 | | Vol. 17.04 – 01 February, 2023 |
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| ZAAM, an antisense oligonucleotide-loaded, aptamer Apt 19S-conjugated, neural stem cell membrane-coated nanoparticle, was developed for the targeted treatment of Parkinson’s disease.
[ACS Nano] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators reported that mitochondrial metabolic pathways were suppressed in radioresistant gliomas through integrated analyses of transcriptomic data from glioma specimens and cell lines.
[Cancer Research] |
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| Researchers used CRISPR interference to knock down TERT expression in TERT promoter-mutant glioblastoma cell lines and patient-derived models. They then measured viability using serial proliferation assays.
[Neuro-Oncology] |
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| Investigators studied the effect of Schwann cell-derived exosomes on regulating the inflammation related to macrophage polarization during the recovery of spinal cord injury.
[Cell Death & Disease] |
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| The authors demonstrated that light stimulation of opto-cannabinoid receptor 1 (CB1R) triggered canonical CB1R signaling by inhibiting cAMP, but not cGMP or IP1, signaling and activating the MAPK pathway in vitro or in vivo.
[Neuropsychopharmacology] |
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| Scientists revealed that exogenous irisin conferred neuroprotection relieving apoptosis and oxidative stress, restraining mitochondrial fragmentation, and promoting mitochondrial respiration and biogenesis in Parkinson’s disease models.
[Cell Death Discovery] |
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| The authors studied the functional and transcriptomic impacts of such media on human microglia (hMGL). They provided a better understanding of hMGL in culture, with observations that diverged from those previously made in rodent microglia.
[NPJ Parkinson’s Disease] |
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| Researchers explored the metabolic features characterizing MYC-driven medulloblastoma and examined how these were altered by BET-bromodomain inhibition.
[Scientific Reports] |
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| Scientists built a protein-protein interaction network for 13 autism spectrum disorder-associated genes in human excitatory neurons derived from induced pluripotent stem cells.
[Cell Genomics] |
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| Investigators summarize the evidence for key psychological and biological mechanisms linking experiences of trauma with cardiovascular disease risk. Additionally, they describe various methodologies for measuring these mechanisms in an effort to inform future research related to potential pathways.
[Translational Psychiatry] |
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| Eisai Co., Ltd. and Biogen Inc. announced that the European Medicines Agency had accepted a marketing authorization application for lecanemab, an investigational anti-amyloid beta protofibril antibody, for the treatment of early Alzheimer’s disease with confirmed amyloid pathology.
[Biogen, Inc.] |
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| February 13 – 16, 2023
Breckenridge, Colorado, United States |
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| | The Johns Hopkins Wilmer Eye Institute – Baltimore, Maryland, United States |
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| | University of Bordeaux – Paris, France |
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| | Karolinksa Institutet – Stockholms, Sweden |
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| | Emory University – Atlanta, Georgia, United States |
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| | University of Melbourne – Melbourne, Victoria, United States |
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