 | | Vol. 16.48 – 7 December, 2022 |
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| Investigators performed an integrated analysis of 116 tumors and showed that K27M-mutant gliomas faithfully maintained chromatin configuration at developmental genes consistent with anatomically distinct oligodendrocyte precursor cells.
[Nature Genetics] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that the RNA-binding protein, Musashi-1, was an essential mediator of G3 medulloblastoma in both MYC-overexpressing mouse models and patient-derived xenografts.
[Nature Communications] |
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| Scientists presented that the Zika virus NS5, the viral RNA-dependent RNA polymerase essential for viral replication in the cytoplasm, could directly bind with chromatin DNA in the nuclei.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators showed that Piwil2 (Mili) was essential for proper neurogenesis in the postnatal mouse hippocampus.
[EMBO Reports] |
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| The authors focused on TRIM56, which emerged as the most differentially expressed tripartite motif (TRIM) family member with increased expression in glioblastoma. Western blot, real-time quantitative PCR, immunofluorescence and immunohistochemistry were used to study expression levels.
[Journal of Experimental & Clinical Cancer Research] |
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| Scientists showed that phosphofructokinase 1 platelet isoform could promote EGFR activation-induced vascular endothelial growth factor (VEGF) expression in HIF-1α-dependent and -independent manners in glioblastoma cells.
[Cell Death & Disease] |
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| N-acetyl-L-tryptophan was reported for the first time as a radioprotector against ionizing radiation in Neuro2a cells.
[Oxidative Medicine and Cellular Longevity] |
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| | To investigate the function of miR-506-3p in brachial plexus avulsion-induced neuropathic pain, a total brachial plexus root avulsion model was produced in adult rats as well as IL-1β-treated motoneuron-like NSC-34 cells and the lipopolysaccharide-treated microglia cell line BV2 for in vivo and in vitro experiments.[Developmental Neuroscience] |
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| The authors investigated whether kaempferol could protect dopaminergic neurons via autophagy and the underlying mechanisms using a MPTP/MPP+-stimulated Parkinson’s disease model.
[Neurochemical Research] |
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| Researchers review the latest advancements in improving the delivery of different therapeutic agents to the central nervous system and comment upon outstanding questions in the field of neurological lysosomal storage diseases.
[Molecular Therapy] |
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| The authors summarize emerging new concepts in the understanding of the developing human brain and discuss how these advances could be implemented in neurodevelopmental disorder models.
[Molecular Psychiatry] |
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| BioVie Inc. announced encouraging data suggesting that NE3107 had an impact on improving patients’ DNA methylation profiles, potentially impacting biomarkers of aging-related disease states.
[BioVie, Inc.] |
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| President Joe Biden signed into law a bill that streamlined access to marijuana for medical research. The new law was expected to speed the issuance of government permits to scientists who want to study cannabis, whose medicinal promise had been widely touted but remains, with a few exceptions, unproved.
[Science] |
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| January 23 – 25, 2023
Breckenridge, Colorado, United States |
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| | University of Melbourne – Melbourne, Victoria, Australia |
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| | Max Delbrück Center for Molecular Medicine – Berlin-Buch, Germany |
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| | Nencki Institute of Experimental Biology, PAS – Warsaw, Poland |
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| | German Centre for Neurodegenerative Diseases – Gottingen, Germany |
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| | Indiana University School of Medicine – Bloomington, Indiana, United States |
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