Neural Cell News Volume 17.34 | Aug 30 2023

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    2023-08-30 | NCN 17.34


    Neural Cell News by STEMCELL Technologies
    Vol. 17.34 – 30 August, 2023
    TOP STORY

    Astroglial Exosome HepaCAM Signaling and ApoE Antagonization Coordinates Early Postnatal Cortical Pyramidal Neuronal Axon Growth and Dendritic Spine Formation

    Results defined a secreted astroglial exosome pathway that could spread long-range in vivo and stimulate axon growth of cortical pyramidal neurons.
    [Nature Communications]

    Full Article
    An ISSCR 2022 Innovation Showcase Webinar: How to Choose the Right Neural Cell Culture Model for Your Research Question, presented by Dr. Erin Knock. Click to Watch Now.
    PUBLICATIONSRanked by the impact factor of the journal

    An Engineered Sox17 Induces Somatic to Neural Stem Cell Fate Transitions Independently from Pluripotency Reprogramming

    Scientists reported induced neural stem cell reprogramming from embryonic and aged mouse fibroblasts as well as from human blood using an engineered Sox17.
    [Science Advances]

    Full Article

    ER Stress Induces Caspase-2-tBID-GSDME-Dependent Cell Death in Neurons Lytically Infected with Herpes Simplex Virus Type 2

    Investigators reported that lytic herpes simplex virus type 2 infection of human neuron-like SH-SY5Y cells and primary human and murine brain cells leads to cell death mediated by gasdermin E (GSDME).
    [EMBO Journal]

    Full ArticleGraphical Abstract

    A Novel EGFR Variant EGFRx Maintains Glioblastoma Stem Cells through STAT5

    Researchers found that EGFRx, a novel EGFR variant, played essential roles in the maintenance of the glioblastoma (GBM) stem cell phenotype through constitutive activation of STAT5 and promoted GBM progression.
    [Neuro-Oncology]

    Abstract

    TREM2 Promotes Glioma Progression and Angiogenesis Mediated by Microglia/Brain Macrophages

    Scientists studied whether triggering receptor expressed on myeloid cell 2 (TREM2) influenced glioma progression. They found a gender-dependent effect of glioma growth in wild-type animals injected with GL261-EGFP glioma cells.
    [Glia]

    Full Article

    Active Shrinkage Protects Neurons Following Axonal Transection

    Using in vitro and in vivo neurotrauma model systems based on laser transection and surgical nerve cut, investigators demonstrated that axotomy triggered actomyosin contraction coupled with calpain activity.
    [iScience]

    AbstractGraphical Abstract

    miR-153-3p Suppresses the Differentiation and Proliferation of Neural Stem Cells via Targeting GPR55

    The authors determined the role of miR-153-3p expression in neural stem cell (NSC) differentiation and proliferation. They illustrated that miR-153-3p was decreased and GPR55 was upregulated during NSC differentiation.
    [Aging]

    Full Article

    A Co-Formulation of Interferons alpha2b and Gamma Distinctively Targets Cell Cycle in the Glioblastoma-Derived Cell Line U-87MG

    Researchers designed a microarray experiment aimed at identifying the molecular mechanisms involved in the distinctive effect of HeberFERON compared to the individual interferons in U-87MG model.
    [BMC Cancer]

    Full Article

    Norepinephrine Promotes Neuronal Apoptosis of Hippocampal HT22 Cells by Up-Regulating the Expression of Long Non-Coding RNA MALAT1

    The authors explored the role of norepinephrine in neuronal apoptosis and its association with metastasis-associated lung adenocarcinoma transcript 1 (MALAT1).
    [Stress-The International Journal On The Biology Of Stress]

    Full Article
    Survey results on the needs and challenges in the human pluripotent stem cell field
    REVIEWS

    Microglia-Astrocyte Communication in Alzheimer’s Disease

    Scientists construct current knowledge of microglia-astrocyte communication, highlighting the multifaceted functions of microglia and astrocytes and their role in Alzheimer’s disease.
    [Journal Of Alzheimers Disease]

    Full Article
    INDUSTRY AND POLICY NEWS

    UCI Awarded Grant to Study Sex-Specific Brain Pathway Responses to Stress

    University of California, Irvine (UCI) has been awarded a five-year, $3.5 million grant from the National Institute of Mental Health to study the sex-specific differences in circuits that connect the brain’s stress and reward centers.
    [UCI Health]

    Press Release

    Sanford Receives $2M Grant to Study Brain Abnormalities

    Dr. Abdelhalim Loukil and his lab of researchers at Sanford Research have recently received a $2 million grant from the National Institute of General Medical Sciences.
    [Sanford Health]

    Press Release
    FEATURED EVENT

    Molecular Analysis for Precision Oncology Congress 2023

    October 4 – 6, 2023
    Paris, France

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Tumor Immunology

    National Cancer Institute – Bethesda, Maryland, United States

    Postdoctoral Research Fellow – iPSC Models of Parkinson’s Disease

    Royal Infirmary – Edinburgh, Scotland, United Kingdom

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    PhD Internship – Neuroscience

    Roche – Basel, Switzerland

    Postdoctoral Associate – Cellular Heterogeneity and Circuit Organization of Brains

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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