 | | Vol. 17.09 – 8 March, 2023 |
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| Scientists reported that PIEZO2 activity was reduced in female human induced pluripotent stem cell-derived sensory neurons with UBE3A knock-down, and de-identified stem cell-derived neurons from individuals with Angelman syndrome.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers identified the AUAG motif and the AGAA tetraloop in the Xrn1-resistant RNA 2 as the canonical and non-canonical MSI1 binding sites, respectively, and both are crucial for Zika virus neurotropism.
[Nature Communications] |
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| Investigators established a human 3D in vitro model of maternal immune activation by treating induced pluripotent stem cell-derived dorsal forebrain organoids with a constitutively active form of IL-6, Hyper-IL-6.
[Molecular Psychiatry] |
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| The authors provided insights into the mechanisms through which tripartite motif containing 56 (TRIM56) promoted glioma motility, by regulating IQGAP1 ubiquitination to promote CDC42 activation, which may be clinically targeted for the treatment of glioma.
[Cell Death & Disease] |
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| Scientists provided evidence that caspase-dependent apoptotic cell death of neural stem and progenitor cells was required for sending survival signals to the injured brain.
[Cell Death & Disease] |
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| Investigators employed in vivo proximity labeling, in the mouse, using unfused BirA to generate the first subcellular proteome of radial glial cells and uncovered new principles governing local control of cortical development.
[PLOS Biology] |
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| Through the tandem mass tag-based quantitative proteomic analysis of clinical primary and recurrent glioma samples, scientists identified that aberrant E3 ligase MAEA was expressed in recurrent samples.
[Oncogene] |
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| Investigators found that the deterioration in the level and content of consciousness after traumatic brain injury was associated with a large reduction in glutamatergic neurons within the paraventricular thalamus and claustrum.
[CNS Neuroscience & Therapeutics] |
| | To replicate in vivo and in vitro cerebral ischemia/reperfusion injury, a transient middle cerebral artery occlusion model in rats and an oxygen-glucose deficiency/reoxygenation model in neuro 2A cells were developed.
[Cell Reports Methods] |
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| The authors review the potential role of diclofenac and non-steroidal anti-inflammatory drugs in the fenamate group for targeting Alzheimer’s disease pathology with a focus on its potential effects on microglia.
[Therapeutic Advances In Neurological Disorders] |
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| Trevena, Inc. announced the initiation of a Phase I proof-of-concept study of TRV045, a novel sphingosine-1-phosphate receptor modulator selective for the S1P receptor subtype 1.
[Trevena, Inc.] |
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| March 19 – 21, 2023
Sitges, Spain |
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| | Vrije Universiteit Amsterdam – Amsterdam, Netherlands |
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| | Weill Cornell College of Medicine – New York, New York, United States |
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| | University of Luxembourg – Esch-sur-Alzette, Luxembourg |
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| | Julich Research Centre – Julich, Germany |
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| | Pennsylvania State University – State College, Pennsylvania, United States |
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