 | | Vol. 17.31 – 9 August, 2023 |
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| A platform for modeling human microglia transcriptional states in vitro was developed. Exposure of human stem-cell-differentiated microglia to synaptosomes, myelin debris, apoptotic neurons, or synthetic amyloid-beta fibrils generated transcriptional diversity that mapped to gene signatures identified in human microglia.
[Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that Smad nuclear interacting protein 1 (SNIP1) promoted neural progenitor cell survival and neurogenesis and was, therefore, integral to brain development.
[Nature Communications] |
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| Researchers showed that, in mouse lines carrying Alzheimer’s disease-related mutations, a loss of neuronal membrane potassium-chloride cotransporter KCC2, responsible for maintaining the robustness of GABAA-mediated inhibition, occurred pre-symptomatically in the hippocampus and prefrontal cortex.
[Brain] |
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| Investigators found brain specific deletion of Pd1 results in abnormal cortical neurogenesis, including enhanced proliferation of neural progenitors and reduced neuronal differentiation.
[Cell Death & Differentiation] |
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| Scientists discovered severe neurogenic deficits and hippocampal-based spatial memory defects accompanied by increased neuroblast death and high loss of newly formed neurons in kinase D-interacting substrate of 220 kDa (Kidins220) deficient mice.
[Cell Death & Disease] |
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| Investigators used imaging mass cytometry to overcome challenges in understanding the contribution of mitochondrial dysfunction to Parkinson’s disease pathogenesis, measuring multiple protein targets, whilst retaining the spatial relationship between targets in post-mortem midbrain sections.
[npj Parkinson’s Disease] |
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| Scientists showed that transient receptor potential canonical-6 (TRPC6) knockout reduced store-operated calcium entry signaling and led to hyperexcitability of neurons by increasing action potential frequency and network burst frequency.
[Molecular Neurobiology] |
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| Researchers demonstrated that menstrual stromal cells-derived planar presenilin 1 (PSEN 1) I416T cholinergic-like cells and cerebral spheroids reproduced the typical neuropathological markers of familial Alzheimer’s disease in four post-transdifferentiating or 11 days of transdifferentiating, respectively.
[Scientific Reports] |
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| Scientists tested whether astrocytes-neuron lactate shuttle activation could be another potential underpinning mechanism that complements collateral flow in the protection process.
[Scientific Reports] |
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| The impact of the diverse types of self-extracellular nucleic acids on neuroinflammatory and neurodegenerative diseases was discussed. Several specific antagonistic approaches are presented that could serve as therapeutic interventions to lower the pathological outcome of the indicated brain disorders.
[Journal Of Biomedical Science] |
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| | Under-representation of people of color sparks concerns over the safety and efficacy of drugs in diverse populations. Black and Hispanic people are up to twice as likely as white people to develop Alzheimer’s disease, but they have a much lower chance of being included in clinical trials for Alzheimer’s treatments.
[Nature] |
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| September 6 – 8, 2023
Hinxton, England, United Kingdom |
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| | Weill Cornell – New York City, New York, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Goethe University Frankfurt – Frankfurt, Germany |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Florida – Gainesville, Florida, United States |
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