 | | Vol. 17.39 – 4 October, 2023 |
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| Scientists generated a single-cell transcriptomic atlas of the aged human prefrontal cortex covering 2.3 million cells from postmortem human brain samples of 427 individuals with varying degrees of Alzheimer’s disease pathology and cognitive impairment.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using intracranial injections in mice and assembloids between small-cell lung cancer (SCLC) aggregates and human cortical organoids in culture, the authors found that SCLC cells recruited reactive astrocytes to the tumor microenvironment.
[Nature Cell Biology] |
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| Upon examining chitinase-3–like protein 1 (CHI3L1)’s biological function in neuroinflammation, researchers found that CHI3L1 expression correlated with cognitive impairment in a neuromyelitis optica patient cohort.
[Science Advances] |
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| Infant medulloblastoma-bearing Math1-cre::Ptch1 Fl/Fl mice were treated with intraventricular Vismodegib in order to evaluate efficacy on tumor growth and systemic side effects.
[Neuro-Oncology] |
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| Investigators developed a screening platform, ATRIVIEW®, for molecules that activate neuronal differentiation of adult mouse NSCs.
[Experimental & Molecular Medicine] |
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| The authors investigated the mechanism of protein phosphatase Mg2+/Mn2+ dependent 1 K (PPM1K) mediated metabolic disorder of branched-chain amino acids by promoting fatty acid oxidation led to ferroptosis after cerebral ischemia-reperfusion injury.
[Cell Death & Disease] |
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| Investigators used patient-derived, typically resistant, glioma stem-like cells in combination with the previously validated preclinical Inovitro™ TTFields system together with a number of therapeutic DNA damage response inhibitors.
[British Journal of Cancer] |
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| Scientists evaluated the anti-tumor effect of Vγ9Vδ2 T cells in 26 glioma cases through the patient-derived tumor cell clusters model.
[Journal of Translational Medicine] |
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| Researchers investigated the role of myosin heavy chain 9 (MYH9) in glioma and determined whether MYH9 was involved in the temozolomide chemoresistance of glioma cells.
[Cancer Cell International] |
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| The authors review the structures of brain-derived amyloid filaments that have been determined so far and discuss their impact on research into neurodegeneration.
[Nature] |
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| PharmaTher Holdings Ltd. announced the US FDA has accepted the abbreviated new drug application for KETARX™ to the FDA.
[PharmaTher Holdings Ltd.] |
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| October 20 – 24, 2023
Madrid, Spain |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Massachusetts General Hospital – Boston, Massachusetts, United States |
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| | Helmholtz Association of German Research Centres – Berlin, Germany |
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| | KU Leuven – Leuven, Belgium |
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