 | | Vol. 17.35 – 6 September, 2023 |
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| Scientists identified Kunitz-type protease inhibitor TFPI2 as a critical factor connecting these cell populations and their associated glioblastoma hallmarks of stemness and immunosuppression.
[Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers observed astrocytes and microglia from human brains contained greater amounts of synaptic protein in Alzheimer’s disease compared with non-disease controls, and that proximity to amyloid-β plaques and the APOE4 risk gene exacerbated this effect.
[Cell Reports Medicine] |
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| Using isogenic pairs of induced pluripotent stem cells (iPSCs) harboring different familial ALS mutations, the authors assessed the capacity of iPSC-derived lower motor neurons, sensory neurons, astrocytes, and superficial cortical neurons to capture disease features.
[Cell Reports] |
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| Investigators showed that BCL2 like 13 (BCL2L13) expression was significantly upregulated in glioblastoma multiforme (GBM) cell lines and clinical GBM tissue samples.
[Cell Death & Disease] |
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| The authors showed that inducible GD3 deletion in postnatal radial glia-like neural stem cell (NSC) promotes NSC activation, resulting in the loss of the long-term maintenance of the adult NSC pools.
[Glia] |
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| Scientists demonstrated that osimertinib induced paraptosis in glioblastoma cells, as evidenced by the formation of cytoplasmic vacuoles, accumulation of ubiquitinated proteins, and upregulation of endoplasmic reticulum stress markers like CHOP.
[Cell Death Discovery] |
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| Researchers determined whether coiled‑coil‑helix‑coiled‑coil‑helix domain‑containing protein 2 (CHCHD2) played a functional role in U87 glioblastoma cells expressing the constitutively active epidermal growth factor receptor variant III.
[International Journal of Oncology] |
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| Investigators provided evidence implicating midbrain dopamine neurons in the innervation of oligodendrocyte lineage cells in the anterior corpus callosum and nearby white matter tracts of male and female adult mice.
[Brain Structure & Function] |
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| The authors investigated the potential of recombinant human FGF21 in inhibiting ferroptosis of nerve cells and improving limb function after spinal cord injury, along with its underlying mechanisms.
[Brain Research Bulletin] |
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| Scientists review the mechanisms of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) expression and activation and discussed the role of active NLRP3 inflammasome in the pathogenesis of neurodegenerative diseases, particularly focusing on Alzheimer’s disease.
[Molecular Psychiatry] |
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Investigators provide an overview of the intercellular division of metabolic labor that occurs in both the normal brain and the glioblastoma (GBM) tumor microenvironment and then discuss the implications of these interactions for GBM therapy.
[Genes & Development] |
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| Dr. Jae K. Lee was awarded a $6 million grant from the National Institute of Neurological Disorders and Stroke (NINDS) for his RM1 Interdisciplinary Team Science Grant to advance cellular therapies for spinal cord injuries.
[University of Miami] |
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| October 1 – 4, 2023
Whistler, British Columbia, Canada |
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| | University of Illinois at Urbana-Champaign – Champaign, Illinois, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Boston University – Boston, Massachusetts, United States |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | Royal Infirmary – Edinburgh, Scotland, United Kingdom |
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