Neural Cell News Volume 16.35 | Sep 7 2022

    By
    lbeveridge
    -
    0
    29








    2022-09-06 | NCN 16.35


    Neural Cell News by STEMCELL Technologies
    Vol. 16.35 – 7 September, 2022
    TOP STORY

    Molecular Diversity and Evolution of Neuron Types in the Amniote Brain

    Investigators profiled 285,483 single-cell transcriptomes from the brain of Pogona and identified and annotated 233 distinct types of neurons.
    [Science]

    AbstractGraphical AbstractPress Release
    Register now for the VIB Neurotechnologies conference.
    PUBLICATIONSRanked by the impact factor of the journal

    Single-Cell Analyses of Axolotl Telencephalon Organization, Neurogenesis, and Regeneration

    The authors applied single-nucleus genomic profiling to an axolotl telencephalon in steady state and during regeneration to investigate its cell-type diversity and molecular dynamics of homeostatic neurogenesis.
    [Science]

    AbstractGraphical Abstract

    Wireless Charging-Mediated Angiogenesis and Nerve Repair by Adaptable Microporous Hydrogels From Conductive Building Blocks

    Scientists presented an adaptable conductive microporous hydrogel consisting of gold nanoyarn balls-coated injectable building blocks possessing interconnected pores to improve angiogenesis and recovery of brain function in traumatic brain injury.
    [Nature Communications]

    Full Article

    Amelioration of Pathologic α-Synuclein-Induced Parkinson’s Disease by Irisin

    Researchers showed that irisin prevented pathologic α-synuclein-induced neurodegeneration in the α-syn preformed fibril mouse model of sporadic Parkinson’s disease.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Miat and Interacting Protein Metadherin Maintain a Stem-Like Niche to Promote Medulloblastoma Tumorigenesis and Treatment Resistance

    Investigators identified Miat as an lncRNA enriched in the sonic hedgehog group of medulloblastoma that was required for maintenance of a treatment-resistant stem-like phenotype in the disease.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Identifying the Role of Co-Aggregation of Alzheimer’s Amyloid-β With Amorphous Protein Aggregates of Non-Amyloid Proteins

    Scientists examined the interactions between the amorphously aggregated non-chaperone proteins and Alzheimer’s amyloid-β peptides.
    [Cell Reports Physical Science]

    Full ArticleGraphical Abstract

    RBM45 Is an m6MA-Binding Protein That Affects Neuronal Differentiation and the Splicing of a Subset of mRNAs

    The authors found that RBM45 bound to thousands of cellular RNAs, predominantly within intronic regions. RBM45 was necessary for neuroblastoma cell differentiation and its depletion impacted the expression of genes involved in several neurodevelopmental signaling pathways.
    [Cell Reports]

    Full ArticleGraphical Abstract

    IRES-Mediated Wnt2 Translation in Apoptotic Neurons Triggers Astrocyte Dedifferentiation

    Researchers reported that ischemia induces rapid up-regulation of Wnt2 protein in apoptotic neurons and activation of canonical Wnt signaling in reactive astrocytes in mice, primates, and humana.
    [NPJ Regenerative Medicine]

    Full Article

    Aβ-Induced Mitochondrial Dysfunction in Neural Progenitors Controls KDM5A To Influence Neuronal Differentiation

    Scientists showed that mitochondrial dysfunction induced by amyloid-beta in neural progenitors inhibited neuronal differentiation but had no effect on the neural progenitor stage.
    [Experimental & Molecular Medicine]

    Full Article

    Mechanosensitive Expression of the Mesenchymal Subtype Marker Connective Tissue Growth Factor in Glioblastoma

    Investigators tested the hypothesis that stiffer microenvironments — such as those found in different brain anatomical structures and induced following treatment — contributed to the expression of markers characterizing the mesenchymal subtype.
    [Scientific Reports]

    Full Article
    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    REVIEWS

    The Multiple Functions of PrPC in Physiological, Cancer, and Neurodegenerative Contexts

    Cellular prion protein (PrPC) has been related to several types of tumors, modulating cancer stem cells, enhancing malignant properties, and inducing drug resistance.
    [Journal of Molecular Medicine]

    Abstract
    INDUSTRY AND POLICY NEWS

    Karl Deisseroth to Share Horwitz Prize for Pioneering Contributions to Optogenetics

    Dr. Karl Deisseroth, the Stanford Medicine D.H. Chen Professor, has been named a recipient of the 2022 Louisa Gross Horwitz Prize for his foundational contributions to the advancement of optogenetics, a technology that has transformed neuroscientific research.
    [Standford Medicine]

    Press Release
    FEATURED EVENT

    Neuroscience 2022

    November 12 – 16, 2022
    San Diego, California, United States

    > See All Events

    JOB OPPORTUNITIES

    PhD Fellowship – Gene Therapy

    Max Delbrück Center for Molecular Medicine – Berlin, Germany

    Postdoctoral/Research Scientist – CRISPR/Cas Genome Editors

    Lewis Katz School of Medicine, Temple University – Philadelphia, Pennsylvania, United States

    Research Technologist – Tissue and Cell Biology

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Associate Professor – Solid Cancer Tumor Development

    Michigan State University – East Lansing, Michigan, United States

    Faculty Position – Translational Neuroscience

    Boston Children’s Hospital – Boston, Massachusetts, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Neural Cell News Twitter