 | | Vol. 17.16 – 26 April, 2023 |
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| Investigators reported that activation of cyclic GMP–AMP synthase (cGAS) diminished cognitive resilience by decreasing the neuronal transcriptional network of myocyte enhancer factor 2c (MEF2C) through type I interferon (IFN-I) signaling.
[Nature Neuroscience] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that miR-483-5p in the amygdala of male mice counterbalances the structural, functional and behavioral consequences of stress to promote a reduction in anxiety-like behavior.
[Nature Communications] |
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| Investigators found the activity of the transcriptional co-activator Yap1 to be enriched in active neural stem cells (NSCs). Genetic deletion of Yap1 led to a significant reduction in the relative proportion of active NSCs, supporting the physiological role of Yap1 in regulating the transition from quiescence to activation.
[EMBO Journal] |
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| Scientists comprehensively evaluated the significance of a novel invasion-related protein, Family with Sequence Similarity 129 Member A (FAM129A), in infiltrative glioma stem cells.
[Neuro-Oncology] |
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| Investigators uncovered a unique function of octopamine in the mammalian brain as a key metabolite diving the switch from protective to toxic astrocytes by harnessing their metabolism toward aerobic glycolysis
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists described a novel neuro-mesodermal assembloid model that recapitulated aspects of peripheral nervous system development such as neural crest cell induction, migration, and sensory as well as sympathetic ganglion formation.
[Stem Cell Reports] |
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| Researchers investigated Alzheimer’s disease (AD) mediated endothelial cell activation by studying the effect of amyloid beta peptides secreted from human-induced pluripotent stem cell-derived cortical neurons harboring a familial AD mutation on human brain microvascular endothelial cells in perfusable microvessels.
[Neurobiology Of Disease] |
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| Scientists identified gene-expression changes in induced pluripotent stem cells (iPSCs) and iPSC-derived neural stem cells (NSCs) from a patient with globoid cell leukodystrophy (GLD) and normal control, in order to investigate the potential mechanism underlying GLD pathogenesis.
[BMC Genomics] |
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| Researchers assessed the membrane topographical and structural effects of PM2.5 from incense PM2.5 exposure in real time on A549 lung carcinoma epithelial cells and SH-SY5Y neuroblastoma cells that had been fixed to preclude adaptive cell responses.
[Analytical And Bioanalytical Chemistry] |
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| The authors focus on the association between the brain-based paravascular drainage pathway known as the “glymphatic system” and traumatic brain injury-related neurodegeneration.
[Molecular Psychiatry] |
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| The US FDA will require new safety warnings to be added to labels for opioid pain relievers, including a warning about increased sensitivity to pain. Data suggests patients who use opioids for pain relief after surgery often have leftover tablets, which puts them at risk for addiction and overdose.
[Reuters] |
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| | University of California, San Diego – La Jolla, California, United States |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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| | University of Liverpool – Liverpool, England, United Kingdom |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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