 | | Vol. 16.36 – 14 September, 2022 |
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| Knockout in fetal human neocortical tissue, and genome-edited cerebral organoids, scientists found that the modern human variant, human Transketolase-like 1 (TKTL1), but not the Neanderthal variant, increases the abundance of basal radial glia but not that of intermediate progenitors
[Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers investigated whether inhibition of FKBP51 with SAFit2, a novel selective inhibitor, promotes hippocampal neuron outgrowth and neurogenesis in vitro and stress resilience in vivo, in a mouse model of chronic psychosocial stress.
[Molecular Psychiatry] |
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| ARHGAP11B expression in chimpanzee cerebral organoids doubled basal progenitor levels, the class of cortical progenitors with a key role in neocortex expansion.
[EMBO Reports] |
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| Investigators compared the cell composition of cerebral organoids (COs) at different culture time and explored the cell types, cell ratios, and volume size of COs at 85 days.
[Acta Pharmacologica Sinica] |
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| Protocells provided the ability to transport and release cytotoxic drugs while polymeric nanocapsules offered the capacity to transport enzymes to the tumoral tissues, preserving their catalytic activity.
[Advanced Materials Interfaces] |
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| Investigators erected the co-culture system of glioblastoma cells and microglia. After radiation, they analyzed the immunophenotype of microglia and the proliferation of radiated glioblastoma cells.
[Journal of Translational Medicine] |
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| Proliferation and differentiation of Piezo1 knockout mouse neural stem cells isolated from E10.5 embryos were reduced in vitro compared to littermate wildtype neural stem cells.
[Journal of General Physiology] |
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| Researchers identified 122 differentially expressed genes of Alzheimer’s disease and glioblastoma multiforme. Four significant gene modules were identified through protein–protein interaction and module construction, and 13 hub genes were found using cytoHubba.
[Medical Oncology] |
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| The authors used simultaneous whole-cell patch-clamp electrophysiology together with calcium imaging to investigate how enteric neurons responded to different modes of depolarisation.
[Journal of Gastrointestinal and Liver Diseases] |
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| Scientists discuss endogenous neural stem cell-induced neurogenesis after ischemic stroke and provide perspectives for the therapeutic effects of endogenous NSCs in ischemic stroke.
[Translational Stroke Research] |
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| Helixmith announced topline results today from a Phase IIA study in individuals with ALS, a fatal neurodegenerative disorder of upper and lower motor neurons that causes progressive paralysis and eventual death due to respiratory failure.
[Helixmith] |
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| October 3 – 4, 2022
San Diego, California, United States |
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| | Louisiana State University – Baton Rouge, Louisiana, United States |
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| | Max Delbrück Center for Molecular Medicine – Berlin, Germany |
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| | Lewis Katz School of Medicine, Temple University – Philadelphia, Pennsylvania, United States |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Max Delbrück Center for Molecular Medicine – Berlin, Germany |
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