 | | Vol. 17.14 – 12 April, 2023 |
| |
|
|
| The clustered protocadherin gamma 3 isoform mediated homophilic interactions between sensory axons and spinal cord neurons to promote synapse formation in vivo and was sufficient to induce postsynaptic specializations in vitro.
[Neuron] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists measured transcription rate and mRNA half-life changes in Rett syndrome patient neurons using RATEseq, and re-interpreted nuclear and whole-cell RNAseq from methyl CpG-binding protein 2 (Mecp2) mice.
[Nature Communications] |
|
|
|
| Researchers employed global proteomic and single-cell genomic approaches in stable cell lines as well as induced pluripotent stem cell-derived neurons and midbrain organoids to dissect the mechanisms underlying β-glucocerebrosidase-related neurodegeneration.
[Nature Communications] |
|
|
|
| The authors used a connectomic approach using a high-resolution, serial-sectioning scanning electron microscopy volume to investigate the laminar cytoarchitecture of the transient external granular layer of the developing cerebellum, where granule cells coordinate a series of mitotic and migratory events.
[Science Advances] |
|
|
|
| Investigators found that connexin-43 (Cx43) was highly expressed by subventricular zone neural stem cells (NSC) and endothelial cells (EC), and its deletion in either led to increased NSC proliferation and neuroblast generation, suggesting that Cx43-mediated NSC-EC interactions maintained NSC quiescence.
[Cell Reports] |
|
|
|
| Using translating ribosome affinity purification with sequencing tools, researchers simultaneously decoded the transcriptomes of graft and host for human neural stem cells transplanted into the stroke-injured rat brain.
[Cell Reports] |
|
|
|
| Scientists showed that ectopic neural stem cells induced via basic helix–loop–helix transcription factor Deadpan expression failed to undergo appropriate temporal progression by constantly expressing mid-temporal transcription factor, Sloppy-paired 1/2.
[EMBO Reports] |
|
|
|
| Insulin-like growth factor binding protein-3, IGFBP3, knockdown inhibited the activation of transforming growth factor-β (TGF-β) and epidermal growth factor receptor variant III (EGFRvIII) signals and the malignant behaviors triggered by them in vitro and in vivo.
[iScience] |
|
|
|
| An in vitro model of the human blood-brain barrier was developed, based on a collagen hydrogel containing astrocytes, overlaid with a monolayer of endothelium, differentiated from human induced pluripotent stem cells.
[PLOS One] |
|  |
|
|
|
| Scientists dive into the multifaceted biological domains implicated to date in Alzheimer’s Disease risk, highlighting studies of the diverse genetic drivers of disease, and more.
[Trends In Neurosciences] |
|
|
|
| The authors review recent research using CNS-originating extracellular vesicles (EVs) for biomarker studies, primarily in parkinsonian disorders, highlight technical challenges, and propose strategies for overcoming them.
[Acta Neuropathologica] |
|
|
|
| Scientists review normal synaptic development and evidence from structural and functional imaging and post-mortem studies that this is abnormal in people at risk and with schizophrenia. They then consider the mechanism that could underlie synaptic changes and update the hypothesis.
[Molecular Psychiatry] |
|
|
|
|
| Combining experiments and theory, the funded project “Decoding the gelatinous origins of brain evolution”, aims to understand the computations of the very simple nervous system of the marine organism ctenophore Mnemopsis leidyi, also known as the sea walnut.
[The University of Bergen] |
|
|
|
|
| April 26 – 28, 2023
Singapore, Singapore |
|
|
|
|
|
| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
|
|
|
| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
|
|
|
| | University of Oklahoma – Oklahoma City, Oklahoma, United States |
|
|
|
| | National Institute of Health – Bethesda, Maryland, United States |
|
|
|
| | VIB-UAntwerp Center of Molecular Neurology – Antwerp, Belgium |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
