 | | Vol. 17.36 – 13 September, 2023 |
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| Scientists generated a transgenic mouse line that expressed membrane-anchored GCaMP6s in oligodendrocyte precursor cells (OPCs) and used longitudinal two-photon microscopy to monitor OPC calcium dynamics in the cerebral cortex.
[Nature Neuroscience] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors used single cell RNA-sequencing/single nucleus RNA-sequencing to analyze over 298,000 cells and nuclei during macroglia differentiation from mouse embryonic and human-induced pluripotent stem cells.
[Nature Neuroscience] |
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| Researchers uncovered the role of FOXA2 in human serotonin neuron (SN) development and improved the differentiation efficiency of human pluripotent stem cells into SNs by repressing FOXA2 expression.
[Advanced Science] |
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| Investigators quantified the levels of lactic acid in senescent microglia, and hippocampus tissues of naturally aged mice and Alzheimer’s disease mice models.
[Journal of Neuroinflammation] |
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| The effects of human umbilical cord-MSC-derived exosomes on inflammatory cytokine expression, oxidative stress, and microglia polarization were studied by immunofluorescence and western blotting.
[CNS Neuroscience & Therapeutics] |
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| Scientists determined if exogenous Klotho, when added to neuronal and astrocytic cell cultures, could reduce the phosphorylation levels of certain insulin signaling effectors and enhance antioxidant strategies in these cells.
[Scientific Reports] |
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| Downregulation of miRNA-186 in response to a specific miRNA inhibitor resulted in upregulation of Bmi-1 and FoxG1, while maintaining neural stem cells self-renewal.
[Human Cell] |
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| To study the effect of cordycepin combined with temozolomide on glioblastoma, investigators explored the effect of the combination based on network pharmacology and biological verification.
[Journal of Cancer Research and Clinical Oncology] |
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| Atomic force microscopy was utilized to compare the roughness and height of the cell surfaces of U87 MG glioblastoma cells and astrocytes to reveal the general morphological characteristics of these cells.
[Histochemistry and Cell Biology] |
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| The authors summarize available data on the role of autophagy in neuroglia – a crucial participant of Alzheimer’s disease (AD) pathology. They present known information on the relation between autophagy and AD in the context of given glia type.
[Molecular Psychiatry] |
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| Investigators discuss current and future strategies being developed to optimize chimeric antigen receptor (CAR) T cells for efficacy in patients with glioblastoma.
[Molecular Diagnosis & Therapy] |
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| Spinogenix, Inc. announced a second grant award by the National Institute of Health (NIH). The new $3 million grant titled “Development of a Novel, Regenerative Therapy to Reverse Synapse Loss in Alzheimer’s Disease” will continue to support the development of SPG302.
[Spinogenix, Inc.] |
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| Many publishers, including Elsevier and Springer Nature, have said that authors can use ChatGPT and other large language model (LLM) tools to help them produce their manuscripts, as long as they declare it.
[Nature News] |
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| October 16 – 19, 2023
Hong Kong |
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| | Northwestern University – Chicago, Illinois, United States |
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| | Boston University – Boston, Massachusetts, United States |
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| | University of Illinois at Urbana-Champaign – Champaign, Illinois, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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