 | | Vol. 16.45 – 16 November, 2022 |
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| Researchers studied whether combining dual leucine zipper kinase deletion with a way to promote axon regeneration would result in greater motor neuron protection, demonstrating the power of combinatorial therapy to treat neurodegenerative disease.
[Brain] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists studied the morphological and transcriptional diversity of cortical cholinergic VIP/ChAT interneurons, a sparse population with a largely unknown function.
[EMBO Journal] |
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| Investigators generated induced pluripotent stem cells (iPSC) from five patients with major depressive disorders with suicidal behavior and differentiated the iPSCs into GABAergic interneurons and ventral forebrain organoids.
[EMBO Molecular Medicine] |
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| Researchers demonstrated that glioma stem cells (GSCs) lacking epidermal growth factor receptor (EGFR) amplification are exquisitely sensitive to de novo pyrimidine synthesis perturbations, while GSCs that amplify EGFR were utterly resistant.
[Oncogene] |
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| Scientists investigated the effects of the antiapoptotic peptides peptain-1 and peptain-3a on retinal ganglion cell (RGC) death in vitro in rat primary RGCs and in mouse models of ocular hypertension.
[Cell Death & Disease] |
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| Investigators presented that the induction of NANOG in neuronal cells was necessary for the physiological initiation of neuronal regeneration in response to ischemic stress.
[Experimental & Molecular Medicine] |
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| Researchers systematically assessed medium components, coatings, and growth factors required for induced pluripotent stem cell (iPSC) differentiation to microglia.
[Scientific Reports] |
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| Investigators studied whether only microglia containing a specific repeat-associated non-AUG (RAN) product, but not other RAN products, was harmful in vitro and in vivo. They demonstrated that polyL-incorporating microglia specifically led to altered startle response in mice.
[Scientific Reports] |
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| Scientists showed that hippocampal astrocyte calcium activity reflected mouse affective state during a virtual elevated plus maze test using two-photon calcium imaging in vivo.
[Brain Research] |
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| The authors provide an overview of accumulating evidence that activity-regulated myelination is required for brain adaptation and learning across multiple domains.
[Nature Reviews Neurology] |
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| Investigators summarize the research progress on the action mechanisms of Rg1 ameliorating depression-like behaviors, including inhibition of hyperfunction of the hypothalamic-pituitary-adrenal axis, regulation of synaptic plasticity, and gut flora.
[Acta Pharmacologica Sinica] |
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| INmune Bio, Inc. announced that Health Canada has issued the Company a “No Objection Letter” to proceed with the Company’s trial using XPro1595 to treat mild Alzheimer’s Disease in Canada.
[INmune Bio, Inc.] |
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| Roche announced results from the GRADUATE I and II studies evaluating gantenerumab in people with mild cognitive impairment due to Alzheimer’s and mild Alzheimer’s dementia, collectively called early Alzheimer’s disease.
[Roche] |
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| December 6 – 10, 2022
San Antonio, Texas, United States |
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| | National Institute on Drug Abuse – Baltimore, Maryland, United States |
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| | Georgia Institute of Technology – Atlanta, Georgia, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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| | Biosynth – Lelystad, Netherlands |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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