 | | Vol. 17.05 – 08 February, 2023 |
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| Scientists reported that secreted phosphoprotein 1 (SPP1) was upregulated predominantly by perivascular macrophages and, to a lesser extent, by perivascular fibroblasts.
[Nature Neuroscience] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers recapitulated the known pattern of LINE-1 expression in tumors—present in cancer cells, absent from immune cells—and identified hitherto undescribed LINE-1 expression in human epithelial cells and mouse hippocampal neurons.
[Nucleic Acids Research] |
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| Investigators studied the function of SMPD4 at the cellular and organ levels. Knock-down of SMPD4 in human neural stem cells caused reduced proliferation rates and prolonged mitosis.
[Brain] |
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| Scientists generated induced pluripotent stem cells (iPSCs) from tyrosine hydroxylase deficiency (THD) patients that were differentiated into dopaminergic neurons (DAn) and compared with control-DAn from healthy individuals and gene-corrected isogenic controls.
[EMBO Molecular Medicine] |
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| Investigators provided novel insights into how WFS1 deficiency affected synapse formation and function, and offered a strategy to treat wolfram syndrome.
[Molecular Psychiatry] |
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| The authors described the synthesis and biological evaluation of small molecule CD38 inhibitors and demonstrated their potential utility as a novel approach to neuroblastoma immunotherapy.
[Chemical Science] |
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| Scientists uncovered a new noncanonical function of enhancer of zeste homolog 2 (EZH2) in multiple myeloma (MM) tumorigenesis and provided a novel therapeutic strategy, pharmacological degradation of EZH2, for treating EZH2-dependent MM.
[Oncogene] |
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| Researchers induced patient-derived microglia-like cells (iMGs) to clarify the molecular characteristics and function of panic disorder-iMGs.
[Translational Psychiatry] |
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| Investigators explored whether osteocalcin (OCN) could ameliorate the cognitive dysfunctions in a mouse model of Alzheimer’s disease (AD) and investigated the potential mechanisms, trying to expand the endocrine functions of OCN and providing a new dimension for the treatment of AD.
[Cell Death Discovery] |
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| The authors emphasize the role of peripheral immune cells in Alzheimer’s disease (AD) and the mechanisms by which immune cells influence AD neuropathology, including the pro-inflammatory and cytotoxic activity of microglia, astrogliosis, and their interactions with the brain vasculature.
[Genome Medicine] |
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| Investigators review the fabrication of nanomaterial-based microelectrode arrays applied to bidirectional in vitro brain-computer interfaces from an interdisciplinary perspective.
[Microsystems & Nanoengineering] |
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| Japanese drugmaker Eisai reported the first US sales of Leqembi, its treatment for Alzheimer’s disease, although exact numbers were not provided and people taking the drug appear to be paying out of pocket because insurance coverage had not yet been established.
[Stat] |
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| Denali Therapeutics Inc. announced that its partner Sanofi had commenced dosing in a Phase II study of SAR443820 in individuals with multiple sclerosis. SAR443820 is a central nervous system-penetrant investigational small molecule inhibitor of RIPK1.
[Denali Therapeutics, Inc.] |
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| February 22 – 23, 2023
Boston, Massachusetts, United States |
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| | Newcastle University – Newcastle, England |
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| | University of Mississippi Medical Center – Jackson, Mississippi, United States |
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| | Texas Medical Center – Houston, Texas, United States |
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| | Karolinksa Institutet – Stockholms, Sweden |
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| | The Johns Hopkins Wilmer Eye Institute – Baltimore, Maryland, United States |
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