 | | Vol. 17.23 – 14 June, 2023 |
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| Researchers employed poly(A) tail sequencing, mRNA sequencing, ribosome profiling, and small RNA sequencing to explore the functional relationship between mRNA abundance, translation, poly(A) tail length, alternative polyadenylation (APA), and miRNA expression in an in vitro model of neuronal differentiation.
[Nucleic Acids Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists proposed the combination of chitosan and graphene quantum dots in ultrasmall nanoparticles form not as drug carriers but as theranostic agents for Alzheimer’s disease.
[Small] |
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| Researchers found that the levels of ArhGAP11A, a Ras homology GTPase-activating protein, significantly increased in patients with Alzheimer’s disease and amyloid precursor protein/presenilin-1 mice.
[Cell Reports] |
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| Investigators observed the induction of neuronal plasticity and a reduction of neuroinflammation after G9a inhibitor treatment, and these neuroprotective effects were reverted by the pharmacological inhibition of glia maturation factor β (GMFB) in mice and cell cultures.
[Aging And Disease] |
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| Glioblastoma stem cells (GSCs)-derived exosomal miR-6733-5p induced macrophage M2 polarization of tumor-associated macrophages by positively targeting IGF2BP3 to activate the AKT signaling pathway, which further facilitated the self-renewal and stemness of GSCs.
[CNS Neuroscience & Therapeutics] |
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| Investigators established the Rett syndrome brain organoid model derived from MeCP2-truncated induced pluripotent stem cells which were genetically engineered by CRISPR/Cas9 technology.
[Annals Of Clinical And Translational Neurology] |
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| Scientists characterized the downstream cytokine response of human induced pluripotent stem cell-derived microglia when stimulated with five separate cytokines identified following human traumatic brain injury.
[Journal Of Neurotrauma] |
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| Investigators explored the role of Purkinje cell protein 4 (PCP4) in amyloid-β protein precursor processing in Alzheimer’s disease.
[Journal Of Alzheimers Disease] |
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| Researchers developed a novel microfluidic perfusion 3D cell culture system that overcame the disturbance from air bubbles and intuitionally sets the incubation with the perfusion 3D culture. SH-SY5Y differentiation was examined in static 2D, static 3D, and perfusion 3D cultures.
[Biomedical Microdevices] |
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| | Investigators provide an integrated perspective, advocating cross-modal validation of key findings to define functionally important sub-states of astrocytes and their triggers as tractable therapeutic targets with cross-disease relevance.
[Nature Reviews Neurology] |
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| The authors review and propose approaches in utilizing pluripotent stem cells for screening of the impact of environmental chemicals on the development of dopaminergic neurons. Related techniques and gaps in knowledge are also addressed.
[Stem Cell Reviews And Reports] |
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| Scientists discuss literature focusing on clinical observations that suggest associations between SARS-CoV-2 infection and the nervous system.
[Archives of Virology] |
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| Precipio, Inc. announced that it has entered into a collaboration agreement with a New York-based academic healthcare institution to jointly develop a panel for Glioblastoma, an aggressive brain cancer based on Precipio’s HemeScreen technology.
[Precipio, Inc.] |
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| June 26 – 30, 2023
Split, Croatia |
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| | University of Australia – Melbourne, Victoria, Australia |
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| University College London – London, England, United Kingdom |
| | | Karolinska Institutet – Solna, Sweden |
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| University of Nevada – Reno, Nevada, United States |
| | | University of Helsinki – Helsinki, Finland |
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