Neural Cell News Volume 17.12 | Mar 29 2023

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    Jamie Kang
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    2023-03-28 | NCN 17.12


    Neural Cell News by STEMCELL Technologies
    Vol. 17.12 – 29 March, 2023
    TOP STORY

    Mapping of Clonal Lineages across Developmental Stages in Human Neural Differentiation

    Investigators developed single-cell split barcoding (SISBAR) that allowed clonal tracking of single-cell transcriptomes across stages in an in vitro model of human ventral midbrain-hindbrain differentiation.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract
    PUBLICATIONSRanked by the impact factor of the journal

    Immunotherapy Targeting Plasma ASM Is Protective in a Mouse Model of Alzheimer’s Disease

    Researchers explored plasma acid sphingomyelinase (ASM) as a circulating factor that accelerated neuropathological features in Alzheimer’s disease by exposing young APP/PS1 mice to the blood of mice overexpressing ASM, through parabiotic surgery.
    [Nature Communications]

    Full Article

    IGFBP5 Is an ROR1 Ligand Promoting Glioblastoma Invasion via ROR1/HER2-CREB Signaling Axis

    Scientists reported Insulin-like Growth Factor-Binding Protein 5 (IGFBP5), a ligand for Receptor tyrosine kinase like Orphan Receptor 1 (ROR1), as a promising target for glioblastoma stem-like cell invasion.
    [Nature Communications]

    Full Article

    SREBP2 Maintains Glioblastoma Stem Cells through Keeping the Balance between Cholesterol Biosynthesis and Uptake Get Access Arrow

    Researchers investigated the adaptive behavior of glioblastoma stem cells under different cholesterol supplies by conducting in vitro loss-of-function genetic and pharmacologic assays to evaluate the effect of Sterol Regulatory Element-Binding Protein 2 (SREBP2).
    [Neuro-Oncology]

    Abstract

    Fatostatin Induces Ferroptosis through Inhibition of the AKT/mTORC1/GPX4 Signaling Pathway in Glioblastoma

    Through transcriptome sequencing, in vivo experiments, and in vitro experiments, investigators found that fatostatin induces ferroptosis by inhibiting the AKT/mTORC1/GPX4 signaling pathway in glioblastoma.
    [Cell Death & Disease]

    Full Article

    DOPAL Initiates αSynuclein-Dependent Impaired Proteostasis and Degeneration of Neuronal Projections in Parkinson’s Disease

    The authors demonstrated that dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) elicited αSynuclein (αSyn) accumulation and hampered αSyn clearance in primary neurons.
    [npj Parkinson’s Disease]

    Full Article

    A Custom-Made AAV1 Variant (AAV1-T593K) Enables Efficient Transduction of Japanese Quail Neurons In Vitro and In Vivo

    Scientists presented a unique culturing method, transcriptomic profiles of quail’s brain cells, and a custom-tailored AAV1 for the transduction of quail neurons in vitro and in vivo.
    [Communications Biology]

    Full Article

    Glioma Cells Expressing High Levels of ALDH5A1 Exhibit Enhanced Migration Transcriptional Signature in Patient Tumors

    Investigators showed that succinic semialdehyde dehydrogenase (SSADH) was upregulated in glioma tissues irrespective of the histological grade and its expression sustains glioma cell motility.
    [Neurotherapeutics]

    Abstract

    Chrysophanol Exerts a Protective Effect against Aβ25-35-Induced Alzheimer’s Disease Model through Regulating the ROS/TXNIP/NLRP3 Pathway

    Researchers focused on the ROS/TXNIP/NLRP3 pathway to determine whether chrysophanol regulates oxidative stress and neuroinflammation.
    [Inflammopharmacology]

    Abstract
    Virtual Poster Presentation: CRISPR-Cas9 Gene Editing of Cerebral Organoids to Model Microcephaly
    REVIEWS

    The Role of Astrocytic α7 Nicotinic Acetylcholine Receptors in Alzheimer Disease

    Investigators discuss the involvement of astrocytic α7nAChRs in the instigation and potentiation of early amyloid-β pathology and explore their potential as a target for future reactive astrocyte-based therapeutics and imaging biomarkers in Alzheimer’s disease.
    [Nature Reviews Neurology]

    Abstract

    Lost in Local Translation: TDP-43 and FUS in Axonal/Neuromuscular Junction Maintenance and Dysregulation in Amyotrophic Lateral Sclerosis

    The authors cover recent discoveries on axonal translation as a critical mechanism for neuronal maintenance and survival. They focus on two RNA-binding proteins whose mutations cause amyotrophic lateral sclerosis and frontotemporal dementia.
    [Neuron]

    Abstract
    INDUSTRY AND POLICY NEWS

    Cyclerion Therapeutics Receives US FDA Orphan Drug Designation for Zagociguat for the Treatment of Mitochondrial Diseases

    Cyclerion Therapeutics, Inc. announced that the US FDA has granted orphan drug designation to zagociguat for the treatment of mitochondrial diseases.
    [Cycleroin Therpeutics, Inc.]

    Press Release
    FEATURED EVENT

    3D Cell Culture 2023: Models, Applications & Translation

    April 17 – 19, 2023
    Freiburg im Breisgau, Germany

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Digital Optical Neural Networks

    Technical University of Denmark – Kongens Lyngby, Denmark

    Postdoctoral Position – Cognitive Neuroscience

    University of Amsterdam – Amsterdam, Netherlands

    Associate Research Scientists – Cancer Genetics

    Columbia University – New York City, New York, United States

    Staff Scientist – Pediatric Brain Tumors

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Fellow – Cancer and Neurodegenerative Diseases

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    > See All Jobs

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