 | | Vol. 17.27 – 12 July, 2023 |
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| Researchers uncovered and functionally defined pathogenic variants in the chromatin modifier EZH1 as the cause of dominant and recessive neurodevelopmental disorders in 19 individuals.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists characterized in situ ultrastructural and transcriptional responses of glial cells and infiltrating T cells after demyelinating brain injury in male mice. They identified a population of lipid-loaded “foamy” microglia located in the center of remyelinating lesion.
[Nature Communications] |
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| Investigators used APP/PS1dE9 mouse model and induced Ngfr expression in the hippocampus. Ngfr, which promotes neurogenic fate of astroglia during the amyloid pathology-induced neuroregeneration in zebrafish brain, stimulated proliferative and neurogenic outcomes.
[NPJ Regenerative Medicine] |
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| Researchers reported that Absent, small or homeotic discs-like 2 (Ash2l), one core component of a multimeric histone methyltransferase complex, was essential for neural stem/progenitor cell fate determination during postnatal neurogenesis.
[Cell Death & Differentiation] |
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| Using a combination of electrophysiological and imaging approaches in glioblastoma U87-MG cells, investigators found that hypotonic-induced cell swelling triggered the opening of Ca2+-activated K+ channels of large and intermediate conductance, both highly expressed in glioblastoma cells.
[Journal Of Cellular Physiology] |
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| Researchers showed that kinesin family member 2C (KIF2C) regulated the transport of mGlu1 receptors in Purkinje cells by binding to Rab8. KIF2C deficiency in Purkinje cells results in abnormal gait, reduced balance ability, and motor incoordination in male mice.
[Journal Of Physiology] |
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| Scientists investigated the neuromodulatory capacity of human milk of premature infants on the olfactory bulb. A high bioactivity of human preterm colostrum on murine neonatal neurogenic tissue was demonstrated to be associated with a proteome profoundly differing from mature milk.
[Pediatric Research] |
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| Methylglyoxal cytotoxicity was evaluated employing a human stem cell-derived model, namely, neuron-like cells transdifferentiated from mesenchymal stem/stromal cells, which served as a source of human based species-specific “healthy” cells.
[Journal Of Applied Toxicology] |
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| Researchers presented the development and validation of a fully automated and efficient microglia detection method using the YOLOv3 deep learning-based algorithm. They applied this method to analyze the number of microglia in different spinal cord and brain regions of rats.
[Scientific Reports] |
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| Scientists review the application and progress of nanomedicine delivery systems in brain tumors, summarizing the mechanism of nanomaterials crossing the blood-brain barrier. Furthermore, the specific application of nanotechnology in glioblastoma is discussed in depth.
[Small] |
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| The authors explore the multifaceted interaction between SMARCA4 and various brain cancer types, highlighting its roles in tumor pathogenesis, the pathways it regulates, and the advances that have been made in understanding the functional relevance of mutations.
[Oncogene] |
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| CANbridge Pharmaceuticals, Inc. announced that, based on the interim analysis recommendation of the independent data monitoring committee, it plans to continue the ongoing Phase II study of CAN008 in patients with newly diagnosed GBM in China to completion.
[CANbridge Pharmaceuticals, Inc.] |
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| August 3, 2023
New York, New York, United States |
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| | King’s College London – London, England, United Kingdom |
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| | NCI Center for Cancer Research – Bethesda, Maryland, United States |
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| | Forschungszentrum Jülich – Jülich, Germany |
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| | University of Florida – Gainesville, Florida, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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