Neural Cell News Volume 17.32 | Aug 16 2023

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    2023-08-16 | NCN 17.32


    Neural Cell News by STEMCELL Technologies
    Vol. 17.32 – 16 August, 2023
    TOP STORY

    Optical Blood-Brain-Tumor Barrier Modulation Expands Therapeutic Options for Glioblastoma Treatment

    Researchers analyzed the intratumoral blood-brain-tumor barrier heterogeneity in human glioblastoma and characterized two genetically engineered models in female mice that recapitulated two important glioma phenotypes.
    [Nature Communications]

    Full Article
    View-On-Demand Webinar: Therapeutic Application of Endothelial Colony-Forming Cells. Watch Now.
    PUBLICATIONSRanked by the impact factor of the journal

    Astrocyte-Targeting Therapy Rescues Cognitive Impairment Caused by Neuroinflammation via the Nrf2 Pathway

    The authors identified the therapeutic target NF-E2-related factor 2 (Nrf2) that modulated neuroinflammation-triggered reactive astrocyte conversion.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Cdon Ablation in Motor Neurons Causes Age-Related Motor Neuron Degeneration and Impaired Sciatic Nerve Repair

    Investigators demonstrated the functional importance of cell adhesion molecule-downregulated oncogene (Cdon) in motor neuron function and nerve repair.
    [Journal Of Cachexia Sarcopenia And Muscle]

    Full Article

    Spatial Distribution and Functional Relevance of FGFR1 and FGFR2 Expression for Glioblastoma Tumor Invasion

    Scientists investigated the distribution and functional relevance of fibroblast growth factor receptor 1 (FGFR1) and FGFR2 in human glioblastoma xenograft models.
    [Cancer Letters]

    Full Article

    A Virally Encoded GPCR Drives Glioblastoma through Feed-Forward Activation of the SK1-S1P1 Signaling Axis

    Researchers showed that US28 increased the malignancy of U251 glioblastoma cells by enhancing signaling mediated by sphingosine-1-phosphate (S1P), a bioactive lipid that stimulated oncogenic pathways in glioblastoma.
    [Science Signaling]

    Abstract

    NeuroD4 Converts Glioblastoma Cells into Neuron-Like Cells through the SLC7A11-GSH-GPX4 Antioxidant Axis

    Investigators employed Neuronal Differentiation 4 (NeuroD4), a crucial transcription factor in neuronal development, to reprogram glioblastoma cells into neuron-like cells.
    [Cell Death Discovery]

    Full Article

    Asymmetric Charge Balanced Waveforms Direct Retinal Ganglion Cell Axon Growth

    Researchers demonstrated that a new class of asymmetric, charge balanced waveforms were effective at directing retinal ganglion cell axon growth, in vitro, without compromising cell viability.
    [Scientific Reports]

    Full Article

    STIM2 Suppression Blocks Glial Activation to Alleviate Brain Ischemia Reperfusion Injury via Inhibition of Inflammation and Pyroptosis

    The authors investigated the biological functions of stromal interactive molecule 2 (STIM2) and its related mechanisms in cerebral ischemia/reperfusion injury progression.
    [Molecular Biotechnology]

    Abstract

    PLK3 Promotes the Proneural–Mesenchymal Transition in Glioblastoma via Transcriptional Regulation of C5AR1

    Scientists defined the role of polo-like kinase 3 (PLK3)-dependent proneural–mesenchymal transition in glioblastoma therapy.
    [Molecular Biology Reports]

    Abstract
    He knew neuronal cultures should be active. So he invented a new medium. Watch Cedric Bardy's webinar.
    REVIEWS

    Clinical Theranostics Trademark of Exosome in Glioblastoma Metastasis

    The authors explore the exosome–glioblastoma (GBM) interlink, the clinical impact of exosomes on GBM biomarkers, the therapeutics signature of exosomes in GBM, exosome-based research challenges, and future directions in GBM.
    [ACS Biomaterials Science & Engineering]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Brain Tumor SPORE Receives $10.8 Million NCI Award Renewal

    The Robert H. Lurie Comprehensive Cancer Center of Northwestern University has received a renewed $10.8 million Specialized Program of Research Excellence (SPORE) grant to advance translational research and improve outcomes for patients with brain cancer.
    [Northwestern University]

    Press Release
    FEATURED EVENT

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    October 1 – 4, 2023
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    JOB OPPORTUNITIES

    Faculty Position – Neurodegenerative Science

    Van Andel Institute – Grand Rapids, Michigan, United States

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

    Principal Investigators – Molecular Cell Science

    Center for Excellence in Molecular Cell Science – Shanghai, China

    Postdoctoral Researcher – Neural Dynamics

    Weill Cornell – New York, New York, United States

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

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