaceted roles that CD33 plays in microglia with emphasis on two human-specific CD33 isoforms that differentially correlate with Alzheimer’s disease susceptibility.
[Molecular Aspects of Medicine] |
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| Cerevance announced a multi-year strategic research collaboration with Merck, known as MSD outside the United States and Canada, to identify novel targets for Alzheimer’s disease utilizing Cerevance’s proprietary Nuclear Enriched Transcript Sort sequencing technology platform.
[Cerevance] |
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| Through a five-year, $4 million R01 grant from the National Institutes of Health, Karin Schon plans to examine how cardiorespiratory fitness and chronic psychosocial stress interact the brain in Black emerging adults who are exposed to daily social stress, examined through the lens of racism-rated chronic stress.
[Boston University] |
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| September 12 – 14, 2022
Liverpool, England, United Kingdom |
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| | Dalla Lana School of Public Health – Toronto, Ontario, Canada |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Murdoch Children’s Research Institute – Location |
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| | Karolinska Institutet – Solna, Sweden |
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| | Jülich Research Centre – Jülich, Germany |
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