 | | Vol. 17.29 – 26 July, 2023 |
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| To investigate whether healthy glia can outcompete diseased human glia in the adult forebrain, scientists engrafted wild-type human glial progenitor cells (hGPCs) produced from human embryonic stem cells into the striata of adult mice that had been neonatally chimerized with mutant Huntingtin-expressing hGPCs.
[Nature Biotechnology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that circular MET RNA (circMET) encoded a 404-amino-acid MET variant (MET404) facilitated by the N6-methyladenosine reader YTHDF2. Genetic ablation of circMET inhibited MET404 expression in mice and attenuated MET signaling.
[Nature Communications] |
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| Multiple 4A7C-derivatives were found to enhance Nurr1’s transcriptional activity, leading to the identification of an optimized, brain-penetrant agonist, 4A7C-301, that exhibited robust neuroprotective effects in vitro.
[Nature Communications] |
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| Long-term suppression of neurogenesis as occurred during stress and aging resulted in an accelerated decline in hippocampal acetylcholine signaling and a slow and progressing emergence of profound working memory deficits.
[Molecular Psychiatry] |
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| Clusterin (CLU) rs11136000 single-nucleotide polymorphism (SNP) was identified as a functional variant by a small-scale CRISPR-Cas9 screen. Astrocytes derived from isogenic induced pluripotent stem cells (iPSCs) carrying the “C” or “T” allele of the CLU rs11136000 SNP exhibited different CLU expression levels.
[Cell Reports] |
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| Investigators found that induction of HTATIP2 expression in glioblastoma multiforme cells led to a significant shift of predominantly nuclear to cytoplasmic MPG, whereas depletion of endogenous HTATIP2 resulted in enhanced nuclear MPG localization.
[Molecular Oncology] |
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| Researchers proposed an integrative method to identify the personalized driver gene sets by integrating the profiles of gene expression and genetic alterations in cancer individuals. The personalized driver gene sets were identified for 99 glioblastoma multiforme individuals using this method.
[Molecular Oncology] |
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| Investigators identified SLITRK1 as a downregulated gene in neural stem cells (NSCs) differentiated from Prader-Willi syndrome (PWS) patient-induced pluripotent cells by RNA sequencing analysis.
[Scientific Reports] |
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| Scientists evaluated the expression levels of galectin-3 in different cellular populations involved in the etiopathogenesis of multiple sclerosis (MS) and observed dramatically higher transcriptomic levels of galectin-3 in encephalitogenic CD4+ T cells in a preclinical model of MS.
[Immunologic Research] |
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| Investigators provide an overview of major advances in our understanding of the cell-specific molecular and cellular mechanisms of GABA synthesis, release, and clearance that regulate GABA tone in various brain regions.
[Nature Reviews Neuroscience] |
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| The authors discuss the role of Wnt signaling in the reported causes of ALS such as oxidative stress, mitochondrial dysfunction, autophagy, and apoptosis.
[Cellular Signalling] |
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| | Researchers from biotechnology startup Axonis are working to improve treatments for patients with disorders like Alzheimer’s and Parkinson’s by leveraging the International Space Station (ISS) National Laboratory, examining how microgravity affects the maturation of human brain cells that form 3D spheroids.
[ISS National Laboratory] |
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| Fred Hutchinson Cancer Center developmental biologist Cecilia Moens, PhD recently received a prestigious Javits Neuroscience Investigator Award. The new grant will allow Dr. Moens to better understand the cues that help growing neurons find their way through a developing embryo to form sensory-motor neural circuits.
[Fred Hutch Cancer Center] |
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| August 6 – 11, 2023
Newry, Maine, United States |
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| | University of Calgary – St. Albert, Alberta, Canada |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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| | NICHD – Bethesda, Maryland, United States |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | Delft University of Technology – Delft, Netherlands |
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