Neural Cell News Volume 17.11 | Mar 22 2023

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    Jamie Kang
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    2023-03-22 | NCN 17.10


    Neural Cell News by STEMCELL Technologies
    Vol. 17.11 – 22 March, 2023
    TOP STORY

    Spatial Epigenome–Transcriptome Co-Profiling of Mammalian Tissues

    To further investigate the epigenetic mechanisms underlying gene expression regulation, scientists developed spatially resolved, genome-wide comapping of the epigenome and transcriptome by simultaneous profiling of chromatin accessibility and messenger RNA expression.
    [Nature]

    Full ArticlePress Release
    Virtual Conference Exhibition: Pluripotent Stem Cells
    PUBLICATIONSRanked by the impact factor of the journal

    Purification and Characterization of Human Neural Stem and Progenitor Cells

    Researchers described a method for prospectively isolating ten distinct neural stem and progenitor cell types from the developing human brain using cell-surface markers.
    [Cell]

    Full ArticlePress ReleaseGraphical Abstract

    Mechanism of STMN2 Cryptic Splice-Polyadenylation and Its Correction for TDP-43 Proteinopathies

    Scientists determined that TDP-43 binding in the first intron of the STMN2 pre-mRNA sterically blocked access of RNA processing factors that would otherwise recognize and use a cryptic 3′ splice site.
    [Science]

    AbstractPress Release

    Upregulation of SYNGAP1 Expression in Mice and Human Neurons by Redirecting Alternative Splicing


    Investigators characterized an alternative 3′ splice site (A3SS) of SYNGAP1 that induced nonsense-mediated mRNA decay in mouse and human neural development. They demonstrated that PTBP1/2 directly bound to and promoted SYNGAP1 A3SS inclusion.
    [Neuron]

    Full ArticleGraphical Abstract

    Cellular Mechanisms of Heterogeneity in NF2-Mutant Schwannoma

    Researchers found that loss of the membrane:cytoskeleton-associated neurofibromatosis type 2 (NF2) tumor suppressor, merlin, yielded unstable intrinsic polarity and enabled Nf2-/- Schwann cells to adopt distinct programs of ErbB ligand production and polarized signaling.
    [Nature Communications]

    Full Article

    Quinolinate Promotes Macrophage-Induced Immune Tolerance in Glioblastoma through the NMDAR/PPARγ Signaling Axis

    Using global metabolomic profiling of patient-derived brain tumors, investigators identified the downstream metabolism of tryptophan and accumulation of quinolinate as a metabolic node in glioblastoma and demonstrate its critical role in promoting immune tolerance.
    [Nature Communications]

    Full Article

    HSV-1 Cellular Model Reveals Links between Aggresome Formation and Early Step of Alzheimer’s Disease

    Using neuronal cells expressing the wild type form of amyloid precursor protein infected by  herpes simplex virus type-1 (HSV-1), scientists characterized a representative cellular model of the early stage of the sporadic form of the disease and unraveled a mechanism sustaining this HSV-1- Alzheimer’s interplay.
    [Translational Psychiatry]

    Full Article

    iPSC-Derived Neural Precursor Cells Engineering GBA1 Recovers Acid β-Glucosidase Deficiency and Diminishes α-Synuclein and Neuropathology

    Researchers evaluated a cell therapy treatment using mouse-induced pluripotent stem cell-derived (iPSC) neural precursor cells engineered to overexpress lysosomal acid β-glucosidase.
    [Molecular Therapy-Methods & Clinical Development]

    Full ArticleGraphical Abstract

    Ginsenoside Rg1 Attenuates Cerebral Ischemia-Reperfusion Injury through Inhibiting the Inflammatory Activation of Microglia

    Investigators reported that ginsenoside Rg1 effectively suppressed the inflammatory activation of brain microglia cells under cerebral ischemia/reperfusion conditions depending on the inhibition of Toll-like receptor4 proteins.
    [Experimental Cell Research]

    Abstract
    Explore neural organoid technologies with this free wallchart from STEMCELL and Nature Neuroscience
    REVIEWS

    Shaping the Brain Vasculature in Development and Disease in the Single-Cell Era

    The authors review the current knowledge of general and central nervous system-specific mechanisms of angiogenesis during brain development and in brain vascular malformations and brain tumors, including how key molecular signaling pathways are reactivated in vascular-dependent diseases.
    [Nature Reviews Neuroscience]

    Full Article

    Friend or Foe: Role of Pathological Tau in Neuronal Death

    Scientists briefly describe the current understanding of how pathological tau exerts dual effects on neuronal death by acting as a double-edged sword in different neurological diseases.
    [Molecular Psychiatry]

    Abstract
    INDUSTRY AND POLICY NEWS

    Novartis Tafinlar + Mekinist Approved by FDA for Pediatric Patients with BRAF V600E Low-Grade Glioma, the Most Common Pediatric Brain Cancer

    Novartis announced the US FDA granted approval for Tafinlar® + Mekinist® for the treatment of pediatric patients 1 year of age and older with low-grade glioma with a BRAF V600E mutation who require systemic therapy.
    [Novartis]

    Press Release
    FEATURED EVENT

    AACR Annual Meeting 2023

    April 14 – 19, 2023
    Orlando, Florida, United States

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    JOB OPPORTUNITIES

    Postdoctoral Position – Cognitive Neuroscience

    University of Amsterdam – Amsterdam, Netherlands

    Associate Research Scientists – Cancer Genetics

    Columbia University – New York City, New York, United States

    Staff Scientist – Pediatric Brain Tumors

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Fellow – Cancer and Neurodegenerative Diseases

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Postdoctoral Position – Soft Implantable Neural Systems

    Swiss Federal Institute of Technology Lausanne – Lausanne, Switzerland

    > See All Jobs

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