Neural Cell News Volume 17.20 | May 24 2023

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    Jamie Kang
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    2023-05-24 | NCN 17.20


    Neural Cell News by STEMCELL Technologies
    Vol. 17.20 – 24 May, 2023
    TOP STORY

    iPSC-Derived Reactive Astrocytes from Patients With Multiple-Sclerosis Protect Cocultured Neurons in Inflammatory Conditions

    Researchers generated induced pluripotent stem cells (iPSCs) to investigate possible mechanisms in benign MS, compared to progressive MS. They differentiated neurons and astrocytes that were then stressed with inflammatory cytokines typically associated with MS.
    [Journal Of Clinical Investigation]

    AbstractGraphical Abstract
    An ISSCR 2022 COREdinates Webinar: Differentiation of High-Quality hPSCs Using STEMdiff â„¢ and TeSR â„¢-AOF, presented by Kim Snyder. Click to Watch Now.
    PUBLICATIONSRanked by the impact factor of the journal

    Galectin-3 Shapes Toxic Alpha-Synuclein Strains in Parkinson’s Disease

    In vitro studies demonstrated that exogenous recombinant galectin-3 was internalized by neuronal cell lines and primary neurons where it interacted with endogenous α-synuclein fibrils.
    [Acta Neuropathologica]

    Full Article

    PP2Ac Deficiency Enhances Tumor Immunogenicity by Activating STING-Type I Interferon Signaling in Glioblastoma

    Scientists demonstrated a fundamental role for the α-isoform of the catalytic subunit of protein phosphatase-2A (PP2Ac) in regulating glioma immunogenicity. In co-culture experiments, PP2Ac deficiency in glioma cells promoted dendritic cell cross presentation and clonal expansion of CD8+ T cells.
    [Cancer Research]

    Abstract

    Neurofilament Accumulations in Amyotrophic Lateral Sclerosis Patients’ Motor Neurons Impair Axonal Initial Segment Integrity

    To assess neurofilament accumulations and study the impact on motor neurons (MNs), investigators compared MNs derived from induced pluripotent stem cells of patients carrying mutations in C9orf72, SOD1, and TARDBP genes, the three main ALS genetic causes.
    [Cellular And Molecular Life Sciences]

    Full Article

    Cannabidiol Protects Dopaminergic-Like Neurons Against Paraquat- and Maneb-Induced Cell Death Through Safeguarding DJ-1CYS106 and Caspase 3 Independently of Cannabinoid Receptors: Relevance in Parkinson’s Disease

    Menstrual stromal cell-derived dopamine-like neurons intoxicated with paraquat/maneb were used as a model system to elucidate the mechanism by which cannabidiol protected the neural cell from apoptosis in vitro.
    [ACS Chemical Neuroscience]

    AbstractGraphical Abstract

    3D Bioprinting Patient-Derived Induced Pluripotent Stem Cell Models of Alzheimer’s Disease Using a Smart Bioink

    The combination of cells, bioink, and puromorphamine-releasing microspheres were used to mimic the in vivo environment and direct the differentiation of the neural progenitor cells into basal forebrain-resembling cholinergic neurons.
    [Bioelectronic Medicine]

    Full Article

    AZD5438 a GSK-3a/b and CDK Inhibitor Is Antiapoptotic Modulates Mitochondrial Activity and Protects Human Neurons from Mitochondrial Toxins

    Experiments in human-induced pluripotent stem cell-derived cortical and midbrain neurons showed AZD5438 mediated significant protective effects, preventing neuronal cell death, and collapse in the neurite and mitochondrial network associated with rotenone treatment.
    [Scientific Reports]

    Full Article

    Sting and p53 DNA Repair Pathways are Compromised in Alzheimer’s Disease

    Scientists reported that the monomer:dimer ratio of phosphorylated p53 increased by 2.86-fold in the temporal lobes of Alzheimer’s disease (AD) patients compared to age-matched controls, indicating that p53 oligomerization was compromised in AD.
    [Scientific Reports]

    Full Article
    Survey results on the needs and challenges in the human pluripotent stem cell field
    REVIEWS

    Common Signaling Pathways Involved in Alzheimer’s Disease and Stroke: Two Faces of the Same Coin

    The authors summarize the most common signaling cascades including autotoxicity, ApoE4, insulin signaling, inflammation, mTOR-autophagy, notch signaling, and microbiota-gut-brain axis, present in both Alzheimer’s disease and ischemic stroke.
    [Journal Of Alzheimers Disease]

    Full Article

    Genetically Engineered Neural Stem Cells (NSCs) Therapy for Neurological Diseases; State-of-the-Art

    Investigators review the therapeutic capability of genetically modified NSCs rather than naïve NSCs in neurological disease beyond brain tumors and shed light on the recent progress and prospect in this context.
    [Biotechnology Progress]

    Abstract
    INDUSTRY AND POLICY NEWS

    vTv Therapeutics Announces Issuance of US Patent for Azeliragon as a Treatment of Glioblastoma to Cantex Pharmaceuticals

    vTv Therapeutics, Inc. announced that the US Patent and Trademark Office recently issued a patent to Cantex Pharmaceuticals, Inc. that covers claims related to the use of azeliragon as a potential treatment of glioblastoma multiforme.
    [vTv Therapeutics, Inc.]

    Press Release
    FEATURED EVENT

    The 2023 ASCO Annual Meeting

    June 2 – 6, 2023
    Chicago, Illinois, United States

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    JOB OPPORTUNITIES

    Senior Research Associate – iPSC to Model Neurodegenerative Diseases

    Recursion Pharmaceuticals – Salt Lake City, Utah, United States

    Postdoctoral Intramural Research Fellowship Position – Orthobunyaviruses

    National Institute of Allergy and Infectious Diseases – Hamilton, Montana, United States

    Postdoctoral Research Scientist – Neuroimmune Organoids in Neurogeneration

    University of Antwerp – Antwerp, Belgium

    Postdoctoral Fellow – Neural-Immune Interactions

    National Institutes of Health – Bethesda, Maryland, United States

    Assistant/Associate Professor – Genome Editing and Therapeutics

    Center for Disease Neurogenomics at the Icahn School of Medicine – Manhattan, New York, United States

    > See All Jobs

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