 | | Vol. 17.33 – 23 August, 2023 |
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| Researchers found that high-mobility group box 1 (Hmgb1), normally upregulated with injury and involved in adult cerebrovascular repair, was highly expressed in astrocytes at birth and then decreased rapidly.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators identified HDAC2 as the most relevant histone deacetylase for re-organization of chromatin accessibility resulting in maintenance of brain tumor stem cell growth and self-renewal properties.
[Nature Communications] |
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| Scientists interrogated the developing neural transcriptome in two experimental model systems with complementary advantages: isogenic human cortical organoids and isocortex from the 1.6-megabase deletion at chromosome 3q29 mouse model.
[Science Advances] |
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| To interrogate the roles of SORL1 in human brain cells, SORL1-null induced pluripotent stem cells were differentiated to neuron, astrocyte, microglial, and endothelial cell fates.
[Cell Reports] |
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| The authors investigated whether MKP-1 could regulate microglia phenotype and inflammatory factor release in Alzheimer’s disease and explored its possible mechanisms.
[CNS Neuroscience & Therapeutics] |
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| Researchers showed that Dbx2 expression was downregulated by epidermal growth factor receptor signaling, which promoted neural/stem progenitor cells proliferation and decreased in the aged subventricular zone.
[Stem Cell Reviews and Reports] |
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| Investigators proposed a novel approach to emulate mild and moderate traumatic brain injury (TBI) using human cerebral organoids that undergo strain rates indicative of TBI.
[Scientific Reports] |
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| The authors investigated the utilization of electrospraying process to fabricate minocycline-loaded poly(lactic-co-glycolic acid) (PLGA) microparticles and evaluated their ability to induce cell toxicity in human glioblastoma cells.
[Biotechnology And Bioengineering] |
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| Researchers developed a functional collagen scaffold by loading SDF-1α and nanoparticle-encapsulated PLGA-paclitaxel (PTX) into a 3D collagen porous scaffold, allowing for slow release of PTX.
[Journal Of Biomaterials Science-Polymer Edition] |
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| Scientists highlight the importance of HBP/O-GlcNAcylation in the neuronal system and summarize the roles and potential mechanisms of O-GlcNAcylated neuronal proteins in maintaining normal brain function and initiation and progression of neurological diseases.
[American Journal Of Physiology-Cell Physiology] |
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| The National Institute on Aging of the NIH has awarded Dr. Yingxue Wang $1,038,819 over three years as part of the Alzheimer’s Disease Initiative Fund.
[Max Planck Florida Institute] |
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| October 2 – 4, 2023
Boston, Massachusetts, United States |
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| | Roche – Basel, Switzerland |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Van Andel Institute – Grand Rapids, Michigan, United States |
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| | Creative Biolabs – New York, New York, United States |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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