Neural Cell News Volume 17.03 | Jan 25 2023

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    2023-01-25 | NCN 17.03


    Neural Cell News by STEMCELL Technologies
    Vol. 17.03 – 25 January, 2023
    TOP STORY

    Human Early-Onset Dementia Caused by DAP12 Deficiency Reveals a Unique Signature of Dysregulated Microglia

    Single-nucleus RNA-sequencing analysis of brain specimens from DAP12-deficient Nasu-Hakola disease individuals revealed a unique microglia signature indicating heightened RUNX1, STAT3, and transforming growth factor-β signaling pathways that mediated repair responses to injuries.
    [Nature Immunology]

    Full Article
    Survey results on the insights and hurdles of CRISPR genome editing.
    PUBLICATIONSRanked by the impact factor of the journal

    Pyramidal Cell Types Drive Functionally Distinct Cortical Activity Patterns during Decision-Making

    Scientists used genetic and retrograde labeling to target pyramidal tract, intratelencephalic and corticostriatal projection neurons, and measured their cortex-wide activity.
    [Nature Neuroscience]

    Full Article

    A Bio-Orthogonal Linear Ubiquitin Probe Identifies STAT3 as a Direct Substrate of OTULIN in Glioblastoma

    Investigators presented a live cell-compatible bio-orthogonal strategy to capture the direct linear polyUbiquitin-modified substrates. They constructed a linear Ubiquitin (Ub)-specific probe by internally incorporating a non-canonical amino acid into Ub via genetic code expansion.
    [Nucleic Acids Research]

    Full Article
    Graphical Abstract

    Cross-Species Transcriptomic Atlas of Dorsal Root Ganglia Reveals Species-Specific Programs for Sensory Function

    The authors described a protocol for the isolation of dorsal root ganglion (DRG) nuclei from multiple species, provided a single-nucleus transcriptome atlas of DRG from samples, and characterized transcriptional similarities and differences of sensory neuron subtypes from rodents to humans.
    [Nature Communications]

    Full Article

    Post-transcriptional Control of a Stemness Signature by RNA-Binding Protein MEX3A Regulates Murine Adult Neurogenesis

    Investigators identified RNA-binding protein MEX3A as a post-transcriptional regulator of a set of stemness-associated transcripts at critical transitions in the subependymal neurogenic lineage.
    [Nature Communications]

    Full Article

    Transcriptional and Functional Effects of Lithium in Bipolar Disorder iPSC-Derived Cortical Spheroids

    Since brain cortex abnormalities are strongly associated with bipolar disorder (BD), scientists specifically generated induced pluripotent stem cell-derived human cortical spheroids from healthy controls and BD patients and studied the effects of lithium treatments at the transcriptional and functional level.
    [Molecular Psychiatry]

    Full Article

    Reversibility and Developmental Neuropathology of Linear Nevus Sebaceous Syndrome Caused by Dysregulation of the RAS Pathway

    Investigators showed that the introduction of KRASG12V in the developing mouse cortex resulted in subcortical nodular heterotopia and enhanced excitability, recapitulating major pathological manifestations of linear nevus sebaceous syndrome.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Altered Energy Metabolism in Fatal Familial Insomnia Cerebral Organoids Is Associated with Astrogliosis and Neuronal Dysfunction

    Using CRISPR-Cas9 engineered induced pluripotent stem cells, researchers made D178N cerebral organoids and compared these with isotype control organoids.
    [Plos Genetics]

    Full Article

    Systematic Comparison of Culture Media Uncovers Phenotypic Shift of Primary Human Microglia Defined by Reduced Reliance to CSF1R Signaling

    Investigators studied the functional and transcriptomic impacts of such media on human microglia (hMGL). They provided a better understanding of hMGL in culture, with observations that diverged from those previously made in rodent microglia.
    [Glia]

    Full Article
    A Labroots 2021 Webinar: iPSCs As Models, Part 2: Modeling the Human Brain with Organoids, presented by Dr. Anjana Nityanandam, Director of the Human Stem Cell Lab core facility at St. Jude Children’s Research Hospital. Click to Watch Now.
    REVIEWS

    Development, Wiring and Function of Dopamine Neuron Subtypes

    Scientists discuss recent advances in our understanding of molecularly defined midbrain dopamine neuron subtypes and their circuits, ranging from early developmental events, such as neuron migration and axon guidance, to their wiring and function, and future implications for therapeutic strategies.
    [Nature Reviews Neuroscience]

    Abstract

    Immune Checkpoint Blockade in Glioblastoma: From Tumor Heterogeneity to Personalized Treatment

    The authors discuss contributing factors that distinguish subsets of patients with glioma who may benefit from immune checkpoint blockade.
    [Journal Of Clinical Investigation]

    Full Article
    INDUSTRY AND POLICY NEWS

    Cassava Sciences Announces Positive Top-Line Clinical Results in Phase II Study Evaluating Simufilam in Alzheimer’s Disease

    Cassava Sciences, Inc. announced positive top-line Phase II results for simufilam, its oral drug candidate for Alzheimer’s disease dementia. The study enrolled over 200 patients with mild-to-moderate Alzheimer’s disease.
    [Cassava Sciences, Inc.]

    Press Release
    FEATURED EVENT

    4th Growth Factors in Regeneration and Regenerative Medicine Conference

    February 9 – 12, 2023
    Cancun, Mexico

    > See All Events

    JOB OPPORTUNITIES

    Faculty Position – Pediatric Neurosciences

    Emory University – Atlanta, Georgia, United States

    Research Associate – Regenerative Therapies

    Dresden University of Technology – Dresden, Germany

    Lab Technician – CRISPR-Cas9 in Neuroimmunology

    The University of Luxembourg – Belval, Luxembourg

    Associate Professor – Neuroimmunology & Neuroinflammation

    The University of Luxembourg – Belval, Luxembourg

    Postdoctoral Scientist – Cell Biology

    MRC National Institute for Medical Research – Cambridge, England, United Kingdom

    > See All Jobs

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