 | | Vol. 17.01 – 11 January, 2023 |
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| Researchers found that dsRNA and dsRNA sensing machinery were elevated in astrocytes of postmortem brain tissue from patients with Alzheimer’s disease, progressive supranuclear palsy, and in brains of tau transgenic mice.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists revealed that AT7519 induced apoptosis and pyroptosis, and exhibited antitumor activity in intracranial and subcutaneous xenografted nude mice, indicating that AT7519 represented a potentially effective small molecule targeted drug for the treatment of glioblastoma.
[Cell Death & Disease] |
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| Investigators determined the facilitative effect of endothelial cells-derived exosomes on Schwann cells and sought the underlying mechanism.
[Journal Of Nanobiotechnology] |
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| The authors demonstrated physiological electric field stimulation as an efficient method to boost the neuronal differentiation of neural stem cells via the PI3K/Akt/GSK-3β/β-catenin activation.
[Cell & Bioscience] |
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| The cytochrome P450 and UDP-glucuronosyltransferase-dependent metabolism of efavirenz was probed in brain microsomes from mice, cynomolgus macaques, and humans as well as primary neural cells from C57BL/6N mice.
[Drug Metabolism And Disposition] |
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| Researchers analyzed the presence and significance of the HDAC1/REST complex’s regulatory effect in the expression of multiple neuronal genes in glioma based on bioinformatics methods.
[World Neurosurgery] |
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| The protective effect of hesperidin methylchalcone was evaluated through Alzheimer’s disease models of Neuro-2a cells and Wistar rats. The in vitro results showed that HMC possessed a significant ability to inhibit the acetylcholinesterase enzyme and exhibited anti-aggregation and disaggregation properties.
[International Journal Of Biological Macromolecules] |
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| Scientists investigated the effects of Au nanoparticles on human neural stem cells viability, and proinflammatory factors, by Cell Counting Kit-8 and enzyme-linked immunosorbent assays.
[Neurotoxicology] |
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| Using a focal demyelination model in the brain, investigators demonstrated that demyelination was persistent in triggering receptor expressed on myeloid cells 2 (TREM2) in knockout mice, lasting more than 6 weeks after lysolecithin injection, and resulted in substantial neurodegeneration.
[Glia] |
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| The authors summarize current knowledge on the multifunctional contributions of microglia to homeostasis and their involvement in neurodegeneration.
[Neuroscience Bulletin] |
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| Theriva Biologics announced that the first patient had been dosed in the Phase I investigator-sponsored clinical trial of VCN-01, an intravenous oncolytic adenovirus, for patients with high-grade brain tumors who were scheduled for surgical resection.
[Theriva Biologics] |
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| The US FDA approved a controversial Alzheimer’s disease treatment for broad use—with caveats. The drug, an antibody called lecanemab, is the first to clearly slow cognitive decline in patients with early-stage disease, fueling excitement in the Alzheimer’s field and hope for patients and families.
[Science Insider] |
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| February 5 – 8, 2023
Keystone, Colorado, United States |
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| | Human Technopole – Milan, Italy |
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| | Upstate Medical University – Syracuse, New York, United States |
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| | Shanghai Clinical Research and Trial Center – Shanghai, China |
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| | Stanford Medicine – Stanford, California, United States |
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| | Van Andel Research Institute – Grand Rapids, Michigan, United States |
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