 | | Vol. 17.10 – 15 March, 2023 |
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| Using genetic tools that broadly covered a peripheral sensory neuron atlas, scientists identified a small population of prostaglandin E2 -detecting glossopharyngeal sensory neurons that were essential for influenza-induced sickness behavior in mice.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers compared the immunological milieux in the brain of mice with amyloid deposition or tau aggregation and neurodegeneration, to investigate the role of the adaptive immune response and its interaction with the innate immune response in the presence of amyloid-β or tau pathology.
[Nature] |
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| Scientists identified SOX11 as a dependency transcription factor in adrenergic neuroblastoma based on recurrent chromosome 2p focal gains and amplifications, specific expression in the normal sympatho-adrenal lineage, and strong dependency on high SOX11 expression in adrenergic neuroblastomas.
[Nature Communications] |
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| Investigators suggested that endothelial Arid1a tightly controls the fate determination of neural progenitor cells by regulating the AKT-SMAD signaling pathway.
[Cell Proliferation] |
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| Researchers investigated the existence and function of Growth hormone secretagogue receptor 1a/dopamine type 2 receptor (GHS-R1a/D2R) heterodimers in nigral dopaminergic neurons in Parkinson’s disease models in vitro and in vivo.
[Acta Pharmacologica Sinica] |
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| Scientists observed that the cGAS-STING pathway was activated during neuroinflammation in MPTP mouse models of Parkinson’s diease.
[CNS Neuroscience & Therapeutics] |
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| Investigators determined the threshold of regional specific binding ratio (SBR) for discriminating Nigrosome 1 (NG1) visibility and the probability for NG1 visibility according to regional SBR.
[European Journal Of Neurology] |
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| Researchers showed significant in vitro and in vivo Verteporfin–induced suppression of neuroblastoma growth, making Verteporfin a potential therapeutic candidate against neuroblastomas.
[Scientific Reports] |
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| Scientists demonstrated that coexpression patterns from 993 human postmortem brains were significantly correlated with the transcriptional consequences of CRISPR perturbations in human neurons.
[Cell Genomics] |
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| The authors overview the current knowledge acquired from studies of brains modeling six identified single genes, their limitations, and directions for future research that may redefine schizophrenia based on biological alterations in the responsible organ rather than operationalized criteria.
[Molecular Psychiatry] |
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| SciSparc Ltd. announced the approval of the Israeli Ministry of Health to conduct its clinical trial titled “A randomized, double-blind, placebo-controlled, cross-over study to evaluate the efficacy, safety and tolerability of daily oral SCI-110 in treating adults with Tourette Syndrome”.
[SciSparc, Ltd.(Globe Newswire, Inc.)] |
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| March 26 – 29, 2023
Snowbird, Utah, United States |
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| | Dana-Farber Cancer Institute – Bostona, Massachusetts, United States |
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| | Swiss Federal Institute of Technology Lausanne – Lausanne, Switzerland |
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| | University of Southern California – Los Angeles, California, United States |
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| | Weill Cornell College of Medicine – New York, New York, United States |
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| | University of Luxembourg – Esch-sur-Alzette, Luxembourg |
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