 | | Vol. 16.47 – 30 November, 2022 |
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| Scientists identified amyloid-plaque-associated axonal spheroids as prominent contributors to neural network dysfunction.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists used a stab wound injury model in zebrafish and identified an injury-induced microglial state characterized by the accumulation of lipid droplets and TAR DNA-binding protein of 43 kDa (TDP-43)+ condensates.
[Nature Neuroscience] |
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| The authors showed that human astrocytes could be directly reprogrammed into early neuroectodermal cells via the overexpression of OCT4, the suppression of p53 and the provision of the small molecules CHIR99021, SB431542, RepSox and Y27632.
[Nature Biomedical Engineering] |
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| To investigate the pathophysiology of early development in Tourette Syndrome (TS), induced pluripotent stem cell-derived basal ganglia organoids from TS patients and healthy controls were compared on multiple levels of measurement and analysis.
[Molecular Psychiatry] |
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| Scientists highlighted the importance of myeloid cells in Alzheimer’s disease (AD) and the detailed characterization across body compartments that may serve as a resource for future studies focusing on the assessment of these cells as biomarkers in AD.
[Nature Communications] |
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| Bioinformatics analysis revealed a high correlation between amyotrophic lateral sclerosis, ferroptosis, and Speedy/RINGO cell cycle regulator family member A (SPY1).
[Cell Death & Differentiation] |
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| The authors described a subset of glioblastoma, the most prevalent malignant adult brain tumor, harboring a bias towards hypomethylation at defined differentially methylated regions.
[eLife] |
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| Investigators developed a multiplex platform that automated the culture of individual organoids in isolated microenvironments at user-defined media flow rates.
[Scientific Reports] |
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| Researchers investigated whether Midazolam possessed a beneficial effect against oligomerized Aβ1.42 in SH-SY5Y neuronal cells.
[Brain and Behavior] |
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| Scientists combine tissue reconstitution and quantitative microscopy to show that tissue topology and shape are governed by two distinct modes of topological transitions.
[Nature Physics] |
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| Investigators gather clinical and translational findings related to microglial changes in schizophrenia.
[Translational Psychiatry] |
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| Opiant Pharmaceuticals, Inc. announced it had completed submission of its rolling New Drug Application (NDA) to the US FDA seeking approval for, nasal nalmefene, for the treatment of opioid overdose.
[Opiant Pharmaceuticals, Inc.] |
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| December 10 – 14, 2022
Maui, Hawaii, United States |
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| | German Centre for Neurodegenerative Diseases – Gottingen, Germany |
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| | Indiana University School of Medicine – Bloomington, Indiana, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Georgia Institute of Technology – Atlanta, Georgia, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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