Neural Cell News Volume 17.00 | Jan 04 2023

    By
    Jamie Kang
    -
    0
    26







    2023-01-04 | NCN 17.00


    Neural Cell News by STEMCELL Technologies
    Vol. 17.00 – 4 January, 2023
    TOP STORY

    Molecular and Spatial Signatures of Mouse Brain Aging at Single-Cell Resolution

    Researchers generated a high-resolution cell atlas of brain aging within the frontal cortex and striatum using spatially resolved single-cell transcriptomics and quantified changes in gene expression and spatial organization of major cell types in these regions over the mouse lifespan.
    [Cell]

    Full ArticleGraphical Abstract
    ON1104SM-Small-Molecules-Wallchart-728x90
    PUBLICATIONSRanked by the impact factor of the journal

    Met/HGFR Triggers Detrimental Reactive Microglia in TBI

    Scientists showed Met/HGFR as a selective modifier of early microglial response and that Met/HGFR blockade prevented the induction of microglial inflammatory mediators, reactive microglia morphology, and traumatic brain injury (TBI)-associated responses in neurons and vasculature.
    [Cell Reports]

    Full ArticleGraphical Abstract

    CXCR4 Signaling Regulates Repair Schwann Cell Infiltration into the Spinal Cord after Spinal Cord Injury in Mice

    Since a recent in vitro study revealed the importance of CXCR4 signaling in Schwann cell migration, researchers investigated whether CXCR4 signaling was involved in the peripheral nervous system-to-central nervous system migration of repair Schwann cells after spinal cord injury.
    [Neuroscience Research]

    Abstract

    Intracellular Deposits of Amyloid-Beta Influence the Ability of Human iPSC-Derived Astrocytes to Support Neuronal Function

    The authors aimed to investigate how intracellular deposits of amyloid-beta (Aβ) in astrocytes affected their interplay with neurons, focusing on neuronal function and viability. For this purpose, human induced pluripotent stem cell (hiPSC)-derived astrocytes were exposed to sonicated Αβ42 fibrils.
    [Journal Of Neuroinflammation]

    Full Article

    SARS-CoV2 Entry Factors Are Expressed in Primary Human Glioblastoma and Recapitulated in Cerebral Organoid Models

    Scientists discovered that the SARS-CoV-2 virus entry factors were expressed in primary tissues and organoid models and could be potentially utilized to study the susceptibility of glioblastoma to this virus to target or modulate the tumor microenviroment.
    [Journal Of Neuro-Oncology]

    Full Article

    Aβ Efflux Impairment and Inflammation Linked to Cerebrovascular Accumulation of Amyloid-Forming Amylin Secreted from Pancreas

    Investigators presented that bloodborne islet amyloid polypeptide, amylin secreted from the pancreas perturbed cerebral amyloid-beta (Aβ) clearance in human tissues and Alzheimer’s-model rats.
    [Communications Biology]

    Full Article

    Mouse Embryonic Stem Cell-Derived Motor Neurons Are Susceptible to Ferroptosis

    Researchers used a mouse embryonic stem cell-derived motor neuron model to investigate how motor neurons responded to ferroptosis inducers.
    [FEBS Open Bio]

    Abstract

    Catalpol Mitigates Alzheimer’s Disease Progression by Promoting the Expression of Neural Stem Cell Exosomes Released miR-138-5p

    Both in vitro and in vivo experiments were employed, and found that Catalpol, the main extract of Rehmannia, could mitigate Alzheimer’s disease progression both in vitro and in vivo by promoting miR-138-5p level in neural stem cell-secreted exosomes.
    [Neurotoxicity Research]

    Full Article

    Cardiolipin Released by Microglia Can Act on Neighboring Glial Cells to Facilitate the Uptake of Amyloid-β (1– 42)

    Scientists demonstrated a feed-forward mechanism wherein Aβ42 could induce the release of cardiolipin from microglia, which in turn facilitated the endocytosis of Aβ42 by astrocytes and microglia.
    [Molecular And Cellular Neuroscience]

    Abstract
    ISSCR 2022 Neural Cell Culture Model Webinar - 728x90
    REVIEWS

    Insights into Alzheimer’s Disease from Single-Cell Genomic Approaches

    Investigators highlight cell-type-specific molecular perturbations in Alzheimer’s disease (AD). They discuss how genomic information from single cells expands existing paradigms of AD pathogenesis and highlight new opportunities for therapeutic interventions.
    [Nature Neuroscience]

    Full Article

    Neuro-Orchestration of Sleep and Wakefulness

    The authors present recent progress and summarize the current understanding of the circuitry underlying the initiation, maintenance, and coordination of wakefulness, rapid eye movement sleep (REMS) and non-REMS.
    [Nature Neuroscience]

    Full Article
    INDUSTRY AND POLICY NEWS

    Tiziana
    Life Sciences Announces Additional Clinical Improvements in the Second Patient with Non-Active Secondary Progressive Multiple Sclerosis (SPMS) After Eleven Months of Dosing with Intranasal Foralumab

    Tiziana Life Sciences, Ltd. announced that the second patient with non-active SPMS receiving intranasal foralumab had shown additional clinical improvements since their last reported improvement in September 2022.
    [Tiziana Life Sciences, Ltd.]

    Press Release
    FEATURED EVENT

    Organoids as Models of Development and Disease, and Their Impact on Drug Discovery

    February 5 – 8, 2023
    Keystone, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Tissue Regeneration Engineering

    Dankook University – Seoul, South Korea

    Clinical Research Fellow – Motor Neuron Disease

    University of Oxford – Oxford, England, United Kingdom

    Postdoctoral Fellow – Neural Engineering

    Harvard University – Cambridge, Massachusetts, United States

    Postdoctoral Scientist – Cancer Therapeutics

    UTHSC-Houston – Houston, Texas, United States

    Faculty Positions – Translational Biomedical Research

    Rutgers Biomedical and Health Sciences – Newark, New Jersey, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Neural Cell News Twitter