Neural Cell News Volume 17.38 | Sep 27 2023

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    Noshin Noorjahan
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    2023-09-27 | NCN 17.38


    Neural Cell News by STEMCELL Technologies
    Vol. 17.38 – 27 September, 2023
    TOP STORY

    APOE4 Impairs the Microglial Response in Alzheimer’s Disease by Inducing TGFβ-Mediated Checkpoints

    Researchers showed in mice and humans a negative role of microglial APOE4 in the induction of the neurodegenerative microglia response to neurodegeneration.
    [Nature Immunology]

    Abstract
    STEMCELL's Neural Crest Differentiation Kit enables high-purity generation of neural crest precursors from human pluripotent stem cells.
    PUBLICATIONSRanked by the impact factor of the journal

    IL-12 Sensing in Neurons Induces Neuroprotective CNS Tissue Adaptation and Attenuates Neuroinflammation in Mice

    Scientists mapped Interleukin-12 (IL-12) receptor expression to natural killer and T cells as well as neurons and oligodendrocytes.
    [Nature Neuroscience]

    Full Article

    Circadian Clock Disruption Promotes the Degeneration of Dopaminergic Neurons in Male Drosophila

    Investigators demonstrated that circadian clocks regulated the rhythmicity and magnitude of the vulnerability of dopaminergic neurons to oxidative stress in male Drosophila.
    [Nature Communications]

    Full Article

    Crosstalk between PARN and EGFR-STAT3 Signaling Facilitates Self-Renewal and Proliferation of Glioblastoma Stem Cells

    Researchers identified that poly(A)-specific ribonuclease (PARN), a key modulator of RNA metabolism, activated EGFR-STAT3 signaling to support glioblastoma stem cells.
    [Cancer Research]

    Abstract

    Pattern Detection in the TGFβ Cascade Controls the Induction of Long-Term Synaptic Plasticity

    The authors showed that transforming growth factor β (TGFβ) acted as a “repetition detector” during the induction of two-trial long-term memory.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Peptidergic Modulation of Motor Neuron Output via CART Signaling at C Bouton Synapses

    Scientists identified roles for a neuropeptide, cocaine- and amphetamine-regulated transcript (CART), in the control of movement vigor.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    Identification of a miRNA Multi-Targeting Therapeutic Strategy in Glioblastoma

    Using an integrative and comprehensive analysis of the TCGA database and the transcriptome of glioblastoma (GBM) biopsies, the authors identified three critical and clinically relevant miRNAs for GBM, miR-17-3p, miR-222, and miR-340.
    [Cell Death & Disease]

    Full Article

    Microglia-Dependent Neuroprotective Effects of 4-Octyl Itaconate Against Rotenone– and MPP+–Induced Neurotoxicity in Parkinson’s Disease

    Researchers investigated the neuroprotective potential of 4-octyl itaconate, a cell-permeable derivative of itaconate, in cellular models of Parkinson’s disease.
    [Scientific Reports]

    Full Article

    Stem Cells-Derived Exosomes Alleviate Neurodegeneration and Alzheimer’s Pathogenesis by Ameliorating Neuroinflamation, and Regulating the Associated Molecular Pathways

    Investigators examined how NSC-exos could protect human neuroblastoma cells SH-SY5Y. NSC-exos were derived from human NSCs by ultracentrifugation and the therapeutic effects of the NSC-exos were then investigated in vitro.
    [Scientific Reports]

    Full Article

    Downregulation of NHE1 Expression Attenuates Apoptosis of Primary Hippocampal Neurons of an Epilepsy Model through the Calpain-1 Pathway

    Primary hippocampal neurons were cultured in an Mg2+-free medium to establish an epilepsy cell model. Designed shNHE1 lentivirus was used to silence Na(+)/H(+) exchanger isoform 1 (NHE1) level in primary neurons.
    [Neuroscience Letters]

    Abstract

    PLEKHA4 Promotes Glioblastoma Progression through Apoptosis Inhibition, Tumor Cell Migration, and Macrophage Infiltration

    Scientists analyzed PLEKHA4 expression in tumor tissues using the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases. Additionally, they utilized TCGA data to investigate its impact on prognosis, pathway enrichment, and immune infiltration.
    [Immunobiology]

    Abstract
    Scientific resources to support your organoids research. Learn More!
    REVIEWS

    RIP3 in Necroptosis: Underlying Contributions to Traumatic Brain Injury

    The authors review different domains of receptor-interacting protein kinase (RIP) 3, multiple analyses of necroptosis, and associations between necroptosis and traumatic brain injury, RIP3, RIP1, and mixed lineage kinase domain-like.
    [Neurochemical Research]

    Abstract
    INDUSTRY AND POLICY NEWS

    Brain Canada’s Flagship Program Awards $2.8 Million for Brain Research

    The Future Leaders in Canadian Brain Research program aims to accelerate novel and transformative research that will fundamentally change our understanding of nervous system function and dysfunction and their impact on health.
    [Brain Canada Foundation (Globe Newswire)]

    Press Release

    BrainStorm’s Case for ALS Approval Relies on ‘Grossly Deficient’ Data, FDA Finds

    The US FDA said that it has deep reservations about NurOwn, an investigational ALS treatment from BrainStorm Cell Therapeutics.
    [STAT News]

    Press Release
    FEATURED EVENT

    AACR Special Conference: Brain Cancer

    October 19 – 22, 2023
    Minneapolis, Minnesota, United States

    > See All Events

    JOB OPPORTUNITIES

    PhD Position – Molecular and Computational Neurogenomics

    VIB – Antwerp, Belgium

    Postdoctoral Associate – NMR-based Metabolomics and Metabolomic Imaging

    Massachusetts General Hospital – Boston, Massachusetts, United States

    Postdoctoral Position – Next Generation Organoid

    Helmholtz Association of German Research Centres – Berlin, Germany

    Postdoctoral Researchers – Bioengineering and Morphogenesis

    KU Leuven – Leuven, Belgium

    Tenure Track Faculty Position – Bioinnovations in Brain Cancer

    University of Michigan-Ann Arbor – Ann Arbor, Michigan, United States

    > See All Jobs

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