Neural Cell News Volume 17.28 | Jul 19 2023

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    Jamie Kang
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    2023-07-10 | NCN 17.28


    Neural Cell News by STEMCELL Technologies
    Vol. 17.28 – 19 July, 2023
    TOP STORY

    Identification of Ligand–Receptor Pairs that Drive Human Astrocyte Development

    Investigators used published transcriptomic data to identify and functionally test five ligand–receptor pairs that synergistically drive human astrogenesis.
    [Nature Neuroscience]

    Abstract
    The complex genettics of schizophrenia are unclear. So she developed a new approach.
    PUBLICATIONSRanked by the impact factor of the journal

    Imbalanced Unfolded Protein Response Signaling Contributes to 1-Deoxysphingolipid Retinal Toxicity

    Scientists integrated bulk and single-nucleus RNA-sequencing to define biological pathways that modulate cytotoxic 1-deoxysphingolipids toxicity in human retinal organoids.
    [Nature Communications]

    Full Article

    Lysine Methylation Promotes NFAT5 Activation and Determines Temozolomide Efficacy in Glioblastoma

    Researchers showed that tonicity-responsive enhancer binding protein (NFAT5) lysine methylation, was a determinant of Temozolomide response. Mechanistically, EGFR activation induced phosphorylated EZH2 binding and triggered NFAT5 methylation at K668.
    [Nature Communications]

    Full Article

    AraC Interacts with p75NTR Transmembrane Domain to Induce Cell Death of Mature Neurons

    Researchers studied whether the upregulation of the death receptor p75NTR was responsible for Cytosine arabinoside (AraC)-mediated neurodegeneration and cell death in leukemia patients undergoing AraC treatment.
    [Cell Death & Disease]

    Full Article

    TRPC Channels Activated by G Protein-Coupled Receptors Drive Ca2+ Dysregulation Leading to Secondary Brain Injury in the Mouse Model

    Sustained activation of canonical transient receptor potential (TRPC) channel-based pathophysiological signaling hub in neurons and glia likely contributed to prodigious excitotoxicity-driven secondary brain injury expansion. Scientists investigated in mouse models with selective Trpc gene knockout.
    [Translational Stroke Research]

    Full Article

    FAM201A Encodes Small Protein NBASP to Inhibit Neuroblastoma Progression via Inactivating MAPK Pathway Mediated by FABP5

    Investigators found that family with sequence similarity, with the 201 member A (FAM201A) was lowly expressed in neuroblastoma and a variety of gain and loss of function studies.
    [Communications Biology]

    Full Article

    Glutathione Trisulfide Prevents Lipopolysaccharide-Induced Retinal Inflammation via Inhibition of Proinflammatory Cytokine Production in Glial Cells

    Scientists investigated the impact of glutathione trisulfide on lipopolysaccharide (LPS)-induced inflammation in retinal glia. Inflammatory responses in mouse-derived glial cells and Wistar rat retinas were stimulated with administration of LPS.
    [Scientific Reports]

    Full Article

    Disruption of Neuronal RHEB Signaling Impairs Oligodendrocyte Differentiation and Myelination through mTORC1-DLK1 Axis

    Researchers showed that dysregulated neuronal RHEB-mTORC1-DLK1 axis impaired brain myelination. Neuronal Rheb cKO impaired oligodendrocyte differentiation/myelination, with activated neuronal expression of the imprinted gene Dlk1.
    [Cellular Signalling]

    Full ArticleGraphical Abstract

    Effect of Folic Acid-Linked Chitosan-Coated PLGA-Based Curcumin Nanoparticles on the Redox System of Glioblastoma Cancer Cells

    Investigators prepared PLGA-based curcumin nanoparticles changed with folic acid and chitosan and evaluated its effects on glioblastoma multiforme tumor cells’ redox status.
    [Phytochemical Analysis]

    Abstract
    Virtual Poster Presentation: CRISPR-Cas9 Gene Editing of Cerebral Organoids to Model Microcephaly
    REVIEWS

    Flavonoids in Combination with Stem Cells for the Treatment of Neurological Disorders

    The authors first introduce flavonoid compounds and provide background information on stem cells. They then compile available reports on the effects of flavonoids on stem cells for the treatment of neurological disorders.
    [Neurochemical Research]

    Abstract

    Heavy Metal Mediated Progressive Degeneration and Its Noxious Effects on Brain Microenvironment

    Scientists consolidate recent research on the harmful effects of various metals on specific brain cells. Studies that are done using bioinformatics tools, microRNAs, long non-coding RNAs, emerging disease models, and studies based on the modes of exposure to toxic metals are a future prospect to be explored.
    [Biological Trace Element Research]

    Abstract
    INDUSTRY AND POLICY NEWS

    Ivy Brain Tumor Center Opens Novel Clinical Trial to Test Direct-to-Tumor Drug Delivery Method

    In an effort to discover new treatments for brain tumors, such as glioblastoma, the Ivy Brain Tumor Center at Barrow Neurological Institute, announced the initiation of a ground-breaking Phase 0 clinical trial that tests a new experimental drug delivery method called superselective intra-arterial infusion, or SSIAI.
    [Ivy Brain Tumor Center]

    Press Release
    FEATURED EVENT

    2023 Cerebellum Conference GRC

    August 6 – 11, 2023
    Lewiston, Maine, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Tensor Decomposition for Efficient Neural Networks

    Delft University of Technology – Delft, Netherlands

    Faculty Positions – Advanced Immunochemical Studies

    ShanghaiTech University – Shanghai, China

    Postdoctoral Research Associate – Developmental Neuroscience

    King’s College London – London, England, United Kingdom

    Scientific Director – Clinical Research

    NCI Center for Cancer Research – Bethesda, Maryland, United States

    Doctoral Position – Organoid Model for Traumatic Brain Injury

    For­schungs­zentrum Jülich – Jülich, Germany

    > See All Jobs

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