Neural Cell News Volume 17.13 | Apr 05 2023

April 5, 2023

2023-04-05 | NCN 17.13

Neural Cell News by STEMCELL Technologies

Vol. 17.13 – 5 April, 2023

TOP STORY

Generation and Multi-Dimensional Profiling of a Childhood Cancer Cell Line Atlas Defines New Therapeutic Opportunities

Scientists
established a single-site collection of 261 cell lines, including 224 pediatric cell lines representing 18 distinct extracranial and brain childhood tumor types.
[Cancer Cell]

Abstract Graphical Abstract

Her 'mini-brains' creation was unexpected. Her protocol was groundbreaking. Watch Madeline Lancaster's webinar.

PUBLICATIONSRanked by the impact factor of the journal

Rewired m⁶A Epitranscriptomic Networks Link Mutant p53 to Neoplastic Transformation

Researchers investigated Li-Fraumeni syndrome-associated neoplastic transformation driven by mutant p53 in induced pluripotent stem cell-derived astrocytes, the cell-of-origin of gliomas.
[Nature Communications]

Full Article

A Sensory Neuron-Specific Long Noncoding RNA Reduces Neuropathic Pain by Rescuing KCNN1 Expression

Scientists reported a novel lncRNA, named sensory neuron-specific lncRNA, for its expression exclusively in the dorsal root ganglion and trigeminal ganglion.
[Brain]

Abstract

Brain p3-Alcβ Peptide Restores Neuronal Viability Impaired by Alzheimer’s Amyloid β-Peptide

Investigators found that p3-Alcβ37 and its shorter peptide p3-Alcβ9-19 enhanced the mitochondrial activity of neurons and protected neurons against Aβo-induced toxicity.
[EMBO Molecular Medicine]

Full Article Graphical Abstract

Molecules of Senescent Glial Cells Differentiate Alzheimer’s Disease from Aging

Researchers identified the biomarkers in the cerebrospinal fluid that could help differentiate healthy aging from neurodegenerative processes.
[Journal Of Neurology, Neurosurgery & Psychiatry]

Abstract

Development of a Synthetic, Injectable Hydrogel to Capture Residual Glioblastoma and Glioblastoma Stem-like Cells with CXCL12-mediated Chemotaxis

Investigators developed a thiol-Michael addition injectable hydrogel further to capture glioblastoma/glioblastoma stem-like cells through CXCL12-mediated chemotaxis.
[Advanced Healthcare Materials]

Abstract

Astrocytes Express Aberrant Immunoglobulins as Putative Gatekeeper of Astrocytes to Neuronal Progenitor Conversion

To understand whether a complete mechanism involving antibody production also occurs in astrocytes like in B cells, researchers investigated by pan-transcriptomic, and proteomic the complete repertoire of IgG chains.
[Cell Death & Disease]

Full Article

Bif-1c Attenuates Viral Proliferation by Regulating Autophagic Flux Blockade Induced by the Rabies Virus CVS-11 Strain in N2a Cells

Investigators showed that bax-interacting factor-1 (Bif-1) colocalized with LC3 and partially alleviated the incomplete autophagic flux induced by rabies virus.
[Microbiology Spectrum]

Full Article

Small Extracellular Vesicles Promote Invadopodia Activity in Glioblastoma Cells in a Therapy-Dependent Manner

Researchers found that small extracellular vesicles secreted by glioblastoma cells can facilitate tumor invasion by promoting invadopodia activity in recipient cells, which may be enhanced by treatment with radio-chemotherapy.
[Cellular Oncology]

Full Article

Scientific resources to support your organoids research. Learn More!

REVIEWS

An Aging, Pathology Burden, and Glial Senescence Build-Up Hypothesis for Late Onset Alzheimer’s Disease

The authors hypothesize that aging first drives Alzheimer’s disease (AD) pathology burden, whereafter AD pathology putatively induces glial senescence in late onset .
[Nature Communications]

Full Article

Exosome-Based Nanoimmunotherapy Targeting TAMs, a Promising Strategy for Glioma

Investigators review the current potential exosome-mediated immunotherapeutics targeting tumor-associated macrophages (TAMs) in glioma and conclude the recent investigation on the fundamental mechanisms of diversiform molecular signaling events by TAMs that promote glioma progression.
[Cell Death & Disease]

Full Article

INDUSTRY AND POLICY NEWS

BrainStorm Finds Path through FDA Regulatory Jungle for Twice-Dismissed ALS Drug

BrainStorm Cell Therapeutics has been determined to get a twice-rejected ALS treatment through the FDA process.
[Fierce Biotech]

Press Release

FEATURED EVENT

Neural Cell News Volume 17.13 | Apr 05 2023

Generation and Multi-Dimensional Profiling of a Childhood Cancer Cell Line Atlas Defines New Therapeutic Opportunities

Rewired m⁶A Epitranscriptomic Networks Link Mutant p53 to Neoplastic Transformation

A Sensory Neuron-Specific Long Noncoding RNA Reduces Neuropathic Pain by Rescuing KCNN1 Expression

Brain p3-Alcβ Peptide Restores Neuronal Viability Impaired by Alzheimer’s Amyloid β-Peptide

Molecules of Senescent Glial Cells Differentiate Alzheimer’s Disease from Aging

Development of a Synthetic, Injectable Hydrogel to Capture Residual Glioblastoma and Glioblastoma Stem-like Cells with CXCL12-mediated Chemotaxis

Astrocytes Express Aberrant Immunoglobulins as Putative Gatekeeper of Astrocytes to Neuronal Progenitor Conversion

Bif-1c Attenuates Viral Proliferation by Regulating Autophagic Flux Blockade Induced by the Rabies Virus CVS-11 Strain in N2a Cells

Small Extracellular Vesicles Promote Invadopodia Activity in Glioblastoma Cells in a Therapy-Dependent Manner

An Aging, Pathology Burden, and Glial Senescence Build-Up Hypothesis for Late Onset Alzheimer’s Disease

Exosome-Based Nanoimmunotherapy Targeting TAMs, a Promising Strategy for Glioma

BrainStorm Finds Path through FDA Regulatory Jungle for Twice-Dismissed ALS Drug

75^th AAN Annual Meeting

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Postdoctoral Position – Sensory Neuroscience

Postdoctoral Scholar – Immunotherapy for Glioblastoma

Research Fellow – Neuromuscular Disease

Postdoctoral Research Scientist – Neuroimmune Organoids in Neurodegeneration

Postdoctoral Fellow – Tumor Suppressor p53

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