 | | Vol. 17.19 – 17 May, 2023 |
| |
|
|
| Researchers showed that melanin-concentrating hormone (MCH) downregulated synaptic transmission, modulated firing rate homeostasis in hippocampal neurons, and reversed the increased excitatory drive to CA1 neurons in AppNL-G-F mice.
[Nature Neuroscience] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators showed that mitochondria transfer is a prevalent phenomenon in glioblastoma (GBM). They identified horizontal mitochondria transfer from astrocytes as a mechanism that enhanced tumorigenesis in GBM.
[Nature Cancer] |
|
|
|
| Scientists established the clinical utility of serial circulating tumor DNA sampling to track response and progression, and discovered acquired resistance mechanisms that could be leveraged to develop therapeutic strategies to overcome lorlatinib resistance.
[Nature Communications] |
|
|
|
| Investigators found that the expression of tripartite motif-containing 25 (TRIM 25) was upregulated in glioblastoma multiforme (GBM), and was associated with tumor grade and temozolomide resistance. Elevated TRIM25 expression predicted a poor prognosis in GBM patients and enhanced tumor growth.
[Oncogene] |
|
|
|
| Researchers constructed a mouse cortical neuron oxygen glucose deprivation/reoxygenation (OGD/R) model and demonstrated that N1-methyladenosine modification was abundant in neuron mRNAs and dynamically regulated during OGD/R induction.
[Cell Death Discovery] |
|
|
|
| Scientists performed comprehensive analyses of Bloom helicase (BLM) expression and functions in glioblastmas and demonstrated high levels of the BLM mRNA and protein in malignant tumors and glioma cell lines, along with abnormal cytoplasmic accumulation of BLM in GBMs.
[Cell Death Discovery] |
|
|
|
| Researchers first generated human cortical organoids from a single rosette to create more homogenous organoids. They then took advantage of a 3D co-culture system to encapsulate brain organoids with a thin layer of meningeal cells from the very early stages of cortical development.
[Scientific Reports] |
|
|
|
| Investigators analyzed the contribution of syntaphilin and Armadillo repeat-containing X-linked protein 1 to the neuronal damage resulting from intracerebral hemorrhage (ICH). Primary cultured neuron cells were exposed to oxygenated hemoglobin to replicate the effects of ICH stimulation.
[Neuroscience Letters] |
|
|
|
| Scientists investigated the role of oligodendroglia in sporadic amyotrophic lateral sclerosis (SALS) pathophysiology using a human oligodendroglial cell line, MO3.13, by exposing the cells to cerebrospinal fluid from SALS patients.
[Molecular Neurobiology] |
|
|
|
|
| The authors highlight latest findings related to cytokines in the central nervous system and their regulation of synapse structure and function. They also explore how these mechanisms are becoming increasingly important to consider in diseases — especially those with a large neuroinflammatory component.
[Immunity] |
|
|
|
|
| Brain Cancer Canada has awarded a CAD 80,000 research grant to Dr. Sheila Singh and her team at McMaster University. This grant supports their pioneering work on developing a new therapeutic approach for glioblastoma.
[Brain Cancer Canada (Globe Newswire)] |
|
|
|
|
| May 28 – 31, 2023
Killarney, Ireland |
|
|
|
|
|
| | National Institutes of Health – Bethesda, Maryland, United States |
|
|
|
| | Center for Disease Neurogenomics at the Icahn School of Medicine – Manhattan, New York, United States |
|
|
|
| | The National University of Singapore – Singapore, Singapore |
|
|
|
| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
|
|
|
| | National Institutes of Health – Bethesda, Maryland, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
