Neural Cell News Volume 17.25 | June 28 2023

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    Jamie Kang
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    2023-06-28 | NCN 17.25


    Neural Cell News by STEMCELL Technologies
    Vol. 17.25 – 28 June, 2023
    TOP STORY

    Schizophrenia-Associated NRXN1 Deletions Induce Developmental-Timing- and Cell-Type-Specific Vulnerabilities in Human Brain Organoids

    Researchers leveraged human pluripotent stem cell-derived forebrain organoid models carrying NRXN1 heterozygous deletions in isogenic and schizophrenia patient genetic backgrounds and conducted single-cell transcriptomic analysis over the course of brain organoid development from 3 weeks to 3.5 months.
    [Nature Communications]

    Full Article
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    Regulation of LRRK2 mRNA Stability by ATIC and Its Substrate AICAR through ARE-Mediated mRNA Decay in Parkinson’s Disease

    Scientists identified a role for the purine biosynthesis pathway enzyme ATIC in the regulation of LRRK2 levels and toxicity. AICAr, the precursor of ATIC substrate, regulated LRRK2 levels in a cell-type-specific manner in vitro and in mouse tissue.
    [EMBO Journal]

    AbstractGraphical Abstract

    3D Bioengineered Neural Tissue Generated from Patient-Derived iPSCs Mimics Time-Dependent Phenotypes and Transcriptional Features of Alzheimer’s Disease

    Investigators developed a 3D bioengineered model of induced pluripotent stem cell (iPSC)-derived neural tissue that combines a porous scaffold composed of silk fibroin protein with an intercalated collagen hydrogel to support the growth of neurons and glial cells into complex and functional networks.
    [Molecular Psychiatry]

    Abstract

    Impaired AIF-CHCHD4 Interaction and Mitochondrial Calcium Overload Contribute to Auditory Neuropathy Spectrum Disorder in Patient-iPSC-Derived Neurons with AIFM1 Variant

    Scientists generated induced pluripotent stem cells (iPSCs) from peripheral blood mononuclear cells via nucleofection with episomal plasmids. The patient-specific iPSCs were edited via CRISPR/Cas9 technology to generate gene-corrected isogenic iPSCs.
    [Cell Death & Disease]

    Full Article

    GABAergic Neurons Differentiated from BDNF- and Dlx2-Modified Neural Stem Cells Restore Disrupted Neural Circuits in Brainstem Stroke

    Researchers demonstrated that brain-derived neurotrophic factor (BDNF)- and distal-less homeobox 2 (Dlx2)-modified neural stem cells differentiated into GABAergic neurons, integrated into and reconstituted the host neural networks, and alleviated the ischemic injury.
    [Stem Cell Research & Therapy]

    Full Article

    Differentiation State and Culture Conditions Impact Neural Stem/Progenitor Cell-Derived Extracellular Vesicle Bioactivity

    The authors assessed whether oligodendrocyte precursor cells and immature oligodendrocytes could yield extracellular vesicles with neurotherapeutic properties comparable or superior to those from neural progenitor/stem cells.
    [Biomaterials Science]

    AbstractGraphical Abstract

    The Overexpression and Clinical Significance of TBX15 in Human Gliomas

    Investigators explored the prognostic value of T-box transcription factor 15 (TBX15) and its link to glioma immune infiltration and examine TBX15 expression in pan-cancer using RNAseq data in TPM format from TCGA and GTEx.
    [Scientific Reports]

    Full Article

    SLC25A32 Promotes Malignant Progression of Glioblastoma by Activating PI3K-AKT Signaling Pathway

    Folate related gene analysis was performed to explore gene expression profiles in low-grade glioma and glioblastoma (GBM). Researchers demonstrated that solute carrier family 25 member 32 (SLC25A32) played a significant role in promoting the malignant phenotype of GBM.
    [BMC Cancer]

    Full Article

    PEG-SH-GNPs-SAPNS@miR-29a Delivery System Promotes Neural Regeneration and Recovery of Motor Function After Spinal Cord Injury

    Investigators designed a PEG-SH-GNPs-SAPNS@miR-29a delivery system to repair impaired spinal cord by building a regenerative microenvironment for the recruitment of endogenous neural stem cells.
    [Journal Of Biomaterials Science-Polymer Edition]

    Abstract
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    REVIEWS

    Scaffold-Based Spheroid Models of Glioblastoma Multiforme and Its Use in Drug Screening

    The authors summarize the development of various scaffold-based glioblastoma multiforme spheroid models and their potential use as drug testing systems.
    [Biotechnology And Bioengineering]

    Abstract
    INDUSTRY AND POLICY NEWS

    Rezolute to Initiate a Pivotal Phase III Study of RZ358 in Participants 3 Months of Age and Older with Congenital Hyperinsulinism

    Rezolute, Inc. plans to initiate sunRIZE, a pivotal Phase II clinical study of RZ358, in Europe and other geographies outside the US in Q4 2023.
    [Rezolute, Inc.]

    Press Release


    Beyond Air®
    Licenses Commercial Rights to Selective Neuronal Nitric Oxide Synthase (nNOS) Inhibitors for the Treatment of Autism Spectrum Disorder from Hebrew University of Jerusalem

    Beyond Air, Inc. announced that it has entered into an agreement with Yissum Research Development Company to license the commercial rights for multiple nNOS inhibitor candidates, currently being developed for the treatment of autism spectrum disorder and other neurological conditions.
    [Beyond Air, Inc.]

    Press Release
    FEATURED EVENT

    3rd Tumor Myeloid-Directed Therapies Summit

    July 18 – 20, 2023
    Boston, Massachusetts, United States

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    JOB OPPORTUNITIES

    Postdoctoral Researcher – Neurodegenerative Models Using iPSCs

    The Buck Institute – San Francisco, California, United States

    Postdoctoral Scholar – Neural & Behavioral Sciences

    Pennsylvania State University – State College, Pennsylvania, United States

    PhD Position – Neurally-Informed Artificial Networks

    University of Amsterdam – Amsterdam, Netherlands

    Postdoctoral Position – Perinatal Neuroscience

    University of Gothenburg – Gothenburg, Sweden

    PhD Position – Targeting Calcitonin Receptor to Treat Glioblastoma

    University of Australia – Melbourne, Victoria, Australia

    > See All Jobs

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