| Vol. 17.26 – 5 July, 2023 |
| | | Through an electric-chemical field, bioelectrical signal exchange and communication with endogenous neural stem cells were allowed, thus allowing for regulated proliferation and directed neuron differentiation in vivo. [Advanced Materials] |
| | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists described a microphysiological system integrating alveolus and blood–brain barrier tissue chips that recapitulated neuropathogenesis associated with infection by SARS-CoV-2. [Nature Biomedical Engineering] |
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| Researchers investigated circular RNA expression in the pediatric malignancy, neuroblastoma, through deep whole-transcriptome sequencing in 104 primary neuroblastomas covering all risk groups. [Nature Communications] |
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| Investigators reported Ca2+ and developmental dysregulations related to store-operated Ca2+ entry in bipolar disorder patient induced pluripotent stem cell (iPSC)-derived neural progenitor cells and cortical-like glutamatergic neurons. [Molecular Psychiatry] |
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| Researchers found that PI3K inhibition induced hyperglycemia and hyperinsulinemia in mice and that combining metformin with PI3K inhibition improved treatment efficacy in an orthotopic glioblastoma xenograft model. [Neuro-Oncology] |
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| Combining lineage tracing with single-cell RNA sequencing of clonally related cells, scientists showed at the cellular level that disruptor of telomeric silencing-like 1 (DOT1L) inhibition increased neurogenesis driven by a shift of apical progenitors from asymmetric self-renewing to symmetric neurogenic consumptive divisions. [EMBO Reports] |
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| Investigators profiled the expression and function of nicotinic acetylcholine receptor subtypes during midbrain dopaminergic neuron differentiation from human-induced pluripotent stem cells. [Neuropsychopharmacology Reports] |
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| Scientists studied whether alterations in both cAMP response element-binding protein binding protein (CREBBP) and v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) genes cooperated to induce brain tumor formation. [Oncogenesis] |
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| Investigators examined the antitumor effect of extremely low-frequency electromagnetic fields (ELF-EMF) on U87 and U251 glioblastoma cell lines. Flow cytometry determined the viability/apoptosis and distribution of cells in different phases of the cell cycle. [Scientific Reports] |
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| The authors discuss the applications of brain organoids in studying preterm birth associated brain dysfunction; viral infections mediated neuroinflammation, neurodevelopmental and neurodegenerative diseases. [Cell Death Discovery] |
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| Scientists review the molecular foundations for understanding the mechanism of SARS-CoV-2 invading the human brain and the molecular basis of SARS-CoV-2 infection interfering with brain and memory. [Cell Death Discovery] |
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| Genenta’s platform is designed to avoid systemic toxicity of interferon alpha and selectively deliver therapeutic activity within solid tumors like glioma. [Genenta Science] |
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| July 9 – 14, 2023 Barcelona, Spain |
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| National Institutes of Health – Houston, Texas, United States |
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| The Buck Institute – San Francisco, California, United States |
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| Pennsylvania State University – State College, Pennsylvania, United States |
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| University of Gothenburg – Gothenburg, Sweden |
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| University of Nevada – Reno, Nevada, United States |
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