 | | Vol. 16.33 – 24 August, 2022 |
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| Investigators characterized the consequences of manipulating target gene expression in human induced pluripotent stem cell–derived neurons and other cell models.
[Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Utilizing directly converted induced neurons (iNs) from Alzheimer’s disease (AD)-patient-derived fibroblasts, the authors identified a metabolic switch to aerobic glycolysis in AD iNs.
[Cell Metabolism] |
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| Scientists generated a new mouse model to specifically immunoisolate neuronal lysosomes, and established a long-term culture model where α-Synuclein aggregates were produced within neurons without the addition of exogenous fibrils.
[Nature Communications] |
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| Researchers reported that DNGR-1 lineage tracing in mice identified an ependymal cell subset, wherein resided latent regenerative potential.
[Developmental Cell] |
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| Investigators reported that exosomes released from glioma stem-like cells contained a significant increasing level of miR-155-5p and could be horizontally transferred to surrounding glioma cells.
[Cell Death & Disease] |
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| Researchers reported that USP10, one of the important deubiquitinase, was involved in Tau aggregation.
[Cell Death & Disease] |
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| The authors reported that reductions in Fragile X Messenger Ribonucleoprotein (FMRP) correlated with a diminished tumor growth and proliferation of human glioblastoma stem-like cells (GSCs) in vitro in a cell culture model and in vivo in mouse brain GSC xenografts.
[Cell Death & Disease] |
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| Scientists found that in human cerebral organoids carrying the V337M and R406W tau mutations, the cholesterol biosynthesis pathway in astrocytes was the top upregulated gene set compared with isogenic controls by single-cell RNA sequencing.
[Stem Cell Reports] |
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| The authors provide evidence that supports the notion that arrested neural-crest-derived progenitor cells give rise to neuroblastoma and discuss how this concept could be exploited for clinical management of the disease.
[Neuron] |
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| Scientists introduce the role of Voltage-gated calcium channels in Parkinson’s Disease and discuss some novel aspects of channel regulation and its impact on the molecular pathophysiology of the disease.
[International Journal of Neuroscience] |
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| Researchers at the University of California San Diego have received a $1.3 million grant from the W. M. Keck Foundation for a project that could help scientists better understand the role misfolded tau proteins play in causing neurodegenerative diseases like dementia, which may lead to more effective drug therapies.
[UC San Diego] |
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| October 7 – 10, 2022
Beaver Run Resort, Colorado, United States |
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| | Yale University – New Haven, Connecticut, United States |
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| | Novartis – Cambridge, Massachusetts, United States |
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| | University of Calgary – Calgary, Alberta, Canada |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Jülich Research Centre – Jülich, Germany |
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