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| Scientists investigated the concept of leveraging metabolism-targeting interventions as an indirect means of modulating MYC abundance and activity in group 3 medulloblastoma.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that acyl-CoA binding protein downregulation results in wide transcriptional changes affecting invasion-related genes.
[Cell Death & Disease] |
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| Scientists employed neural stem cells (NSCs) derived from human-induced pluripotent stem cells together with exosomes extracted from NSCs to treat cerebral ischemia induced by middle cerebral artery occlusion/reperfusion in mice.
[eLife] |
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| Researchers studied genome-wide gene expression profiles of differentiated neural progenitor cells from wild-type and APPswe/PS1dE9 mouse embryo telencephalon.
[Stem Cell Reviews And Reports] |
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| Investigators presented a co-culture model of neurons and microglia, both of human origin, to show increased susceptibility of neurons to microglia-like cells derived from schizophrenia spectrum patients.
[Communications Biology] |
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| Scientists designed a 3D in vitro model of the perivascular niche comprising either collagen Type 1 or HyStem-C, human umbilical vein endothelial cells, and LN229 cells.
[ACS Biomaterials Science & Engineering] |
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| Researchers investigated the effect of N,N-dimethylacetamide on neuroinflammation and its mechanism of action in in vitro and ex vivo models of Alzheimer’s disease.
[Scientific Reports] |
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| Investigators found that M. fermentans could infect and replicate in human neuronal cells, inducing necrotic cell death.
[Scientific Reports] |
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| Scientists demonstrated that posttreatment with ospemifene in primary neocortical cell cultures subjected to 18 h of hypoxia and/or ischemia followed by 6 h of reoxygenation had robust neuroprotective potential.
[Neurotoxicity Research] |
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| Advances in novel therapies provide some promise for people with glioblastoma; however, the effects of these therapies on seizures are yet to be fully determined. Insights into electrical activity as a driver of tumor cell growth may present useful targets for treatment and disease modification.
[Lancet Neurology] |
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| Erasca, Inc. announced the US FDA granted Fast Track Designation to ERAS-801 for the treatment of adult patients with glioblastoma with epidermal growth factor receptor (EGFR) gene alterations.
[Erasca, Inc.] |
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| May 17 – 19, 2023
Hinxton, England, United Kingdom |
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| | Karolinska Institutet – Solna, Sweden |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | University of California, San Diego – La Jolla, California, United States |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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