 | | Vol. 17.18 – 10 May, 2023 |
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| Researchers sought to determine how glioma-induced neuronal changes influence neural circuits underlying cognition and whether these interactions influence patient survival.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that cancer-activated astrocytes created a sustained low-level activated type I interferon (IFN) microenvironment in brain metastatic lesions. They further confirmed that the IFN response in astrocytes facilitated brain metastasis.
[Nature Communications] |
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| Investigators hypothesized that histone deacetylase inhibitors induced the neuronal differentiation of SH-SY5Y cells. They used phase contrast microscopy, immunocytochemistry, qPCR, and western blotting analysis to confirm.
[BMC Neuroscience] |
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| Scientists presented the potential of neural stem cells as drug delivery systems for nucleoside analogue-conjugated nanogels (NGs). Two different approaches were investigated: the intracellular loading and extracellular cell surface decoration with NGs.
[ACS Applied Materials & Interfaces] |
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| Investigators utilized human cytomegalovirus-infected induced pluripotent stem cells to generate in vitro brain organoids, modeling the first trimester of fetal brain development.
[Journal Of Virology] |
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| Researchers generated multiplexed protein maps over a retinal organoid time course and primary adult human retinal tissue. They also generated a single-cell transcriptome and chromatin accessibility timecourse dataset and inferred a gene regulatory network underlying organoid development.
[Nature Biotechnology] |
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| Scientists showed that insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) binds MYCN mRNA with N6-methyladenosine modification and regulates its stability and expression. This in turn, can bind to the IGF2BP3 promoter to promote its expression.
[Cell Death Discovery] |
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| Researchers presented the first experimental evidence for human cytomegalovirus as a reprogramming vector, straight through the dedifferentiation of mature human astrocytes, and generation of cytomegavirus–elicited glioblastoma cells possessing glioblastoma-like traits.
[Oncogene] |
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| Investigators studied the anti-inflammatory effects of the compound cannabidiol (CBD) in comparison with Δ (9)-tetrahydrocannabinol in human microglial cells infected with human immunodeficiency virus.
[Scientific Reports] |
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The authors review the involvement of the gut–brain axis in the development and progression of Parkinson’s disease from the perspective of the gut microbiota.
[npj Parkinson’s Disease] |
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| The grant will fund an innovative project by Dr. Maria MacDonald of the London Health Sciences Centre and Drs. Julie Bennett and Cynthia Hawkins of the Hospital for Sick Children. They are working to identify the proportion of adults with brain tumors with a genetic profile typically seen in children.
[Brain Cancer Canada] |
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| Plus Therapeutics, Inc. announced an expansion of its collaboration with Piramal Pharma Solutions to produce additional cGMP liposome intermediate drug product to meet the increase in demand for its lead investigational targeted radiotherapeutic, rhenium obisbemeda, for ongoing and planned clinical trials.
[Plus Therapeutics, Inc.] |
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| May 23 – 25, 2023
Bar Harbor, Maine, United States & Virtual |
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| | The National University of Singapore – Singapore, Singapore |
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| | Karolinska Institutet – Solna, Sweden |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | University of California, San Diego – La Jolla, California, United States |
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