Neural Cell News Volume 17.15 | Apr 19 2023

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    Jamie Kang
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    2023-04-19 | NCN 17.15


    Neural Cell News by STEMCELL Technologies
    Vol. 17.15 – 19 April, 2023
    TOP STORY

    The Nature of Prefrontal Cortical GABA Neuron Alterations in Schizophrenia: Markedly Lower Somatostatin and Parvalbumin Gene Expression without Missing Neurons

    To identify somatostatin and parvalbumin neurons in postmortem human dorsolateral prefrontal cortex, the authors used fluorescent in situ hybridization to label cells expressing two transcripts not altered in schizophrenia: vesicular GABA transporter and SOX6.
    [American Journal Of Psychiatry]

    Abstract
    Survey results on the needs and challenges in the human pluripotent stem cell field
    PUBLICATIONSRanked by the impact factor of the journal

    Low Glucose Induced Alzheimer’s Disease-Like Biochemical Changes in Human Induced Pluripotent Stem Cell-Derived Neurons Is Due to Dysregulated O-GlcNAcylation

    Investigators revealed that dysregulated O-GlcNAc, in part through mitochondrial dysfunction, caused the onset of sporadic Alzheimer’s disease (sAD)-like changes. They demonstrated the therapeutic potential of inhibiting O-GlcNAcase in alleviating AD-like biochemical changes.
    [Alzheimers & Dementia]

    Full Article

    Stalled Oligodendrocyte Differentiation in IDH-Mutant Gliomas

    Scientists showed that despite differences in clinical manifestation and genomic alterations, all isocitrate dehydrogenase (IDH)-mutant gliomas resembled early stages of oligodendrocyte lineage and are stalled in oligodendrocyte differentiation due to blocked myelination program.
    [Genome Medicine]

    Full Article

    Upregulation of KLK8 Contributes to CUMS-Induced Hippocampal Neuronal Apoptosis by Cleaving NCAM1

    Researchers explored the potential function of tissue kallikrein-related peptidase 8 (KLK8) in hippocampal neuronal cell apoptosis associated with depressive disorders in rodent models of chronic unpredictable mild stress (CUMS)-induced depression.
    [Cell Death & Disease]

    Full Article

    Dedifferentiation-Derived Neural Stem Cells Exhibit Perturbed Temporal Progression

    Scientists showed that ectopic NSCs induced via bHLH transcription factor Deadpan expression failed to undergo appropriate temporal progression by constantly expressing mid-temporal transcription factor, Sloppy-paired 1/2.
    [EMBO Reports]

    Full ArticleGraphical Abstract

    Scalable Generation of Sensory Neurons from Human Pluripotent Stem Cells

    Following principles of developmental biology and translational applicability, investigators developed an efficient stepwise differentiation method for peptidergic and non-peptidergic nociceptors.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Neuronopathic Gaucher Disease Models Reveal Defects in Cell Growth Promoted by Hippo Pathway Activation

    Using a combination of Drosophila dGBA1b loss-of-function models and Gaucher disease (GD) patient-derived induced pluripotent stem cells, researchers showed that different GD tissues and neuronal cells displayed an impairment of growth mechanisms with increased cell death and reduced proliferation.
    [Communications Biology]

    Full Article

    Spike-Timing-Dependent Plasticity Alters Electrosensory Neuron Synaptic Strength In Vitro, but Does Not Consistently Predict Changes in Sensory Tuning In Vivo

    Using whole-cell intracellular recordings in awake, behaving fish, scientists paired sensory stimulation with postsynaptic spiking using the same delays. They found that Hebbian spike-timing-dependent plasticity predictably altered sensory tuning in vitro and is mediated by NMDA receptors.
    [Journal Of Nephrology]

    Abstract

    Connexin 43 Promotes Neurogenesis via Regulating Aquaporin-4 after Cerebral Ischemia

    Investigators tested the effects of connexin43 (Cx43) on ischemic neurogenesis and examined whether it was dependent on aquaporin-4 (AQP4). They detected the expression of Cx43 and AQP4 in the ipsilateral subventricular zone and peri-infarct cortex after middle cerebral artery occlusion.
    [Neurotoxicity Research]

    Abstract
    Webinar: The Promise of Organoid Medicine
    REVIEWS

    Cancer Neuroscience: State of the Field, Emerging Directions

    The authors identify important unanswered questions and current roadblocks in cancer neuroscience, specifying ways to overcome these obstacles through the implementation of cross-disciplinary development of technologies, knowledge, and scholarly infrastructure.
    [Cell]

    Full Article

    “Sentinel or Accomplice” — Gut Microbiota and Microglia Cross-Talk in Disorders of Gut-Brain Interaction

    Scientists focus on the role and underlying mechanism of the interaction between gut microbiota and microglia in disorders of gut-brain interaction, especially irritable bowel syndrome, and highlight its potential to treat disorders of gut-brain interaction in individuals with psychiatric comorbidities.
    [Protein & Cell]

    Abstract

    Graphical Abstract
    INDUSTRY AND POLICY NEWS

    US Could Soon Approve MDMA Therapy — Opening an Era of Psychedelic Medicine

    Perceptions have shifted dramatically in the past few years on the therapeutic value of illicit drugs such as ecstasy. But questions still linger about what FDA approval might look like.
    [Nature]

    Press Release

    8.8 Million Euros for Accelerated Drug Repurposing for Rare Neurological Disorders

    The SIMPATHIC Consortium, led by the Radboud University Medical Center and Amsterdam UMC, has developed a new approach to expedite the use of existing drugs for groups of patients with rare neurological disorders.
    [Amsterdam UMC]

    Press Release

    NIH-Funded Research Could Lead to New Drug Treatments for Alzheimer’s Disease

    Assistant Professor Jole Fiorito, Ph.D., who specializes in medicinal chemistry, secured a three-year grant from the National Institutes of Health (NIH) National Institute of Neurological Disorders and Stroke. The $438,583 grant will support research into early-stage drug development to treat Alzheimer’s disease.
    [New York Tech]

    Press Release
    FEATURED EVENT

    Cell Culture Engineering XVIII

    April 23 – 28, 2023
    Cancun, Mexico

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    JOB OPPORTUNITIES

    Postdoctoral Position – Neural-Immune Interaction

    National Institutes of Health – Bethesda, Maryland, United States

    Faculty Positions – Cancer Research

    Case Western Reserve University – Cleveland, Ohio, United States

    Postdoctoral Research Associate – Head and Neck Cancer

    University of Liverpool – Liverpool, England, United Kingdom

    Specialist – StainsFile

    STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada

    Faculty Positions – Neuro-Oncology and Neurovascular Research

    University of Alabama at Birmingham – Birmingham, Alabama, United States

    > See All Jobs

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