 | | Vol. 17.22 – 7 June, 2023 |
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| Investigators showed that brain endothelial cells process and cross-present antigen, leading to effector CD8+ T cell differentiation.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists investigated WDR62 function in corticogenesis through the analysis of a C-terminal truncating mutation. They generated 2D and 3D models of human neurodevelopment, including neuroepithelial stem cells, cerebro-cortical progenitors, terminally differentiated neurons, and cerebral organoids.
[eLife] |
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| Researchers investigated the role of SIRT1 in deoxypodophyllotoxin (DPT)-induced human glioma cell parthanatos. They showed that DPT activated both polymerase 1 and SIRT1, and induced parthanatos in U87 and U251 glioma cells.
[Acta Pharmacologica Sinica] |
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| Scientists evaluated the effect of astaxanthin in preventing rotenone-induced toxicity of SK-N-SH human neuroblastoma cells in an in vitro model of experimental Parkinsonism.
[Food And Chemical Toxicology] |
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| Investigators evaluated the anti-inflammatory effect and elucidated underlying molecular mechanisms of saikosaponins B2 in lipopolysaccharide-induced primary microglia and chronic unpredictable mild stress-induced mice model of depression.
[Journal Of Ethnopharmacology] |
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| A suppressive function of lemur tyrosine kinase 2 (LMTK2) on the proliferative capability and metastatic potential of glioblastoma (GBM) cells was demonstrated by overexpressing LMTK2 in GBM cell lines.
[Biochimica Et Biophysica Acta-Molecular Cell Research] |
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| Researchers treated human microglial cells with Aβ to mimic in vivo microglial activation and neuroinflammation in response to Aβ accumulation, which are the main pathological features of Alzheimer’s disease, and examined the potential immunomodulatory effects of 1,25(OH)2D3 in vitro.
[Biomed Research International] |
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| Scientists investigated if the traditional Chinese medicine, Tangzhiqing (TZQ), could reduce the impact of diabetes-related cognitive impairment in a high-glucose cell model. They found that TZQ treatment increased cell viability, ensured continued mitochondrial activity, and reduced reactive oxygen species.
[Rejuvenation Research] |
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| Investigators generated midbrain dopaminergic organoids from induced pluripotent stem cells from healthy and Parkinson’s Disease (PD) donors and assessed them as a human PD model using single-cell RNAseq.
[Neuroscience Research] |
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| The authors provide an overview of the clinical and translational research that has examined the connection between acute inflammatory insults and Alzheimer’s disease, focusing on three categories of peripheral inflammatory insults; acute infection, critical illness, and surgery.
[Molecular Neurodegeneration] |
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| Investigators present an overview of the multiple layers of glioblastoma heterogeneity and discuss novel findings in the age of single-cell technologies.
[Oncogene] |
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| Professor Paul Yoo had been designing novel electrodes for non-invasive electrical nerve stimulation, a technology that could be used in therapies for the treatment of epilepsy, depression, Parkinson’s disease, and many pain disorders.
[University of Toronto Engineering News] |
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| Nearly $13 million in federal grant funds to study treatments for traumatic brain injury was awarded to UTHealth Houston by the Department of Defense’s Office of Congressionally Directed Medical Research Programs.
[UTHealth Houston] |
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| June 26 – 29, 2023
Boston, Massachusetts, United States |
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| | University of Nevada – Reno, Nevada, United States |
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| | University of Helsinki – Helsinki, Finland |
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| | Royal Melbourne Institute of Technology University – Melbourne, Victoria, Australia |
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| | National Institute of Allergy and Infectious Diseases – Hamilton, Montana, United States |
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| | Center for Disease Neurogenomics at the Icahn School of Medicine – Manhattan, New York, United States |
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