 | | Vol. 17.21 – 31 May, 2023 |
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| Researchers reported how the recently discovered brain and dorsal root ganglia-expressed fatty acid amide hydrolase (FAAH)-OUT long non-coding RNA gene regulated the adjacent key endocannabinoid system gene FAAH, which encoded the anandamide-degrading FAAH enzyme.
[Brain] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists cultured human cerebral organoids derived from human pluripotent stem cells and transplanted them into the junction of the infarct core and the peri-infarct zone of non-obese diabetes-severe combined immunodeficiency (NOD-SCID) mice subjected to stroke.
[NPJ Regenerative Medicine] |
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| Researchers determined a critical drug that caused ferroptosis in glioblastoma cells and elucidated the possible mechanism by which drug combinations overcame chemoresistance.
[Clinical Cancer Research] |
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| Scientists demonstrated the in vitro and in vivo production of myelinating oligodendrocytes from a human-induced pluripotent stem cell-derived long-term neuroepithelial stem cell line, which also gave rise to neurons with the capacity to integrate into stroke-injured, adult rat cortical networks.
[Stem Cell Reports] |
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| Investigators showed that lead treatment significantly downregulated triggering receptor expressed on myeloid cells 2 (TREM2) expression and altered the localization of TREM2 expression in microglia.
[Ecotoxicology And Environmental Safety] |
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| Researchers investigated the role and molecular mechanism of tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) using a lipopolysaccharide-induced inflammatory injury model in BV2 cells.
[International Immunopharmacology] |
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| Scientists reported a trophic, tumor-promoting role of P2X7R activation in both patient-derived primary glioblastoma cultures and the U251 human glioblastoma cell line, and demonstrated its inhibition reduced tumor growth in vitro.
[Scientific Reports] |
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| Investigators studied the potential role and molecular mechanism of the combination therapy of B7H6-siRNA and temozolomide in glioblastoma cancer.
[Experimental Cell Research] |
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| Using immortalized HT22 mouse hippocampal neuronal cells as a model, scientists showed that nitric oxide accumulation via protein disulfide isomerase-mediated neuronal nitric oxide synthase activation plays a critical role in chemically-induced ferroptosis.
[Acta Biochimica Et Biophysica Sinica] |
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| The authors compare brain tumor organoids (BTO) with common models including cell lines, tumor spheroids, and patient-derived xenografts. They conclude BTOs could be a reliable model to understand brain tumors and develop targeted therapies.
[CNS Neuroscience & Therapeutics] |
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| By merging with a blank check company, Anew Medical plans to land a Nasdaq listing and $54 million in cash to fund the development of its neurodegenerative disease gene therapies, provided investors do not pull their money before the deal closes.
[Fierce Biotech] |
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| June 18 – 22, 2023
Keystone, Colorado, United States |
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| | Royal Melbourne Institute of Technology University – Melbourne, Victoria, Australia |
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| | Recursion Pharmaceuticals – Salt Lake City, Utah, United States |
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| | National Institute of Allergy and Infectious Diseases – Hamilton, Montana, United States |
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| | Center for Disease Neurogenomics at the Icahn School of Medicine – Manhattan, New York, United States |
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| | The National University of Singapore – Singapore, Singapore |
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