Neural Cell News Volume 17.26 | Jul 05 2023

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    2023-07-05 | NCN 17.26


    Neural Cell News by STEMCELL Technologies
    Vol. 17.26 – 5 July, 2023
    TOP STORY

    Directed Neural Stem Cells Differentiation via Signal Communication with Ni-Zn Micromotors

    Through an electric-chemical field, bioelectrical signal exchange and communication with endogenous neural stem cells were allowed, thus allowing for regulated proliferation and directed neuron differentiation in vivo.
    [Advanced Materials]

    Abstract
    Explore neural organoid technologies with this free wallchart from STEMCELL and Nature Neuroscience
    PUBLICATIONSRanked by the impact factor of the journal

    Blood–Brain Barrier Injury and Neuroinflammation Induced by SARS-CoV-2 in a Lung–Brain Microphysiological System

    Scientists described a microphysiological system integrating alveolus and blood–brain barrier tissue chips that recapitulated neuropathogenesis associated with infection by SARS-CoV-2.
    [Nature Biomedical Engineering]

    Abstract

    Defining the Landscape of Circular RNAs in Neuroblastoma Unveils a Global Suppressive Function of MYCN

    Researchers investigated circular RNA expression in the pediatric malignancy, neuroblastoma, through deep whole-transcriptome sequencing in 104 primary neuroblastomas covering all risk groups.
    [Nature Communications]

    Full Article

    Bipolar Disorder-iPSC Derived Neural Progenitor Cells Exhibit Dysregulation of Store-Operated Ca2+ Entry and Accelerated Differentiation

    Investigators reported Ca2+ and developmental dysregulations related to store-operated Ca2+ entry in bipolar disorder patient induced pluripotent stem cell (iPSC)-derived neural progenitor cells and cortical-like glutamatergic neurons.
    [Molecular Psychiatry]

    Full Article

    Insulin Feedback Is a Targetable Resistance Mechanism of PI3K Inhibition in Glioblastoma

    Researchers found that PI3K inhibition induced hyperglycemia and hyperinsulinemia in mice and that combining metformin with PI3K inhibition improved treatment efficacy in an orthotopic glioblastoma xenograft model.
    [Neuro-Oncology]

    Abstract
    Graphical Abstract

    DOT1L Activity Affects Neural Stem Cell Division Mode and Reduces Differentiation and Asns Expression

    Combining lineage tracing with single-cell RNA sequencing of clonally related cells, scientists showed at the cellular level that disruptor of telomeric silencing-like 1 (DOT1L) inhibition increased neurogenesis driven by a shift of apical progenitors from asymmetric self-renewing to symmetric neurogenic consumptive divisions.
    [EMBO Reports]

    Full ArticleGraphical Abstract

    Expression and Role of Nicotinic Acetylcholine Receptors during Midbrain Dopaminergic Neuron Differentiation from Human Induced Pluripotent Stem Cells

    Investigators profiled the expression and function of nicotinic acetylcholine receptor subtypes during midbrain dopaminergic neuron differentiation from human-induced pluripotent stem cells.
    [Neuropsychopharmacology Reports]

    Full Article

    The Tumor Suppressor CREBBP and the Oncogene MYCN Cooperate To Induce Malignant Brain Tumors in Mice

    Scientists studied whether alterations in both cAMP response element-binding protein binding protein (CREBBP) and v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) genes cooperated to induce brain tumor formation.
    [Oncogenesis]

    Full Article

    P53 Status, and G2/M Cell Cycle Arrest, Are Determining Factors in Cell-Death Induction Mediated by ELF-EMF in Glioblastoma

    Investigators examined the antitumor effect of extremely low-frequency electromagnetic fields (ELF-EMF) on U87 and U251 glioblastoma cell lines. Flow cytometry determined the viability/apoptosis and distribution of cells in different phases of the cell cycle.
    [Scientific Reports]

    Full Article
    Dr. Kristina McBurney and Leanna Bedell discuss how you can use social media to advance your scientific career. Watch now.
    REVIEWS

    Human 3D Brain Organoids: Steering the Demolecularization of Brain and Neurological Diseases

    The authors discuss the applications of brain organoids in studying preterm birth associated brain dysfunction; viral infections mediated neuroinflammation, neurodevelopmental and neurodegenerative diseases.
    [Cell Death Discovery]

    Full Article

    Long-Term Effects of SARS-CoV-2 Infection on Human Brain and Memory

    Scientists review the molecular foundations for understanding the mechanism of SARS-CoV-2 invading the human brain and the molecular basis of SARS-CoV-2 infection interfering with brain and memory.
    [Cell Death Discovery]

    Full ArticlePress Release
    INDUSTRY AND POLICY NEWS

    The European Commission Grants Orphan Drug Designation to Temferonâ„¢ for Treatment of Glioma

    Genenta’s platform is designed to avoid systemic toxicity of interferon alpha and selectively deliver therapeutic activity within solid tumors like glioma.
    [Genenta Science]

    Press Release
    FEATURED EVENT

    Amygdala Function in Emotion, Cognition, and Disease

    July 9 – 14, 2023
    Barcelona, Spain

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    JOB OPPORTUNITIES

    PhD Position – Models of Motor Neuron Degeneration

    National Institutes of Health – Houston, Texas, United States

    Postdoctoral Researcher – Neurodegenerative Models Using iPSCs

    The Buck Institute – San Francisco, California, United States

    Postdoctoral Scholar – Neural & Behavioral Sciences

    Pennsylvania State University – State College, Pennsylvania, United States

    Postdoctoral Position – Perinatal Neuroscience

    University of Gothenburg – Gothenburg, Sweden

    Postdotoral Scholar – Neural Mechanisms of Cardiovascular & Metabolic Physiology

    University of Nevada – Reno, Nevada, United States

    > See All Jobs

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