 | | Vol. 16.41 – 19 October, 2022 |
| | | Scientists presented human stem cell-derived cortical organoids transplanted into the somatosensory cortex of newborn athymic rats to develop mature cell types that integrated into sensory and motivation-related circuits.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | To develop in vitro models than can retain cellular features of glioma cells, a 3D-engineered scaffold, fabricated by two-photon polymerization, was developed as a cell culture model system to study patient-derived glioma cells.
[Small] |
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| Investigators elucidated the signaling pathways involved in mediating ALKBH5 protein stability in facilitating the development of glioblastomas.
[Neuro-Oncology] |
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| Scientists discovered that transcription factor homeobox A3 (HOXA3), which was aberrantly highly expressed in glioblastoma patients, transcriptionally activated aerobic glycolysis, leading to a significant acceleration in cell proliferation and tumor growth.
[Neuro-Oncology] |
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| The authors reported a patient cohort with biallelic loss-of-function variants in KIF26A, exhibiting a spectrum of congenital brain malformations.
[Developmental Cell] |
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| Investigators observed that SOX9, a transcription factor and stem cell/glial fate marker, is limited to rare, quiescent cells in high-risk medulloblastoma with MYC amplification.
[Cancer Research] |
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| Scientists identified gene dysregulation of live midbrain neurons reprogrammed in vitro from the skin cells of 42 individuals, including sporadic and familial Parkinson’s disease patients, and matched healthy controls.
[npj Parkinson’s Disease] |
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| Researchers reported developments in combining neurogenin-2 (NGN2) programming with the use of commercially available midbrain differentiation kits for directed differentiation of human-derived induced pluripotent stem cells to mature and functional induced dopaminergic neurons.
[Scientific Reports] |
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| Investigators summarize how such organoid models can complement classical approaches to accelerate neurological research.
[Nature Reviews Neurology] |
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| The authors review the role of inflammation, in particular innate immunity, in remyelination, describing its many and complex facets and discussing how our evolving understanding can be harnessed to translational goals.
[Neuron] |
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| LEXEO Therapeutics announced that the European Commission has granted orphan drug designation to LX1004 for the treatment of CLN2 Batten disease.
[LEXEO Therapeutics] |
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| November 7 – 9, 2022
Singapore, Singapore |
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| | Salk Institute for Biological Studies – San Diego, California, United States |
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| | Colgate University – Hamilton, New York, United States |
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| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
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| | Virginia Tech – Roanoke, Virginia, United States |
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| | Laval University – Quebec City, Quebec, Canada |
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