Neural Cell News Volume 17.08 | Mar 01 2023

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    Jamie Kang
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    2023-03-01 | NCN 17.08


    Neural Cell News by STEMCELL Technologies
    Vol. 17.08 – 1 March, 2023
    TOP STORY

    A Neurodevelopmental Epigenetic Program Mediated by SMARCD3–DAB1–Reelin Signaling Is Hijacked to Promote Medulloblastoma Metastasis

    Researchers uncovered a neurodevelopmental epigenomic program that was hijacked to induce medulloblastoma metastatic dissemination
    [Nature Cell Biology]

    Full Article
    728x90_2023C1-KSAutophagy23
    PUBLICATIONSRanked by the impact factor of the journal

    PDLIM3 Supports Hedgehog Signaling in Medulloblastoma by Facilitating Cilia Formation

    Scientists found that PDLIM3 expression was necessary for hedgehog pathway activation in medulloblastoma cells.
    [Cell Death & Differentiation]

    Abstract

    Glioblastoma Upregulates SUMOylation of hnRNP A2/B1 to Eliminate the Tumor Suppressor miR-204-3p, Accelerating Angiogenesis under Hypoxia

    Researchers found miRNAs sorted into glioma exosomes and revealed the sorting process. They found that miR-204-3p suppressed tumors via the CACNA1C/MAPK pathway in glioblastoma cells
    [Cell Death & Differentiation]

    Full Article

    APC/C-dependent Degradation of Spd2 Regulates Centrosome Asymmetry in Drosophila Neural Stem Cells

    Using an in vitro screen for centrosomal substrates of the APC/C ubiquitin ligase in Drosophila, scientists identified several conserved pericentriolar material (PCM) components, including the inner PCM protein Spd2.
    [EMBO Reports]

    Full ArticleGraphical Abstract

    Generation of Human Otic Neuronal Organoids Using Pluripotent Stem Cells

    Investigators developed a protocol to generate human otic neuronal organoids from human pluripotent stem cells (hESCs), in which hESCs were step-wisely induced to spiral ganglion neurons of the corresponding stages according to their developmental trajectory.
    [Cell Proliferation]

    Full Article

    Granulin Loss of Function in Human Mature Brain Organoids Implicates Astrocytes in TDP-43 Pathology

    Researchers presented a 3D induced pluripotent stem cell-derived paradigm, mature brain organoids, composed of cortical-like-astrocytes and neurons, and used these organoids to model TAR-DNA binding protein 43-related pathology.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Mitochondrial Hydrogen Peroxide Activates PTEN and Inactivates Akt Leading to Autophagy Inhibition-Dependent Cell Death in Neuronal Models of Parkinson’s Disease

    Investigators showed that treatment with 6-OHDA, MPP+, or rotenone triggered decreases of ATG5/LC3-II and autophagosome formation with a concomitant increase of p62 in PC12, SH-SY5Y cells, and primary neurons, suggesting inhibition of autophagy.
    [Molecular Neurobiology]

    Abstract

    Neuroprotection by Nrf2 via Modulating Microglial Phenotype and Phagocytosis after Intracerebral Hemorrhage

    Researchers investigated the mechanism underlying Nrf2-mediated regulation of microglial phenotype and phagocytosis in hematoma clearance after intracerebral hemorrhage.
    [Heliyon]

    Full Article

    Glioblastoma Cell-Derived Exosomes Induce Cell Death and Oxidative Stress in Primary Cultures of Olfactory Neurons. Role of Redox Stress

    Scientists studied whether glioblastoma-originated exosomes played a role in olfactory nerve cell toxicity.
    [Molecular Biology Reports]

    Abstract
    Watch this webinar to learn about the role of microglia in mechanisms of immune activation to Alzheimer's pathology.
    REVIEWS

    Glia Connect Inflammation and Neurodegeneration in Multiple Sclerosis

    The authors focus on the role of glial cells, including microglia, astrocytes, and oligodendrocytes, in the pathogenesis of multiple sclerosis.
    [Neuroscience Bulletin]

    Abstract
    INDUSTRY AND POLICY NEWS

    Ocean Biomedical (NASDAQ: OCEA) Celebrates Discovery of Bispecific Antibodies and Immune Checkpoint Inhibitors That Kill Glioblastoma Cells and Melanoma Cells, and Block the Metastasis of Malignant Melanoma Cells to the Lung by Over 90%

    Ocean Biomedical, Inc. celebrated the discovery of bispecific antibodies that target Chitinase 3-like-1 and immune checkpoint inhibitors, killing glioblastoma cells and melanoma cells, and blocking the metastasis of malignant melanoma cells to the lung by over 90%.
    [Ocean Biomedical, Inc. (Globe Newswire)]

    Press Release

    Roche Launches Two New Antibodies to Identify Key Clinical Mutations in Patients with Brain Cancer

    Roche announced the launch of the IDH1 R132H Rabbit Monoclonal Primary Antibody and the ATRX Rabbit Polyclonal Antibody to identify mutation status in patients diagnosed with brain cancer.
    [Roche]

    Press Release
    FEATURED EVENT

    AACR Special Conference: Advances in Prostate Cancer Research

    March 15 – 18, 2023
    Denver, Colorado, United States

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    JOB OPPORTUNITIES

    Master Thesis – Spiking Neural Networks

    Julich Research Centre – Julich, Germany

    Research Technologist – Neural & Behavourial Sciences

    Pennsylvania State University – State College, Pennsylvania, United States

    Postdoctoral Position – Experimental Neurogeriatrics

    Karolinksa Institutet – Solna, Sweden

    Postdoctoral Research Associate – Mitochondrial Dynamics

    Washington University School of Medicine – St. Louis, Missouri, United States

    Postdoctoral Position – Neural Tissue Engineering

    Aarhus University – Aarhus, Denmark

    > See All Jobs

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