 | | Vol. 16.43 – 2 November, 2022 |
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| Researchers revealed previously unknown links between neuroinflammatory astrocytes and inflamed cerebral cavernous malformation (CCM) endothelium as contributors that trigger leukocyte recruitment and precipitate immunothrombosis in CCM lesions.
[Circulation Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators generated human knockin neurons with the NLGN3 R451C and NLGN3 null mutations. Moreover, overexpression of NLGN3 R451C recapitulated the synaptic enhancement in human neurons.
[Molecular Psychiatry] |
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| Investigators identified calmodulin-dependent kinase kinase 2 (CaMKK2) as a driver of immune checkpoint blockade resistance.
[Nature Communications] |
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| The authors elucidated an extracellular vesicles-mediated transfer of suprabasin (SBSN), leading to the aggressiveness and progression of glioma.
[Cell Death & Disease] |
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| Scientists demonstrated that, during the time course of maturation, human neurons installed a complex and complementary anti-apoptotic signaling network.
[Cell Death & Disease] |
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| Researchers determined that the most abundantly expressed anti-apoptotic Bcl-2 family members, Bcl-xL and Mcl-1, were the most relevant in regulating patient-derived glioma stem cell survival.
[Scientific Reports] |
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| Scientists focus on the role of astrocytes in disorders including Alzheimer’s disease, Parkinson’s disease, Huntington disease, and amyotrophic lateral sclerosis.
[Nature Reviews Neuroscience] |
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| The authors discuss how dysregulation of key astrocyte functions — gliotransmission, cell metabolism, and immune function — contribute to the development and progression of hyperexcitability in epilepsy.
[Nature Reviews Neurology] |
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| Tiziana Life Sciences Ltd. announced completion of enrollment of the first patient cohort in its Intermediate-Size Patient Population Expanded Access Program to evaluate foralumab in non-active Secondary Progressive Multiple Sclerosis patients, following the start of enrollment announced last week.
[Tiziana Life Sciences, Ltd.] |
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| Two of America’s biggest pharmacies have agreed to pay more than $10bn to resolve thousands of lawsuits over their roles in the US opioid crisis. The proposed deals with CVS and Walgreens mark the latest chapter of a long legal saga, in which firms have faced claims they helped drive the abuse of addictive painkillers.
[BBC News] |
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| November 14 – 17, 2022
Portland, Oregon, United States |
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| | University of Minnesota – Minneapolis, Minnesota, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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| | Texas A&M University Health Science Center – Bryan, Texas, United States |
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| | Yale University – New Haven, Connecticut, United States |
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| | Wake Forest University School of Medicine – Winston Salem, North Carolina, United States |
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