 | | Vol. 16.37 – 28 September, 2022 |
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| Scientists generated a proteome atlas of the major central nervous system cell types from young and adult mice, after feeding the therapeutically relevant low-carbohydrate, high-fat ketogenic diet and during neuroinflammation.
[Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors revealed a neural projection from dorsal raphe nucleus to a startle-controlling center reticulotegmental nucleus that mediated enhanced startle response under fear condition.
[Molecular Psychiatry] |
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| Researchers showed that mouse motor neurons exhibited pervasive changes in gene expression and accessibility of associated regulatory regions from embryonic till juvenile age.
[Nature Communications] |
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| Through live imaging, the authors discovered that VAMP2/3-mediated exocytosis drives membrane expansion within myelin sheaths to initiate wrapping and power sheath elongation.
[Nature Communications] |
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| By using microglia-specific inducible mouse models overexpressing human wild-type TREM2 (TREM1-WT) or R47H risk variant, scientists showed that TREM2-WT expression reduced amyloid deposition and neuritic dystrophy only during the early amyloid seeding stage
[Journal of Experimental Medicine] |
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| Investigators identified peaks of regulatory activity within several 3′ UTRs and found that sequences derived from these peaks were both necessary and sufficient for RNA localization to neurites in mouse and human neuronal cells.
[Nucleic Acids Research] |
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| The authors reported significant upregulation of Mex-3 RNA binding family member A in bioblastoma tissues and cell lines following temozolomide treatment.
[Cancer Research] |
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| Scientists performed the first broad epigenetic profiling of myeloid-derived suppressor cells (MDSC) subsets to define underlying cell-intrinsic differences in behavior.
[Cancer Research] |
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| Investigators used patch-clamp analysis and Ca2+ and Na+ imaging to assess a rare variant in the TRPM7 channel, p.Ala931Thr, within transmembrane domain 3, identified in a man suffering from unilateral trigeminal neuralgia.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Patient neurons carrying G2019S, the most prevalent LRRK2 mutation, or R1441C each had decreased T:M ratios and pSer129 hyperphosphorylation of their endogenous αSyn along with increased phosphorylation of Rab10, a widely reported substrate of LRRK2 kinase activity.
[npj Parkinsons Disease] |
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| Researchers found relatively more excitatory synapse marker proteins in astrocytic lysosomes, whereas microglial lysosomes contained more inhibitory synapse material.
[Nature Aging] |
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| Scientists provide a brief background on Alzheimer’s disease (AD) in the context of APOE susceptibility and feature work employing hiPSC-derived brain cell and tissue models to interrogate the contribution of APOE in driving AD pathology.
[Life Science Alliance] |
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| The BRAIN Initiative, the nine-year-old, multibillion-dollar US neuroscience effort, announced its most ambitious challenge yet: compiling the world’s most comprehensive map of cells in the human brain.
[ScienceInsider] |
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| November 6 – 8, 2022
Seville, Spain |
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| | University of Limerick – Limerick, Ireland |
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| | Neurescence – Toronto, Ontario, Canada |
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| | Louisiana State University – Baton Rouge, Louisiana, United States |
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| | Max Delbrück Center for Molecular Medicine – Berlin, Germany |
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| | Lewis Katz School of Medicine, Temple University – Philadelphia, Pennsylvania, United States |
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