 | | Vol. 17.24 – 21 June, 2023 |
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| Researchers found that the vast majority of FM 1-43 somatosensory neuron labeling in mice in vivo was dependent on PIEZO2 activity within the peripheral nerve endings. They illustrated the potential of FM 1-43 by using it to identify novel PIEZO2-expressing urethral neurons that are engaged by urination.
[Neuron] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators focused on an unexplored area of Parkinson’s disease pathogenesis by characterizing the interplay between astrocytes, inflammation, and blood-brain barrier (BBB) integrity, and by combining patient-derived induced pluripotent stem cells with microfluidic technologies.
[Nature Communications] |
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| Researchers investigated whether tumor cell proliferation and invasion are interrelated, or rather distinct features of different cell populations. Tumor cell invasion and proliferation were longitudinally determined in real-time using 3D in vivo two-photon laser scanning microscopy over weeks.
[Neuro-Oncology] |
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| Macrophage–cancer hybrid membrane-camouflaged nanoplatforms were fabricated for target gene silencing-enhanced sonodynamic therapy of glioblastoma.
[ACS Applied Materials & Interfaces] |
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| Scientists developed a multiscale, biophysically detailed model of mouse primary motor cortex with over 10,000 neurons and 30 million synapses. The model accurately predicted in vivo layer- and cell-type-specific responses associated with behavioral states and experimental manipulations.
[Cell Reports] |
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| Investigators showed that low expression of AP-2α was correlated with high expression of programmed death-ligand 1 (PD-L1) in high-grade glioma tissues. AP-2α bound directly to the promoter of the CD274 gene enhanced endocytosis and degradation of PD-L1 proteins.
[Cell Death & Disease] |
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| Researchers recapitulated the peripartum neuroimmune profile by depleting microglia in non-mother female rats who were typically not maternal but can be induced to behave maternally towards foster pups after repeated exposure, a process called maternal sensitization.
[Neuropsychopharmacology] |
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| The TRIM25 and Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) double knockdown SHSY5Y cell line was generated, and double knockdown cells exhibited lower proliferation and migration ability than cells with only TRIM25 or G3BP1 knockdown.
[Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms] |
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| Researchers investigated the underlying mechanism of neuronal transient receptor potential vanilloid type 1 (TRPV1) in regulating bone defect repair. In vivo experiments verified that TRPV1 activation could trigger dorsal root ganglion producing the neuropeptide calcitonin gene-related peptide (CGRP) in mice.
[Cellular Signalling] |
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| The authors summarize the recently available studies of miRNAs in post-traumatic stress disorder and traumatic brain injury and discuss and highlight promising miRNAs therapeutics for both conditions in the future.
[Molecular Psychiatry] |
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| ADvantage Therapeutics, Inc. announced that regulatory authorities in Poland, Bulgaria, and Slovakia have approved its Clinical Trial Application to conduct a clinical trial on its lead candidate, AD04™ for the treatment of mild Alzheimer’s disease in each respective country.
[ADvantage Therapeutics, Inc. ] |
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| July 2 – 7, 2023
Vaud, Switzerland |
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| | University of Amsterdam – Amsterdam, Netherlands |
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| | University of Gothenburg – Gothenburg, Sweden |
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| | University of Australia – Melbourne, Victoria, Australia |
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| | University College London – London, England, United Kingdom |
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| | Karolinska Institutet – Solna, Sweden |
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