 | | Vol. 17.37 – 20 September, 2023 |
| |
|
|
| Researchers introduced chitosan scaffolds as an alternative culture platform to costly animal-sourced feeders, Matrigel, and Geltrex for human neural stem cell expansion.
[Matter] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Using patient-derived dopaminergic neurons, investigators found that phosphorylation of parkin by Ca2+/calmodulin-dependent protein kinase 2 at Ser9 led to activation of parkin in a neuronal-activity-dependent manner.
[Neuron] |
|
|
|
| Scientists systematically identified over 11,039 circRNAs expressed in vulnerable dopamine and pyramidal neurons laser-captured from 190 human brains and non-neuronal cells using ultra-deep, total RNA sequencing.
[Nature Communications] |
|
|
|
| Researchers showed that microglia could import lactate, and this was coupled with increased lysosomal acidification. In vitro, loss of the monocarboxylate transporter MCT4 in microglia prevented lactate-induced lysosomal modulation and led to defective cargo degradation.
[Nature Communications] |
|
|
|
| The authors developed genetic tools to label endogenous sodium channels and their scaffolding protein, to reveal their nanoscale organization and longitudinally image axon initial segment plasticity in hippocampal neurons in slices and primary cultures.
[Science Advances] |
|
|
|
| To model the mechanism of tau propagation and synaptic toxicity of distinct tau conformers, scientists inoculated wild-type primary mouse neurons with structurally characterized Sarkosyl-insoluble tau isolates from the frontal cortex of six Alzheimer’s disease cases and monitored the impact for 14 days.
[Cell & Bioscience] |
|
|
|
| Rat model of spinal cord injury was established and subsequently evaluated for motor function, pathological conditions, and apoptosis of spinal cord neurons.
[CNS Neuroscience & Therapeutics] |
|
|
|
| Investigators induced drug resistance in primary glioblastoma cell lines by treatment with an enhancer of zeste homolog 2 (EZH2) inhibitor and observed increases in the expression of stemness markers associated with glioblastoma stem cells in the drug-resistant cells.
[Cancer Gene Therapy] |
|
|
|
| 1-methyl-4-phenylpyridinium and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s disease models were established in this study. Behavioral tests, cell cytotoxicity assay, tyrosine hydroxylase, and Nissl staining were performed to evaluate the antiparkinsonian effect of buddlejasaponin IVb.
[Journal of Ethnopharmacology] |
|
|
|
| The authors analyzed the functions of NCAM2 in the regulation of radial glial progenitors in adult neurogenesis and during corticogenesis and characterized the presence of NCAM2 across the main cell types of the neurogenic process in the dentate gyrus.
[Cerebral Cortex] |
|
|
|
| Zebrafish were utilized as an experimental model and subdivided into control, Indomethacin (INDO) 1 mg/Kg, INDO 2 mg/Kg, INDO 3 g/Kg, α-TP 2 mg/Kg, α-TP 2 mg/Kg + INDO 1 mg/Kg and α-TP + INDO 2 mg/Kg groups.
[Naunyn-Schmiedebergs Archives Of Pharmacology] |
|  |
|
|
|
| The authors summarize the current knowledge on the contribution of the inflammasomes in glioma and therapeutic insights.
[Cell Communication and Signaling] |
|
|
|
| Scientists elaborate mammalian target of rapamycin (mTOR) signaling network mainly in the brain, point to gaps of knowledge, and define how and in which ways mTOR signaling can be connected with Alzheimer’s disease pathogenesis and symptoms.
[CNS Neuroscience & Therapeutics] |
|
|
|
| Investigators include preclinical studies examining the efficacy of minocycline in preclinical traumatic brain injury (TBI) models as well as recommendations for a clinical trial to test minocycline to treat TBI.
[Neurotherapeutics] |
|
|
|
|
| The Breakthrough Prize Foundation has announced Andrew B. Singleton, Ph.D., a distinguished investigator at NIH as one of three recipients of the 2024 Breakthrough Prize in Life Sciences.
[National Insitute on Aging] |
|
|
|
|
| October 18 – 21, 2023
EMBL Heidelberg and Virtual |
|
|
|
|
|
| | University of Michigan-Ann Arbor – Ann Arbor, Michigan, United States |
|
|
|
| | Beth Israel Deaconess Medical Center & Harvard Medical School – Boston, Massachusetts, United States |
|
|
|
| | University of Houston – Houston, Texas, United States |
|
|
|
| | Rutgers University – New Brunswick, New Jersey, United States |
|
|
|
| | Northwestern University – Chicago, Illinois, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
